Publications by authors named "Benoit Gigant"

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Microtubule nucleation: How the NEDD1:MZT1:GCP3 trio captures the γ-TuRC.
Clémence Paumier, Cécile Sauvanet, Benoît Gigant

J Cell Biol· August 2025

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Centriolar cap proteins CP110 and CPAP control slow elongation of microtubule plus ends.
Saishree S Iyer, Fangrui Chen, Funso E Ogunmolu, Shoeib Moradi, Vladimir A Volkov, Benoît Gigant

J Cell Biol· March 2025

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The structure of a Tau fragment bound to tubulin prompts new hypotheses on Tau mechanism and oligomerization.
Liza Ammar Khodja, Valérie Campanacci, Guy Lippens, Benoît Gigant

PNAS Nexus· November 2024

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The C-terminus of stathmin-like proteins governs the stability of their complexes with tubulin.
Valérie Campanacci, Benoît Gigant

Biochem Biophys Res Commun· November 2023

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Engineering of brick and staple components for ordered assembly of synthetic repeat proteins.
Jessalyn Miller, Agathe Urvoas, Benoit Gigant, Malika Ouldali, Ana Arteni

J Struct Biol· September 2023

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Structural convergence for tubulin binding of CPAP and vinca domain microtubule inhibitors.
Valérie Campanacci, Agathe Urvoas, Liza Ammar Khodja, Magali Aumont-Nicaise, Magali Noiray, Benoît Gigant

Proc Natl Acad Sci U S A· May 2022

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B-nor-methylene Colchicinoid PT-100 Selectively Induces Apoptosis in Multidrug-Resistant Human Cancer Cells via an Intrinsic Pathway in a Caspase-Independent Manner.
Andreas Stein, Persefoni Hilken Née Thomopoulou, Corazon Frias, Sina M Hopff, Paloma Varela, Benoît Gigant

ACS Omega· January 2022

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GTP-dependent formation of straight tubulin oligomers leads to microtubule nucleation.
Rie Ayukawa, Seigo Iwata, Hiroshi Imai, Shinji Kamimura, Masahito Hayashi, Benoît Gigant

J Cell Biol· April 2021

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Structural snapshots of the kinesin-2 OSM-3 along its nucleotide cycle: implications for the ATP hydrolysis mechanism.
Paloma F Varela, Mélanie Chenon, Christophe Velours, Kristen J Verhey, Julie Ménétrey, Benoît Gigant

FEBS Open Bio· March 2021

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Discovery of dihydrofuranoallocolchicinoids - Highly potent antimitotic agents with low acute toxicity.
Ekaterina S Shchegravina, Elena V Svirshchevskaya, Sebastien Combes, Diane Allegro, Pascale Barbier, Benoit Gigant

Eur J Med Chem· December 2020

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The Mechanism of Tubulin Assembly into Microtubules: Insights from Structural Studies.
Marcel Knossow, Valérie Campanacci, Liza Ammar Khodja, Benoît Gigant

iScience· September 2020

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Elucidating Tau function and dysfunction in the era of cryo-EM.
Guy Lippens, Benoît Gigant

J Biol Chem· June 2019

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Insight into microtubule nucleation from tubulin-capping proteins.
Valérie Campanacci, Agathe Urvoas, Soraya Cantos-Fernandes, Magali Aumont-Nicaise, Ana-Andreea Arteni, Benoît Gigant

Proc Natl Acad Sci U S A· May 2019

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Selection and Characterization of Artificial Proteins Targeting the Tubulin α Subunit.
Valérie Campanacci, Agathe Urvoas, Tanja Consolati, Soraya Cantos-Fernandes, Magali Aumont-Nicaise, Benoît Gigant

Structure· March 2019

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1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation.
Timothée Naret, Ilhem Khelifi, Olivier Provot, Jérôme Bignon, Hélène Levaique, Benoît Gigant

J Med Chem· February 2019

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Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin.
Weiyi Wang, Soraya Cantos-Fernandes, Yuncong Lv, Hureshitanmu Kuerban, Shoeb Ahmad, Benoît Gigant

Nat Commun· July 2017

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Mechanism of microtubule stabilization by taccalonolide AJ.
Yuxi Wang, Yamei Yu, Guo-Bo Li, Shu-Ang Li, Chengyong Wu, Benoît Gigant

Nat Commun· June 2017

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The structural switch of nucleotide-free kinesin.
Luyan Cao, Soraya Cantos-Fernandes, Benoît Gigant

Sci Rep· February 2017

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Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin.
Shoeb Ahmad, Ludovic Pecqueur, Birgit Dreier, Djemel Hamdane, Magali Aumont-Nicaise, Benoît Gigant

Sci Rep· July 2016

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NMR Meets Tau: Insights into Its Function and Pathology.
Guy Lippens, Isabelle Landrieu, Caroline Smet, Isabelle Huvent, Neha S Gandhi, Benoît Gigant

Biomolecules· June 2016

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Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery.
Yuxi Wang, Hang Zhang, Benoît Gigant, Yamei Yu, Yangping Wu

FEBS J· January 2016

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Kinesin, 30 years later: Recent insights from structural studies.
Weiyi Wang, Luyan Cao, Chunguang Wang, Benoît Gigant, Marcel Knossow

Protein Sci· July 2015

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New Insights into the Coupling between Microtubule Depolymerization and ATP Hydrolysis by Kinesin-13 Protein Kif2C.
Weiyi Wang, Ting Shen, Raphael Guerois, Fuming Zhang, Hureshitanmu Kuerban, Benoît Gigant

J Biol Chem· July 2015

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The structure of apo-kinesin bound to tubulin links the nucleotide cycle to movement.
Luyan Cao, Weiyi Wang, Qiyang Jiang, Chunguang Wang, Marcel Knossow, Benoît Gigant

Nat Commun· November 2014

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Mechanism of Tau-promoted microtubule assembly as probed by NMR spectroscopy.
Benoît Gigant, Isabelle Landrieu, Caroline Fauquant, Pascale Barbier, Isabelle Huvent

J Am Chem Soc· September 2014

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