Publications by authors named "Charles Eyermann"

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Small molecule inhibitors of mannan-binding lectin-associated serine Proteases-2 and-3.
Mina C Nakhla, Janelle Comita, Adam B Shapiro, Samir H Moussa, April Chen, Charles J Eyermann

Eur J Med Chem· May 2025

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Design of Novel Mercapto-3-phenylpropanoyl Dipeptides as Dual Angiotensin-Converting Enzyme C-Domain-Selective/Neprilysin Inhibitors.
Gyles E Cozier, Lauren B Coulson, Charles J Eyermann, Gregory S Basarab, Sylva L Schwager

J Med Chem· April 2025

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Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Melissa L Boby, Daren Fearon, Matteo Ferla, Mihajlo Filep, Lizbé Koekemoer, Charles J Eyermann

Science· November 2023

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Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity.
Preshendren Govender, Rudolf Müller, Kawaljit Singh, Virsinha Reddy, Charles J Eyermann

J Med Chem· May 2022

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Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition.
Lauren B Arendse, Gyles E Cozier, Charles J Eyermann, Gregory S Basarab, Sylva L Schwager

J Med Chem· February 2022

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1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in .
Lutete Peguy Khonde, Rudolf Müller, Grant A Boyle, Virsinha Reddy, Aloysius T Nchinda, Charles J Eyermann

J Med Chem· September 2021

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High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.
Hector Newman, Alen Krajnc, Dom Bellini, Charles J Eyermann, Grant A Boyle

J Med Chem· August 2021

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Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening.
Esther C Y Lee, Andrew J McRiner, Katy E Georgiadis, Julie Liu, Zooey Wang, Charles J Eyermann

J Med Chem· May 2021

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Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.
Candice Soares de Melo, Vinayak Singh, Alissa Myrick, Sandile B Simelane, Dale Taylor, Charles J Eyermann

J Med Chem· January 2021

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Structural Basis for Inhibitor Potency and Selectivity of Phosphatidylinositol 4-Kinase Inhibitors.
Stephen Fienberg, Charles J Eyermann, Lauren B Arendse, Gregory S Basarab, Jacob A McPhail

ACS Infect Dis· November 2020

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Brainwide Genetic Sparse Cell Labeling to Illuminate the Morphology of Neurons and Glia with Cre-Dependent MORF Mice.
Matthew B Veldman, Chang Sin Park, Charles M Eyermann, Jason Y Zhang, Elizabeth Zuniga-Sanchez

Neuron· October 2020

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Antibacterial Spiropyrimidinetriones with N-Linked Azole Substituents on a Benzisoxazole Scaffold Targeting DNA Gyrase.
Gregory S Basarab, Peter Doig, Charles J Eyermann, Vincent Galullo, Gunther Kern

J Med Chem· October 2020

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Lerisetron Analogues with Antimalarial Properties: Synthesis, Structure-Activity Relationship Studies, and Biological Assessment.
Rudolf Mueller, Virsinha Reddy, Aloysius T Nchinda, Fanuel Mebrahtu, Dale Taylor, Charles J Eyermann

ACS Omega· March 2020

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Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains.
Claire Le Manach, Tanya Paquet, Kathryn Wicht, Aloysius T Nchinda, Christel Brunschwig, Charles J Eyermann

J Med Chem· October 2018

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Plasmodial Kinase Inhibitors: License to Cure?
Diego González Cabrera, André Horatscheck, Colin R Wilson, Greg Basarab, Charles J Eyermann

J Med Chem· September 2018

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Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria.
Nishanth Kandepedu, Diego Gonzàlez Cabrera, Srinivas Eedubilli, Dale Taylor, Christel Brunschwig, Charles J Eyermann

J Med Chem· July 2018

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Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping.
David C McKinney, Charles J Eyermann, Rong-Fang Gu, Jun Hu, Steven L Kazmirski

ACS Infect Dis· July 2016

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Negishi cross-coupling enabled synthesis of novel NAD(+)-dependent DNA ligase inhibitors and SAR development.
Kerry E Murphy-Benenato, Lakshmaiah Gingipalli, P Ann Boriack-Sjodin, Gabriel Martinez-Botella, Dan Carcanague, Charles J Eyermann

Bioorg Med Chem Lett· November 2015

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Genetic and chemical validation identifies Mycobacterium tuberculosis topoisomerase I as an attractive anti-tubercular target.
Sudha Ravishankar, Anisha Ambady, Disha Awasthy, Naina Vinay Mudugal, Sreenivasaiah Menasinakai, Charles J Eyermann

Tuberculosis (Edinb)· September 2015

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4,5-Disubstituted 6-Aryloxy-1,3-dihydrobenzo[c][1,2]oxaboroles Are Broad-Spectrum Serine β-Lactamase Inhibitors.
David C McKinney, Fei Zhou, Charles J Eyermann, Andrew D Ferguson, D Bryan Prince

ACS Infect Dis· July 2015

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X-ray crystal structures of Escherichia coli RNA polymerase with switch region binding inhibitors enable rational design of squaramides with an improved fraction unbound to human plasma protein.
Vadim Molodtsov, Paul R Fleming, Charles J Eyermann, Andrew D Ferguson, Melinda A Foulk

J Med Chem· April 2015

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Pyrazolopyrimidines establish MurC as a vulnerable target in Pseudomonas aeruginosa and Escherichia coli.
Shahul Hameed P, Praveena Manjrekar, Murugan Chinnapattu, Vaishali Humnabadkar, Gajanan Shanbhag, Charles J Eyermann

ACS Chem Biol· October 2014

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Optimization of physicochemical properties and safety profile of novel bacterial topoisomerase type II inhibitors (NBTIs) with activity against Pseudomonas aeruginosa.
Folkert Reck, David E Ehmann, Thomas J Dougherty, Joseph V Newman, Sussie Hopkins, Charles J Eyermann

Bioorg Med Chem· October 2014

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High-throughput identification of promiscuous inhibitors from screening libraries with the use of a thiol-containing fluorescent probe.
Megan M McCallum, Premchendar Nandhikonda, Jonathan J Temmer, Charles Eyermann, Anton Simeonov

J Biomol Screen· July 2013

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Design of inhibitors of Helicobacter pylori glutamate racemase as selective antibacterial agents: incorporation of imidazoles onto a core pyrazolopyrimidinedione scaffold to improve bioavailabilty.
Gregory S Basarab, Pamela Hill, Charles J Eyermann, Madhu Gowravaram, Helena Käck

Bioorg Med Chem Lett· September 2012

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