Publications by authors named "Michael Wermann"

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Monomers, Dimers, and Oligomers of Pyroglutamate-Modified α-Synuclein Fragments Exhibit Distinct Biophysical Characteristics.
Alexandra Bluhm, Wei Xiang, Frank Wien, Aurelien Thureau, Maelenn Chevreuil, Michael Wermann

ACS Chem Neurosci· May 2025

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Identification of isoaspartate-modified transthyretin as potential target for selective immunotherapy of transthyretin amyloidosis.
Janett Köppen, Martin Kleinschmidt, Markus Morawski, Jens-Ulrich Rahfeld, Michael Wermann

Amyloid· September 2024

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Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor.
Charles Bayly-Jones, Christopher J Lupton, Claudia Fritz, Hariprasad Venugopal, Daniel Ramsbeck, Michael Wermann

Nat Commun· October 2022

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Immunogenicity of the Envelope Surface Unit of Human Endogenous Retrovirus K18 in Mice.
Victoria Ilse, Rebekka Scholz, Michael Wermann, Marcel Naumann, Martin S Staege

Int J Mol Sci· July 2022

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Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor.
Miriam Linnert, Claudia Fritz, Christian Jäger, Dagmar Schlenzig, Daniel Ramsbeck, Michael Wermann

Int J Mol Sci· May 2021

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Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro.
Janett Köppen, Anja Schulze, Lisa Machner, Michael Wermann, Rico Eichentopf

Molecules· January 2020

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Dipeptidyl-Peptidase Activity of Meprin β Links N-truncation of Aβ with Glutaminyl Cyclase-Catalyzed pGlu-Aβ Formation.
Dagmar Schlenzig, Holger Cynis, Maike Hartlage-Rübsamen, Ulrike Zeitschel, Katja Menge, Michael Wermann

J Alzheimers Dis· September 2019

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Continuous assays for meprin alpha and beta using prolyl tripeptidyl aminopeptidase (PtP) from Porphyromonas gingivalis.
Anja Schulze, Michael Wermann, Hans-Ulrich Demuth, Tadashi Yoshimoto, Daniel Ramsbeck

Anal Biochem· October 2018

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Purification of recombinant Aβ(1-42) and pGlu-Aβ(3-42) using preparative SDS-PAGE.
Claudia Spahn, Michael Wermann, Rico Eichentopf, Gerd Hause, Dagmar Schlenzig

Electrophoresis· August 2017

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Probing secondary glutaminyl cyclase (QC) inhibitor interactions applying an in silico-modeling/site-directed mutagenesis approach: implications for drug development.
Birgit Koch, Mirko Buchholz, Michael Wermann, Ulrich Heiser, Stephan Schilling

Chem Biol Drug Des· December 2012

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Crystal structures of glutaminyl cyclases (QCs) from Drosophila melanogaster reveal active site conservation between insect and mammalian QCs.
Birgit Koch, Petr Kolenko, Mirko Buchholz, David Ruiz Carrillo, Christoph Parthier, Michael Wermann

Biochemistry· September 2012

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The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.
Holger Cynis, Torsten Hoffmann, Daniel Friedrich, Astrid Kehlen, Kathrin Gans, Michael Wermann

EMBO Mol Med· September 2011

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Isolation of dipeptidyl peptidase IV (DP 4) isoforms from porcine kidney by preparative isoelectric focusing to improve crystallization.
Leona Wagner, Michael Wermann, Fred Rosche, Jens-Ulrich Rahfeld, Torsten Hoffmann

Biol Chem· July 2011

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Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center.
David Ruiz-Carrillo, Birgit Koch, Christoph Parthier, Michael Wermann, Tresfore Dambe

Biochemistry· July 2011

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Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain.
Maike Hartlage-Rübsamen, Katharina Staffa, Alexander Waniek, Michael Wermann, Torsten Hoffmann

Int J Dev Neurosci· December 2009

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Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics.
Anett Stephan, Michael Wermann, Alex von Bohlen, Birgit Koch, Holger Cynis

FEBS J· November 2009

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Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ.
Stephan Schilling, Thomas Appl, Torsten Hoffmann, Holger Cynis, Katrin Schulz, Michael Wermann

J Neurochem· August 2008

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Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery.
Holger Cynis, Jens-Ulrich Rahfeld, Anett Stephan, Astrid Kehlen, Birgit Koch, Michael Wermann

J Mol Biol· June 2008

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Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization.
Stephan Schilling, Christiane Lindner, Birgit Koch, Michael Wermann, Jens-Ulrich Rahfeld

Biochemistry· September 2007

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Isolation and characterization of the glutaminyl cyclases from Solanum tuberosum and Arabidopsis thaliana: implications for physiological functions.
Stephan Schilling, Irene Stenzel, Alex von Bohlen, Michael Wermann, Katrin Schulz

Biol Chem· February 2007

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Does human attractin have DP4 activity?
Daniel Friedrich, Torsten Hoffmann, Joachim Bär, Michael Wermann, Susanne Manhart

Biol Chem· February 2007

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Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase.
Stephan Schilling, Holger Cynis, Alex von Bohlen, Torsten Hoffmann, Michael Wermann

Biochemistry· October 2005

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Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators.
Stephan Schilling, André J Niestroj, Jens-Ulrich Rahfeld, Torsten Hoffmann, Michael Wermann

J Biol Chem· December 2003

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Characterisation of human dipeptidyl peptidase IV expressed in Pichia pastoris. A structural and mechanistic comparison between the recombinant human and the purified porcine enzyme.
Joachim Bär, Anja Weber, Torsten Hoffmann, Jörg Stork, Michael Wermann

Biol Chem· December 2003

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The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism.
Michael Engel, Torsten Hoffmann, Leona Wagner, Michael Wermann, Ulrich Heiser

Proc Natl Acad Sci U S A· April 2003

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