Publications by authors named "Benjamin Fauber"

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Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase.
BinQing Wei, Kirk Robarge, Sharada S Labadie, Jinhua Chen, Laura B Corson, Benjamin P Fauber

Bioorg Med Chem Lett· March 2022

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Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice.
Hans E Purkey, Kirk Robarge, Jinhua Chen, Zhongguo Chen, Laura B Corson, Benjamin P Fauber

ACS Med Chem Lett· October 2016

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Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties.
Olivier René, Benjamin P Fauber, Adrian Barnard, Kerry Chapman, Yuzhong Deng

Bioorg Med Chem Lett· September 2016

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Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists.
Benjamin P Fauber, Alberto Gobbi, Pascal Savy, Brenda Burton, Yuzhong Deng

Bioorg Med Chem Lett· October 2015

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Palladium-Catalyzed Ring Expansion of Spirocyclopropanes to Form Caprolactams and Azepanes.
Olivier René, Iain A Stepek, Alberto Gobbi, Benjamin P Fauber, Simon Gaines

J Org Chem· October 2015

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Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists.
Benjamin P Fauber, Alberto Gobbi, Kirk Robarge, Aihe Zhou, Adrian Barnard

Bioorg Med Chem Lett· August 2015

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Discovery of 1-{4-[3-fluoro-4-((3s,6r)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C (RORc or RORγ) inverse agonist.
Benjamin P Fauber, Olivier René, Yuzhong Deng, Jason DeVoss, Céline Eidenschenk

J Med Chem· July 2015

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Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action.
Olivier René, Benjamin P Fauber, Gladys de Leon Boenig, Brenda Burton, Céline Eidenschenk

ACS Med Chem Lett· March 2015

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Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
Sascha Rutz, Nobuhiko Kayagaki, Qui T Phung, Celine Eidenschenk, Rajkumar Noubade, Benjamin P Fauber

Nature· February 2015

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Experimental and Computational Studies of the Diastereoselective Alkylations of 3-Substituted γ-Sultams.
Benjamin P Fauber, Kyle Clagg, Paul Gibbons, Olivier René

J Org Chem· January 2015

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Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.
Sharada Labadie, Peter S Dragovich, Jinhua Chen, Benjamin P Fauber, Jason Boggs

Bioorg Med Chem Lett· January 2015

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A reversed sulfonamide series of selective RORc inverse agonists.
Monique B van Niel, Benjamin P Fauber, Matthew Cartwright, Simon Gaines, Jonathan C Killen

Bioorg Med Chem Lett· December 2014

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Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase.
Benjamin P Fauber, Peter S Dragovich, Jinhua Chen, Laura B Corson, Charles Z Ding

Bioorg Med Chem Lett· December 2014

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Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonists.
Benjamin P Fauber, Olivier René, Gladys de Leon Boenig, Brenda Burton, Yuzhong Deng

Bioorg Med Chem Lett· August 2014

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Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.
Peter S Dragovich, Benjamin P Fauber, Jason Boggs, Jinhua Chen, Laura B Corson

Bioorg Med Chem Lett· August 2014

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Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-γ (RORγ or RORc).
Benjamin P Fauber, Steven Magnuson

J Med Chem· July 2014

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Palladium-catalyzed α-arylation of sultams with aryl and heteroaryl iodides.
Olivier René, Benjamin P Fauber, Sushant Malhotra, Herbert Yajima

Org Lett· July 2014

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Identification of tertiary sulfonamides as RORc inverse agonists.
Benjamin P Fauber, Olivier René, Brenda Burton, Christine Everett, Alberto Gobbi

Bioorg Med Chem Lett· May 2014

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Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc.
Benjamin P Fauber, Gladys de Leon Boenig, Brenda Burton, Céline Eidenschenk, Christine Everett

Bioorg Med Chem Lett· December 2013

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Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase.
Benjamin P Fauber, Peter S Dragovich, Jinhua Chen, Laura B Corson, Charles Z Ding

Bioorg Med Chem Lett· October 2013

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Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase.
Peter S Dragovich, Benjamin P Fauber, Laura B Corson, Charles Z Ding, Charles Eigenbrot

Bioorg Med Chem Lett· June 2013

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Discovery and optimization of a novel series of potent mutant B-Raf(V600E) selective kinase inhibitors.
Melissa M Vasbinder, Brian Aquila, Martin Augustin, Huawei Chen, Tony Cheung, Benjamin P Fauber

J Med Chem· March 2013

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Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO.
Bin Yang, Alexander W Hird, Daniel John Russell, Benjamin P Fauber, Les A Dakin

Bioorg Med Chem Lett· July 2012

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Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.
Till Maurer, Lindsay S Garrenton, Angela Oh, Keith Pitts, Daniel J Anderson, Benjamin P Fauber

Proc Natl Acad Sci U S A· April 2012

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Concise syntheses of (-)-galanthamine and (+/-)-codeine via intramolecular alkylation of a phenol derivative.
Philip Magnus, Neeraj Sane, Benjamin P Fauber, Vince Lynch

J Am Chem Soc· November 2009

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