Publications by authors named "Dagmar Schlenzig"

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Synthesis and structure-activity relationships of pyrazole-based inhibitors of meprin α and β.
Kathrin Tan, Christian Jäger, Stefanie Geissler, Dagmar Schlenzig, Mirko Buchholz

J Enzyme Inhib Med Chem· December 2023

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Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor.
Charles Bayly-Jones, Christopher J Lupton, Claudia Fritz, Hariprasad Venugopal, Daniel Ramsbeck, Dagmar Schlenzig

Nat Commun· October 2022

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Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor.
Miriam Linnert, Claudia Fritz, Christian Jäger, Dagmar Schlenzig, Daniel Ramsbeck

Int J Mol Sci· May 2021

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Heteroaromatic Inhibitors of the Astacin Proteinases Meprin α, Meprin β and Ovastacin Discovered by a Scaffold-Hopping Approach.
Kathrin Tan, Christian Jäger, Hagen Körschgen, Stefanie Geissler, Dagmar Schlenzig

ChemMedChem· March 2021

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Dipeptidyl-Peptidase Activity of Meprin β Links N-truncation of Aβ with Glutaminyl Cyclase-Catalyzed pGlu-Aβ Formation.
Dagmar Schlenzig, Holger Cynis, Maike Hartlage-Rübsamen, Ulrike Zeitschel, Katja Menge

J Alzheimers Dis· September 2019

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Continuous assays for meprin alpha and beta using prolyl tripeptidyl aminopeptidase (PtP) from Porphyromonas gingivalis.
Anja Schulze, Michael Wermann, Hans-Ulrich Demuth, Tadashi Yoshimoto, Daniel Ramsbeck, Dagmar Schlenzig

Anal Biochem· October 2018

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Tertiary-Amine-Based Inhibitors of the Astacin Protease Meprin α.
Kathrin Tan, Christian Jäger, Dagmar Schlenzig, Stephan Schilling, Mirko Buchholz

ChemMedChem· August 2018

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Structure-Guided Design, Synthesis, and Characterization of Next-Generation Meprin β Inhibitors.
Daniel Ramsbeck, Antje Hamann, Georg Richter, Dagmar Schlenzig, Stefanie Geissler

J Med Chem· May 2018

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Heterologous Expression of the Astacin Protease Meprin β in Pichia pastoris.
Dagmar Schlenzig, Stephan Schilling

Methods Mol Biol· February 2018

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Concerted action of dipeptidyl peptidase IV and glutaminyl cyclase results in formation of pyroglutamate-modified amyloid peptides in vitro.
Alvard Antonyan, Dagmar Schlenzig, Stephan Schilling, Marcel Naumann, Svetlana Sharoyan

Neurochem Int· February 2018

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Purification of recombinant Aβ(1-42) and pGlu-Aβ(3-42) using preparative SDS-PAGE.
Claudia Spahn, Michael Wermann, Rico Eichentopf, Gerd Hause, Dagmar Schlenzig

Electrophoresis· August 2017

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First insight into structure-activity relationships of selective meprin β inhibitors.
Daniel Ramsbeck, Antje Hamann, Dagmar Schlenzig, Stephan Schilling, Mirko Buchholz

Bioorg Med Chem Lett· June 2017

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Neuropeptide Y (NPY) in cerebrospinal fluid from patients with Huntington's Disease: increased NPY levels and differential degradation of the NPY1-30 fragment.
Leona Wagner, Maria Björkqvist, Sofia Hult Lundh, Raik Wolf, Arne Börgel, Dagmar Schlenzig

J Neurochem· June 2016

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Enhanced Fibril Fragmentation of N-Terminally Truncated and Pyroglutamyl-Modified Aβ Peptides.
Melanie Wulff, Monika Baumann, Anka Thümmler, Jay K Yadav, Liesa Heinrich, Dagmar Schlenzig

Angew Chem Int Ed Engl· April 2016

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Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novel NPY-cleaving peptidases and potential drug interactions in CNS and Periphery.
Leona Wagner, Raik Wolf, Ulrike Zeitschel, Steffen Rossner, Åsa Petersén, Dagmar Schlenzig

J Neurochem· December 2015

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N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation.
Dagmar Schlenzig, Raik Rönicke, Holger Cynis, Hans-Henning Ludwig, Eike Scheel

J Neurochem· June 2012

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Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus.
Torsten Geissler, Wolfgang Brandt, Andrea Porzel, Dagmar Schlenzig, Astrid Kehlen

Bioorg Med Chem· March 2010

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Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides.
Dagmar Schlenzig, Susanne Manhart, Yeliz Cinar, Martin Kleinschmidt, Gerd Hause

Biochemistry· July 2009

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Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.
Stephan Schilling, Ulrike Zeitschel, Torsten Hoffmann, Ulrich Heiser, Mike Francke, Dagmar Schlenzig

Nat Med· October 2008

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Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor.
Christoph Parthier, Martin Kleinschmidt, Piotr Neumann, Rainer Rudolph, Susanne Manhart, Dagmar Schlenzig

Proc Natl Acad Sci U S A· August 2007

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Acylated hydroxamates as selective and highly potent inhibitors of dipeptidyl peptidase I.
André J Niestroj, Dagmar Schlenzig, Ulrich Heiser, Kerstin Kühn-Wache, Blas Cigic

Adv Exp Med Biol· July 2003

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