Publications by authors named "Christopher Gabel"

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IPSC-based modeling of resiliency in centenarians reveals longevity-specific signatures.
Todd W Dowrey, Samuel F Cranston, Nicholas J Skvir, Yvonne Lok, Payton Bock, Christopher V Gabel

bioRxiv· October 2025

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Profile of NT-0527, a brain penetrant NLRP3 Inflammasome inhibitor suitable as an tool compound for neuroinflammatory disorders.
David Harrison, Andy Billinton, Mark G Bock, Nicholas P Clarke, Zsofia Digby, Christopher A Gabel

RSC Med Chem· September 2025

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Global excitatory synchrony: Ketamine induces global common-mode excitatory network oscillation by decoupling key interneurons.
Belen Karakullukcu, Hamilton White, Christopher Connor, Christopher Gabel

bioRxiv· August 2025

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CaNetiCs - An Open-Source Toolbox for Standardized Dimensionality Reduction of Neuronal Calcium Activity.
Daniel Carbonero, Jad Noueihed, Christopher V Gabel, Mark A Kramer, John A White

bioRxiv· August 2025

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Anesthesia isn't sleep: The neuronal dynamics of immobility in isoflurane-anesthetized C. elegans differ from the activity patterns of previously established sleep-like quiescent states.
Andrew S Chang, Laura Mazuera, Christopher V Gabel, Christopher W Connor

PLoS One· May 2025

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The ester-containing prodrug NT-0796 enhances delivery of the NLRP3 inflammasome inhibitor NDT-19795 to monocytic cells expressing carboxylesterase-1.
John R Doedens, Christine Diamond, David Harrison, Mark G Bock, Nicholas Clarke, Christopher A Gabel

Biochem Pharmacol· September 2024

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EventLFM: event camera integrated Fourier light field microscopy for ultrafast 3D imaging.
Ruipeng Guo, Qianwan Yang, Andrew S Chang, Guorong Hu, Joseph Greene, Christopher V Gabel

Light Sci Appl· June 2024

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Pharmacological Analysis of NLRP3 Inflammasome Inhibitor Sodium [(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl][(1-methyl-1-pyrazol-4-yl)({[(2)-oxolan-2-yl]methyl})sulfamoyl]azanide in Cellular and Mouse Models of Inflammation Provides a Translational Framework.
John R Doedens, Pamela Smolak, MyTrang Nguyen, Heather Wescott, Christine Diamond, Christopher A Gabel

ACS Pharmacol Transl Sci· May 2024

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Species-specific NLRP3 regulation and its role in CNS autoinflammatory diseases.
Beverly H Koller, MyTrang Nguyen, John N Snouwaert, Christopher A Gabel, Jenny P-Y Ting

Cell Rep· March 2024

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Target Cell Activation of a Structurally Novel NOD-Like Receptor Pyrin Domain-Containing Protein 3 Inhibitor NT-0796 Enhances Potency.
Pamela Smolak, MyTrang Nguyen, Christine Diamond, Heather Wescott, John R Doedens, Christopher A Gabel

J Pharmacol Exp Ther· February 2024

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O-GlcNAc signaling increases neuron regeneration through one-carbon metabolism in .
Dilip Kumar Yadav, Andrew C Chang, Noa W F Grooms, Samuel H Chung, Christopher V Gabel

Elife· February 2024

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Discovery of Clinical Candidate NT-0796, a Brain-Penetrant and Highly Potent NLRP3 Inflammasome Inhibitor for Neuroinflammatory Disorders.
David Harrison, Andy Billinton, Mark G Bock, John R Doedens, Christopher A Gabel

J Med Chem· November 2023

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Measures of Information Content during Anesthesia and Emergence in the Caenorhabditis elegans Nervous System.
Andrew S Chang, Gregory S Wirak, Duan Li, Christopher V Gabel, Christopher W Connor

Anesthesiology· July 2023

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Discovery and Optimization of Triazolopyrimidinone Derivatives as Selective NLRP3 Inflammasome Inhibitors.
David Harrison, Mark G Bock, John R Doedens, Christopher A Gabel, M Katharine Holloway

ACS Med Chem Lett· August 2022

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Age-associated changes to neuronal dynamics involve a disruption of excitatory/inhibitory balance in .
Gregory S Wirak, Jeremy Florman, Mark J Alkema, Christopher W Connor, Christopher V Gabel

Elife· June 2022

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Wide field-of-view volumetric imaging by a mesoscopic scanning oblique plane microscopy with switchable objective lenses.
Wenjun Shao, Kivilcim Kilic, Wenqing Yin, Gregory Wirak, Xiaodan Qin, Christopher V Gabel

Quant Imaging Med Surg· March 2021

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Discovery of a series of ester-substituted NLRP3 inflammasome inhibitors.
David Harrison, Nicolas Boutard, Krzysztof Brzozka, Marta Bugaj, Stefan Chmielewski, Christopher A Gabel

Bioorg Med Chem Lett· December 2020

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Isoflurane Exposure in Juvenile Caenorhabditis elegans Causes Persistent Changes in Neuron Dynamics.
Gregory S Wirak, Christopher V Gabel, Christopher W Connor

Anesthesiology· September 2020

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Collapse of Global Neuronal States in Caenorhabditis elegans under Isoflurane Anesthesia.
Mehraj R Awal, Gregory S Wirak, Christopher V Gabel, Christopher W Connor

Anesthesiology· July 2020

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LED array reflectance microscopy for scattering-based multi-contrast imaging.
Weiye Song, Alex Matlock, Sipei Fu, Xiaodan Qin, Hui Feng, Christopher V Gabel

Opt Lett· April 2020

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Sustained Ca2+ mobilizations: A quantitative approach to predict their importance in cell-cell communication and wound healing.
Yoonjoo Lee, Min Tae Kim, Garrett Rhodes, Kelsey Sack, Sung Jun Son, Christopher V Gabel

PLoS One· December 2019

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Wedge prism approach for simultaneous multichannel microscopy.
Hanna Cai, Yao L Wang, Richard T Wainner, Nicusor V Iftimia, Christopher V Gabel

Sci Rep· November 2019

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CED-4 CARD domain residues can modulate non-apoptotic neuronal regeneration functions independently from apoptosis.
Guoqiang Wang, Lin Sun, Christopher P Reina, Isaac Song, Christopher V Gabel

Sci Rep· September 2019

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Video-rate large-scale imaging with Multi-Z confocal microscopy.
Amaury Badon, Seth Bensussen, Howard J Gritton, Mehraj R Awal, Christopher V Gabel

Optica· April 2019

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O-GlcNAc Signaling Orchestrates the Regenerative Response to Neuronal Injury in Caenorhabditis elegans.
Daniel G Taub, Mehraj R Awal, Christopher V Gabel

Cell Rep· August 2018

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