Publications by authors named "April Case"

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Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor.
Gordon J Lockbaum, Maureen M Lynes, Sophie A Shen, Julie Liu, Nicholas Holt, April Case

Commun Biol· April 2025

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A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair.
Jennifer Castro, Matthew H Daniels, David Brennan, Brian Johnston, Deepali Gotur, April Case

Cancer Res· February 2025

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Development of assays to support identification and characterization of modulators of DExH-box helicase DHX9.
Deepali Gotur, April Case, Julie Liu, E Allen Sickmier, Nicholas Holt

SLAS Discov· December 2023

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A Mass Spectrometric Assay of METTL3/METTL14 Methyltransferase Activity.
Shane M Buker, Zachary A Gurard-Levin, Benjamin D Wheeler, Michael D Scholle, April W Case

SLAS Discov· April 2020

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Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.
Han Dai, April W Case, Thomas V Riera, Thomas Considine, Jessica E Lee

Nat Commun· July 2015

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Evidence for a common mechanism of SIRT1 regulation by allosteric activators.
Basil P Hubbard, Ana P Gomes, Han Dai, Jun Li, April W Case

Science· March 2013

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SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator.
Han Dai, Lauren Kustigian, David Carney, April Case, Thomas Considine

J Biol Chem· October 2010

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Effect of Peptide-Chelate Architecture on Metabolic Stability of Peptide-based MRI Contrast Agents.
Zhaoda Zhang, Andrew F Kolodziej, Jianfeng Qi, Shrikumar A Nair, Xifang Wang, April W Case

New J Chem· February 2010

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Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors.
Lixin Qiao, Sungwoon Choi, April Case, Thomas G Gainer, Kathleen Seyb

Bioorg Med Chem Lett· November 2009

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Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors.
Ara H Mermerian, April Case, Ross L Stein, Gregory D Cuny

Bioorg Med Chem Lett· July 2007

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Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic slow-binding inhibitor.
April Case, Ross L Stein

Biochemistry· January 2007

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Mechanistic studies of ubiquitin C-terminal hydrolase L1.
April Case, Ross L Stein

Biochemistry· February 2006

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Structure-activity relationship study of novel tissue transglutaminase inhibitors.
Eric Duval, April Case, Ross L Stein, Gregory D Cuny

Bioorg Med Chem Lett· April 2005

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Development of a mechanism-based assay for tissue transglutaminase--results of a high-throughput screen and discovery of inhibitors.
April Case, Jake Ni, Li-An Yeh, Ross L Stein

Anal Biochem· March 2005

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Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.
Yichin Liu, Hilal A Lashuel, Sungwoon Choi, Xuechao Xing, April Case

Chem Biol· September 2003

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Kinetic analysis of the action of tissue transglutaminase on peptide and protein substrates.
April Case, Ross L Stein

Biochemistry· August 2003

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Enzymatic reaction of silent substrates: kinetic theory and application to the serine protease chymotrypsin.
April Case, W Phillip Huskey, Ross L Stein

Biochemistry· April 2003

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Mechanistic origins of the substrate selectivity of serine proteases.
April Case, Ross L Stein

Biochemistry· March 2003

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