Publications by authors named "Arvinder Dhalla"

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An oral robotic pill reliably and safely delivers teriparatide with high bioavailability in healthy volunteers: A phase 1 study.
Joshua T Myers, Alyson Yamaguchi, April Toledo Vo, Anvesh Dasari, Archana Battiwala, Arvinder K Dhalla

Br J Clin Pharmacol· August 2025

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Preference for a Novel Oral Alternative to Parenterally Administered Medications.
Joshua T Myers, Jacques Van Dam, Mir Imran, Mir Hashim, Arvinder K Dhalla

Patient Prefer Adherence· July 2024

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A robotic pill for oral delivery of biotherapeutics: safety, tolerability, and performance in healthy subjects.
Arvinder K Dhalla, Ziad Al-Shamsie, Simret Beraki, Anvesh Dasari, Leonard C Fung

Drug Deliv Transl Res· January 2022

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Electrophysiological effects of ranolazine in a goat model of lone atrial fibrillation.
Dragan Opačić, Arne van Hunnik, Stef Zeemering, Arvinder Dhalla, Luiz Belardinelli

Heart Rhythm· April 2021

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Jejunal wall delivery of insulin via an ingestible capsule in anesthetized swine-A pharmacokinetic and pharmacodynamic study.
Mir Hashim, Radhika Korupolu, Baber Syed, Kyle Horlen, Simret Beraki, Arvinder K Dhalla

Pharmacol Res Perspect· October 2019

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Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late Ii), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties.
Jeff A Zablocki, Elfatih Elzein, Xiaofen Li, Dmitry O Koltun, Eric Q Parkhill, Arvinder K Dhalla

J Med Chem· October 2016

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Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with improved efficacy and potency relative to ranolazine.
Dmitry O Koltun, Eric Q Parkhill, Elfatih Elzein, Tetsuya Kobayashi, Robert H Jiang, Arvinder K Dhalla

Bioorg Med Chem Lett· July 2016

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Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late INai) of the cardiac NaV 1.5 channel with improved efficacy and potency relative to ranolazine.
Dmitry O Koltun, Eric Q Parkhill, Elfatih Elzein, Tetsuya Kobayashi, Gregory T Notte, Arvinder K Dhalla

Bioorg Med Chem Lett· July 2016

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Inhibition of late Na+ current, a novel target to improve diastolic function and electrical abnormalities in Dahl salt-sensitive rats.
Liguo Chi, Luiz Belardinelli, Aliya Zeng, Ryoko Hirakawa, Sridharan Rajamani, Arvinder K Dhalla

Am J Physiol Heart Circ Physiol· May 2016

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Effect of Ranolazine Monotherapy on Glycemic Control in Subjects With Type 2 Diabetes.
Robert H Eckel, Robert R Henry, Patrick Yue, Arvinder Dhalla, Pamela Wong

Diabetes Care· July 2015

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Ranolazine reduces remodeling of the right ventricle and provoked arrhythmias in rats with pulmonary hypertension.
John T Liles, Kirsten Hoyer, Jason Oliver, Liguo Chi, Arvinder K Dhalla

J Pharmacol Exp Ther· June 2015

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Blockade of Na+ channels in pancreatic α-cells has antidiabetic effects.
Arvinder K Dhalla, Ming Yang, Yun Ning, Kristopher M Kahlig, Michael Krause

Diabetes· October 2014

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The beneficial effects of ranolazine on cardiac function after myocardial infarction are greater in diabetic than in nondiabetic rats.
Iordanis Mourouzis, Polixeni Mantzouratou, Georgios Galanopoulos, Erietta Kostakou, Arvinder K Dhalla

J Cardiovasc Pharmacol Ther· September 2014

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Selective inhibition of the late sodium current has no adverse effect on electrophysiological or contractile function of the normal heart.
Sarah Fernandes, Kirsten Hoyer, Gongxin Liu, Wei-Qun Wang, Arvinder K Dhalla

J Cardiovasc Pharmacol· June 2014

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Reduction of free fatty acids, safety, and pharmacokinetics of oral GS-9667, an A(1) adenosine receptor partial agonist.
Peter M Staehr, Arvinder K Dhalla, Julia Zack, Xuegong Wang, Yu L Ho

J Clin Pharmacol· April 2013

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A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias.
Luiz Belardinelli, Gongxin Liu, Cathy Smith-Maxwell, Wei-Qun Wang, Nesrine El-Bizri, Arvinder K Dhalla

J Pharmacol Exp Ther· January 2013

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Adenosine A₁ receptors do not play a major role in the regulation of lipogenic gene expression in hepatocytes.
Ming Yang, Ruth Chu, Jeffrey W Chisholm, Holger Doege, Luiz Belardinelli, Arvinder K Dhalla

Eur J Pharmacol· May 2012

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Ranolazine increases β-cell survival and improves glucose homeostasis in low-dose streptozotocin-induced diabetes in mice.
Yun Ning, Wei Zhen, Zhuo Fu, Jenny Jiang, Dongmin Liu, Arvinder K Dhalla

J Pharmacol Exp Ther· April 2011

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Effect of ranolazine on A1C and glucose levels in hyperglycemic patients with non-ST elevation acute coronary syndrome.
Jeffrey W Chisholm, Allison B Goldfine, Arvinder K Dhalla, Eugene Braunwald, David A Morrow

Diabetes Care· June 2010

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Ranolazine, an antianginal agent, markedly reduces ventricular arrhythmias induced by ischemia and ischemia-reperfusion.
Arvinder K Dhalla, Wei-Qun Wang, Joan Dow, John C Shryock, Luiz Belardinelli

Am J Physiol Heart Circ Physiol· November 2009

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Abnormal left ventricular relaxation in patients with long QT syndrome.
Luiz Belardinelli, Arvinder Dhalla, John Shryock

Eur Heart J· November 2009

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A1 adenosine receptor: role in diabetes and obesity.
Arvinder K Dhalla, Jeffrey W Chisholm, Gerald M Reaven, Luiz Belardinelli

Handb Exp Pharmacol· September 2009

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Ranolazine as a cardioplegia additive improves recovery of diastolic function in isolated rat hearts.
Hyosook Hwang, Joseph M Arcidi, Sharon L Hale, Boris Z Simkhovich, Luiz Belardinelli, Arvinder K Dhalla

Circulation· September 2009

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Ranolazine as an adjunct to cardioplegia: a potential new therapeutic application.
Hyosook Hwang, Joseph M Arcidi, Sharon L Hale, Boris Z Simkhovich, Luiz Belardinelli, Arvinder K Dhalla

J Cardiovasc Pharmacol Ther· June 2009

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Partial A1 adenosine receptor agonist regulates cardiac substrate utilization in insulin-resistant rats in vivo.
Jane Shearer, David L Severson, Lin Su, Luiz Belardinelli, Arvinder K Dhalla

J Pharmacol Exp Ther· January 2009

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