Publications by authors named "Christopher F Higgins"

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Production of P-glycoprotein from the MDR1 upstream promoter is insufficient to affect the response to first-line chemotherapy in advanced breast cancer.
Selina Raguz, Rebecca A Randle, Eva R Sharpe, John A Foekens, Anieta M Sieuwerts, Christopher F Higgins

Int J Cancer· March 2008

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Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death.
Simon R J Taylor, Mireya Gonzalez-Begne, Stephen Dewhurst, Giovanna Chimini, Christopher F Higgins

J Immunol· January 2008

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Role of the highly structured 5'-end region of MDR1 mRNA in P-glycoprotein expression.
Rebecca A Randle, Selina Raguz, Christopher F Higgins, Ernesto Yagüe

Biochem J· September 2007

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Multiple molecular mechanisms for multidrug resistance transporters.
Christopher F Higgins

Nature· April 2007

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Regulatory T cells are resistant to apoptosis via TCR but not P2X7.
Simon R J Taylor, Denis R Alexander, Joanne C Cooper, Christopher F Higgins, James I Elliott

J Immunol· March 2007

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ClC-3 expression enhances etoposide resistance by increasing acidification of the late endocytic compartment.
Karsten H Weylandt, Maxim Nebrig, Nils Jansen-Rosseck, Joanna S Amey, David Carmena, Christopher F Higgins

Mol Cancer Ther· March 2007

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Structure and function of ABC transporters: the ATP switch provides flexible control.
Kenneth J Linton, Christopher F Higgins

Pflugers Arch· February 2007

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Twenty years of ATP-binding cassette (ABC) transporters.
Bruno Stieger, Christopher F Higgins

Pflugers Arch· February 2007

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Ability to acquire drug resistance arises early during the tumorigenesis process.
Ernesto Yagüe, Ana Arance, Loïc Kubitza, Michael O'Hare, Parmjit Jat, Christopher F Higgins

Cancer Res· February 2007

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The human ClC-4 protein, a member of the CLC chloride channel/transporter family, is localized to the endoplasmic reticulum by its N-terminus.
Hanneke Okkenhaug, Karsten-Henrich Weylandt, David Carmena, Dominic J Wells, Christopher F Higgins

FASEB J· November 2006

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Phosphatidylserine exposure in B lymphocytes: a role for lipid packing.
James I Elliott, Alessandro Sardini, Joanne C Cooper, Denis R Alexander, Suzel Davanture, Christopher F Higgins

Blood· September 2006

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Role for centromeric heterochromatin and PML nuclear bodies in the cellular response to foreign DNA.
Cleo L Bishop, Michal Ramalho, Nachiket Nadkarni, Wing May Kong, Christopher F Higgins

Mol Cell Biol· April 2006

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The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products.
James I Elliott, John H McVey, Christopher F Higgins

Arthritis Res Ther· January 2006

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Expression of RPIP9 (Rap2 interacting protein 9) is activated in breast carcinoma and correlates with a poor prognosis.
Selina Raguz, Manuela Tamburo De Bella, Martin J Slade, Christopher F Higgins, R Charles Coombes

Int J Cancer· December 2005

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Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes.
James I Elliott, Annmarie Surprenant, Federica M Marelli-Berg, Joanne C Cooper, Robin L Cassady-Cain, Christopher F Higgins

Nat Cell Biol· August 2005

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A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome.
Christiane Albrecht, John H McVey, James I Elliott, Alessandro Sardini, Ildiko Kasza, Christopher F Higgins

Blood· July 2005

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Accelerated exposure of phosphatidylserine on lymphocyte populations from patients with systemic lupus erythematosus or rheumatoid arthritis.
Christiane Albrecht, Soni Soumian, Raymond Playford, Christopher F Higgins, Timothy Vyse

Thromb Haemost· May 2005

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Three-dimensional structure of P-glycoprotein: the transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state.
Mark F Rosenberg, Richard Callaghan, Szabolcs Modok, Christopher F Higgins, Robert C Ford

J Biol Chem· January 2005

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Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome.
Gail S Begley, Andrea R Horvath, Jenny C Taylor, Christopher F Higgins

Mol Immunol· January 2005

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Multidrug transporter activity in lymphocytes.
James I Elliott, Selina Raguz, Christopher F Higgins

Br J Pharmacol· December 2004

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Extracellular acidification elicits a chloride current that shares characteristics with ICl(swell).
Muriel Nobles, Christopher F Higgins, Alessandro Sardini

Am J Physiol Cell Physiol· November 2004

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The ATP switch model for ABC transporters.
Christopher F Higgins, Kenneth J Linton

Nat Struct Mol Biol· October 2004

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Major histocompatibility complex class I shedding and programmed cell death stimulated through the proinflammatory P2X7 receptor: a candidate susceptibility gene for NOD diabetes.
James I Elliott, Christopher F Higgins

Diabetes· August 2004

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Two novel missense mutations in ABCA1 result in altered trafficking and cause severe autosomal recessive HDL deficiency.
Christiane Albrecht, Kevin Baynes, Alessandro Sardini, Silke Schepelmann, Emily R Eden, Christopher F Higgins

Biochim Biophys Acta· May 2004

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Activation of the MDR1 upstream promoter in breast carcinoma as a surrogate for metastatic invasion.
Selina Raguz, Manuela Tamburo De Bella, Gopichani Tripuraneni, Martin J Slade, Christopher F Higgins

Clin Cancer Res· April 2004

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