Publications by authors named "Ulrich Heiser"

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Glutaminyl Cyclase Inhibitor PQ912 Improves Cognition in Mouse Models of Alzheimer's Disease-Studies on Relation to Effective Target Occupancy.
Torsten Hoffmann, Antje Meyer, Ulrich Heiser, Stephan Kurat, Livia Böhme

J Pharmacol Exp Ther· July 2017

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Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis.
Annelie Hellvard, Lutz Zeitlmann, Ulrich Heiser, Astrid Kehlen, André Niestroj

Sci Rep· August 2016

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Identifying neuropeptide Y (NPY) as the main stress-related substrate of dipeptidyl peptidase 4 (DPP4) in blood circulation.
Leona Wagner, Florian Kaestner, Raik Wolf, Harald Stiller, Ulrich Heiser

Neuropeptides· June 2016

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A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects.
Inge Lues, Frank Weber, Antje Meyer, Uli Bühring, Torsten Hoffmann, Ulrich Heiser

Alzheimers Dement (N Y)· November 2015

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Structure-activity relationships of benzimidazole-based glutaminyl cyclase inhibitors featuring a heteroaryl scaffold.
Daniel Ramsbeck, Mirko Buchholz, Birgit Koch, Livia Böhme, Torsten Hoffmann, Ulrich Heiser

J Med Chem· September 2013

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Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice.
Holger Cynis, Astrid Kehlen, Monique Haegele, Torsten Hoffmann, Ulrich Heiser

Int J Exp Pathol· June 2013

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Glutaminyl cyclases as novel targets for the treatment of septic arthritis.
Annelie Hellvard, Katarzyna Maresz, Stephan Schilling, Sigrid Graubner, Ulrich Heiser

J Infect Dis· March 2013

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Probing secondary glutaminyl cyclase (QC) inhibitor interactions applying an in silico-modeling/site-directed mutagenesis approach: implications for drug development.
Birgit Koch, Mirko Buchholz, Michael Wermann, Ulrich Heiser, Stephan Schilling

Chem Biol Drug Des· December 2012

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The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.
Holger Cynis, Torsten Hoffmann, Daniel Friedrich, Astrid Kehlen, Kathrin Gans, Ulrich Heiser

EMBO Mol Med· September 2011

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Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center.
David Ruiz-Carrillo, Birgit Koch, Christoph Parthier, Michael Wermann, Tresfore Dambe, Ulrich Heiser

Biochemistry· July 2011

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Inhibitors for human glutaminyl cyclase by structure based design and bioisosteric replacement.
Mirko Buchholz, Antje Hamann, Susanne Aust, Wolfgang Brandt, Livia Böhme, Ulrich Heiser

J Med Chem· November 2009

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Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.
Stephan Schilling, Ulrike Zeitschel, Torsten Hoffmann, Ulrich Heiser, Mike Francke

Nat Med· October 2008

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Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ.
Stephan Schilling, Thomas Appl, Torsten Hoffmann, Holger Cynis, Katrin Schulz, Ulrich Heiser

J Neurochem· August 2008

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Novel inhibitor for prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis and details of substrate-recognition mechanism.
Yue Xu, Yoshitaka Nakajima, Kiyoshi Ito, Heng Zheng, Hiroshi Oyama, Ulrich Heiser

J Mol Biol· January 2008

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Neuropeptide Y (NPY) cleaving enzymes: structural and functional homologues of dipeptidyl peptidase 4.
Nadine Frerker, Leona Wagner, Raik Wolf, Ulrich Heiser, Torsten Hoffmann

Peptides· February 2007

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Does human attractin have DP4 activity?
Daniel Friedrich, Torsten Hoffmann, Joachim Bär, Michael Wermann, Susanne Manhart, Ulrich Heiser

Biol Chem· February 2007

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Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells.
Holger Cynis, Stephan Schilling, Mandy Bodnár, Torsten Hoffmann, Ulrich Heiser

Biochim Biophys Acta· October 2006

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Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV.
Michael Engel, Torsten Hoffmann, Susanne Manhart, Ulrich Heiser, Sylvie Chambre

J Mol Biol· January 2006

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The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship.
Mirko Buchholz, Ulrich Heiser, Stephan Schilling, André J Niestroj, Katrin Zunkel

J Med Chem· January 2006

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Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase.
Stephan Schilling, Holger Cynis, Alex von Bohlen, Torsten Hoffmann, Michael Wermann, Ulrich Heiser

Biochemistry· October 2005

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Temperature-dependent behavior of a symmetric long-chain bolaamphiphile with phosphocholine headgroups in water: from hydrogel to nanoparticles.
Karen Köhler, Günter Förster, Anton Hauser, Bodo Dobner, Ulrich F Heiser

J Am Chem Soc· December 2004

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Self-assembly in a bipolar phosphocholine-water system: the formation of nanofibers and hydrogels.
Karen Köhler, Günter Förster, Anton Hauser, Bodo Dobner, Ulrich F Heiser

Angew Chem Int Ed Engl· January 2004

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Acylated hydroxamates as selective and highly potent inhibitors of dipeptidyl peptidase I.
André J Niestroj, Dagmar Schlenzig, Ulrich Heiser, Kerstin Kühn-Wache, Blas Cigic

Adv Exp Med Biol· July 2003

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The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism.
Michael Engel, Torsten Hoffmann, Leona Wagner, Michael Wermann, Ulrich Heiser

Proc Natl Acad Sci U S A· April 2003

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The expression of T-cell surface antigens CTLA-4, CD26, and CD28 is modulated by inhibition of dipeptidylpeptidase IV (DPP IV, CD26) activity in murine stress-induced abortions.
Jens Rüter, Torsten Hoffmann, Ulrich Heiser, Hans Ulrich Demuth, Petra C Arck

Cell Immunol· December 2002

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