Publications by authors named "Chien-Huang Lin"

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Role of C/EBPβ/STAT3/AP-1 transcriptional complex formation in thrombin-induced connective tissue growth factor expression in human lung fibroblasts.
Hung-Sheng Hua, Yi-Ting Huang, Hong-Sheng Lee, Chia-Hao Liu, Wei Chao, Chien-Huang Lin

Eur J Pharmacol· November 2025

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Serine/threonine kinase 33 mediates thrombin-induced interleukin-8 release from human lung epithelial cells in severe asthma.
Wun-Hao Cheng, Wen-Shan Chang, Po-Hao Feng, Kuan-Yuan Chen, Kang-Yun Lee, Lee-Yuan Lin, Chien-Huang Lin

Respir Res· October 2025

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Involvement of ADAM17-dependent MUC1-CT activation in TGF-β-induced EZH2 expression in human lung fibroblasts and in ovalbumin-induced airway fibrosis in mice.
Hung-Sheng Hua, Jing-Jing You, Yu-Chih Wu, Jing-Yun Chen, Hong-Sheng Lee, Chien-Huang Lin

Biochem Pharmacol· September 2025

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MPT0E028, a novel pan-HDAC inhibitor, prevents pulmonary fibrosis through inhibition of TGF-β-induced CTGF expression in human lung fibroblasts: Involvement of MKP-1 activation.
Chia-Hao Liu, Hong-Sheng Lee, Jing-Ping Liou, Hung-Sheng Hua, Wun-Hao Cheng, Chien-Huang Lin

Eur J Pharmacol· August 2024

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Neutralization of CX3CL1 Attenuates TGF-β-Induced Fibroblast Differentiation Through NF-κB Activation and Mitochondrial Dysfunction in Airway Fibrosis.
Wun-Hao Cheng, Pao-Lung Chang, Yu-Chih Wu, Shao-An Wang, Chia-Ling Chen, Feng-Lin Hsu, Lee-Yuan Lin, Chien-Huang Lin

Lung· June 2024

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Airway epithelium IgE-FcεRI cross-link induces epithelial barrier disruption in severe T2-high asthma.
Chih-Ming Weng, Meng-Jung Lee, Wei Chao, Yuh-Rong Lin, Chun-Ju Chou, I-Lin Tsai, Chien-Huang Lin

Mucosal Immunol· October 2023

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Endothelin-1 induces connective tissue growth factor expression in human lung fibroblasts by disrupting HDAC2/Sin3A/MeCP2 corepressor complex.
Hung-Sheng Hua, Heng-Ching Wen, Hong-Sheng Lee, Chih-Ming Weng, Fara Silvia Yuliani, Chien-Huang Lin

J Biomed Sci· June 2023

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Amphiregulin induces CCN2 and fibronectin expression by TGF-β through EGFR-dependent pathway in lung epithelial cells.
Wun-Hao Cheng, Shih-Ya Kao, Chia-Ling Chen, Fara Silvia Yuliani, Lee-Yuan Lin, Chien-Huang Lin

Respir Res· December 2022

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Thrombin induces IL-8/CXCL8 expression by DCLK1-dependent RhoA and YAP activation in human lung epithelial cells.
Fara Silvia Yuliani, Jing-Yun Chen, Wen-Hao Cheng, Heng-Ching Wen, Bing-Chang Chen, Chien-Huang Lin

J Biomed Sci· November 2022

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Platelet Activation in High D-Dimer Plasma Plays a Role in Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients with Mutant Lung Adenocarcinoma.
Meng-Jung Lee, Chih-Ming Weng, Wei Chao, Yueh-Fu Fang, Fu-Tsai Chung, Chien-Huang Lin

Front Oncol· June 2022

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A Potent Histone Deacetylase Inhibitor MPT0E028 Mitigates Emphysema Severity via Components of the Hippo Signaling Pathway in an Emphysematous Mouse Model.
Lu-Yang Yeh, Yu-Ting Fang, Hong-Sheng Lee, Chia-Hao Liu, You-Yin Chen, Chien-Huang Lin

Front Med (Lausanne)· May 2022

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Pref-1 induced lung fibroblast differentiation by hypoxia through integrin α5β1/ERK/AP-1 cascade.
Wun-Hao Cheng, Kang-Yun Lee, Ming-Chih Yu, Jing-Yun Chen, Chien-Huang Lin

Eur J Pharmacol· October 2021

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Abnormal ADAM17 expression causes airway fibrosis in chronic obstructive asthma.
Jing-Yun Chen, Wun-Hao Cheng, Kang-Yun Lee, Han-Pin Kuo, Kian Fan Chung, Chia-Ling Chen, Chien-Huang Lin

Biomed Pharmacother· August 2021

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Synthesis and biological evaluation of phenothiazine derivative-containing hydroxamic acids as potent class II histone deacetylase inhibitors.
Kai-Cheng Hsu, Jung-Chun Chu, Hui-Ju Tseng, Chia-I Liu, Hao-Ching Wang, Tony Eight Lin, Ling-Wei Hsin, Chien-Huang Lin

Eur J Med Chem· July 2021

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Hypoxia-induced preadipocyte factor 1 expression in human lung fibroblasts through ERK/PEA3/c-Jun pathway.
Wun-Hao Cheng, Chia-Ling Chen, Jing-Yun Chen, Chien-Huang Lin, Bing-Chang Chen

Mol Med· July 2021

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Histone deacetylase 7 mediates endothelin-1-induced connective tissue growth factor expression in human lung fibroblasts through p300 and activator protein-1 activation.
Hung-Sheng Hua, Heng-Ching Wen, Chih-Ming Weng, Hong-Sheng Lee, Bing-Chang Chen, Chien-Huang Lin

J Biomed Sci· May 2021

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TGF-β Induced CTGF Expression in Human Lung Epithelial Cells through ERK, ADAM17, RSK1, and C/EBPβ Pathways.
Shu-Ching Ou, Kuan-Jen Bai, Wun-Hao Cheng, Jing-Yun Chen, Chien-Huang Lin

Int J Mol Sci· November 2020

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Mammalian target of rapamycin and p70S6K mediate thrombin-induced nuclear factor-κB activation and IL-8/CXCL8 release in human lung epithelial cells.
Chien-Huang Lin, Chung-Hung Shih, Chun-Ping Jiang, Heng-Ching Wen, Wun-Hao Cheng

Eur J Pharmacol· February 2020

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induces connective tissue growth factor expression through the TLR2-JNK-AP-1 pathway in human lung fibroblasts.
Hong-Sheng Lee, Hung-Sheng Hua, Cheng-Hui Wang, Ming-Chih Yu, Bing-Chang Chen, Chien-Huang Lin

FASEB J· November 2019

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Activation of PERK in ET-1- and thrombin-induced pulmonary fibroblast differentiation: Inhibitory effects of curcumin.
Yen-Chou Chen, Bing-Chang Chen, Huei-Mei Huang, Shin-Hua Lin, Chien-Huang Lin

J Cell Physiol· September 2019

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How Self-Construals Affect Responses to Anthropomorphic Brands, With a Focus on the Three-Factor Relationship Between the Brand, the Gift-Giver and the Recipient.
Chien-Huang Lin, Yidan Huang

Front Psychol· November 2018

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ADAM17/EGFR-dependent ERK activation mediates thrombin-induced CTGF expression in human lung fibroblasts.
Hui-Yu Chen, Chien-Huang Lin, Bing-Chang Chen

Exp Cell Res· September 2018

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MEKK1, JNK, and SMAD3 mediate CXCL12-stimulated connective tissue growth factor expression in human lung fibroblasts.
Chien-Huang Lin, Chung-Huang Shih, Yu-Chang Lin, You-Lan Yang, Bing-Chang Chen

J Biomed Sci· March 2018

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Follow Your Heart: How Is Willingness to Pay Formed under Multiple Anchors?
Chien-Huang Lin, Ming Chen

Front Psychol· December 2017

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Correction: Induction of Connective Tissue Growth Factor Expression by Hypoxia in Human Lung Fibroblasts via the MEKK1/MEK1/ERK1/GLI-1/GLI-2 and AP-1 Pathways.
Yi Cheng, Chien-Huang Lin, Jing-Yun Chen, Chien-Hua Li, Yu-Tin Liu

PLoS One· November 2017

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