Publications by authors named "Conrad Cowan"

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Identifying internal and external shoulder rotation using a kirigami-based shoulder patch.
Amani A Alkayyali, Conrad P F Cowan, Callum J Owen, Emmanuel Giannas, Susann Wolfram

Wearable Technol· December 2024

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TRV0109101, a G Protein-Biased Agonist of the -Opioid Receptor, Does Not Promote Opioid-Induced Mechanical Allodynia following Chronic Administration.
Michael Koblish, Richard Carr, Edward R Siuda, David H Rominger, William Gowen-MacDonald, Conrad L Cowan

J Pharmacol Exp Ther· August 2017

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Long-Term Biased β-Arrestin Signaling Improves Cardiac Structure and Function in Dilated Cardiomyopathy.
David M Ryba, Jieli Li, Conrad L Cowan, Brenda Russell, Beata M Wolska

Circulation· March 2017

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Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model.
Madhusudhan Tarigopula, Robert T Davis, Paul T Mungai, David M Ryba, David F Wieczorek, Conrad L Cowan

Cardiovasc Res· July 2015

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Biased ligands: pathway validation for novel GPCR therapeutics.
David H Rominger, Conrad L Cowan, William Gowen-MacDonald, Jonathan D Violin

Curr Opin Pharmacol· June 2014

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First clinical experience with TRV130: pharmacokinetics and pharmacodynamics in healthy volunteers.
David G Soergel, Ruth Ann Subach, Brian Sadler, John Connell, Alan S Marion, Conrad L Cowan

J Clin Pharmacol· March 2014

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Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain.
Xiao-Tao Chen, Philip Pitis, Guodong Liu, Catherine Yuan, Dimitar Gotchev, Conrad L Cowan

J Med Chem· October 2013

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First clinical experience with TRV027: pharmacokinetics and pharmacodynamics in healthy volunteers.
David G Soergel, Ruth Ann Subach, Conrad L Cowan, Jonathan D Violin, Michael W Lark

J Clin Pharmacol· September 2013

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A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine.
Scott M DeWire, Dennis S Yamashita, David H Rominger, Guodong Liu, Conrad L Cowan

J Pharmacol Exp Ther· March 2013

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Synthesis and evaluation of potent and selective beta3 adrenergic receptor agonists containing heterobiaryl carboxylic acids.
Barry G Shearer, Esther Y Chao, David E Uehling, David N Deaton, Conrad Cowan

Bioorg Med Chem Lett· August 2007

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Biarylaniline phenethanolamines as potent and selective beta3 adrenergic receptor agonists.
David E Uehling, Barry G Shearer, Kelly H Donaldson, Esther Y Chao, David N Deaton, Conrad Cowan

J Med Chem· May 2006

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Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.
Diane Gesty-Palmer, Minyong Chen, Eric Reiter, Seungkirl Ahn, Christopher D Nelson, Conrad L Cowan

J Biol Chem· April 2006

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Quantitative cell-based high-content screening for vasopressin receptor agonists using transfluor technology.
Richik N Ghosh, Richard DeBiasio, Christine C Hudson, Everett R Ramer, Conrad L Cowan

J Biomol Screen· August 2005

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Synthesis and evaluation of potent and selective beta(3) adrenergic receptor agonists containing acylsulfonamide, sulfonylsulfonamide, and sulfonylurea carboxylic acid isosteres.
David E Uehling, Kelly H Donaldson, David N Deaton, Clifton E Hyman, Elizabeth E Sugg, Conrad Cowan

J Med Chem· January 2002

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