Publications by authors named "Dani Brunner"

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Synthesis and biological evaluation of novel hybrids of highly potent and selective α4β2-Nicotinic acetylcholine receptor (nAChR) partial agonists.
Han-Kun Zhang, J Brek Eaton, Allison Fedolak, Hendra Gunosewoyo, Oluseye K Onajole, Dani Brunner

Eur J Med Chem· November 2016

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Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice.
Vadim Alexandrov, Dani Brunner, Liliana B Menalled, Andrea Kudwa, Judy Watson-Johnson

Nat Biotechnol· August 2016

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Synthesis and Behavioral Studies of Chiral Cyclopropanes as Selective α4β2-Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Profile. Part III.
Oluseye K Onajole, Gian Paolo Vallerini, J Brek Eaton, Ronald J Lukas, Dani Brunner

ACS Chem Neurosci· June 2016

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Genetic deletion of transglutaminase 2 does not rescue the phenotypic deficits observed in R6/2 and zQ175 mouse models of Huntington's disease.
Liliana B Menalled, Andrea E Kudwa, Steve Oakeshott, Andrew Farrar, Neil Paterson, Dani Brunner

PLoS One· October 2015

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Reprint of: Highthroughtput analysis of behavior for drug discovery.
Vadim Alexandrov, Dani Brunner, Taleen Hanania, Emer Leahy

Eur J Pharmacol· April 2015

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High-throughput analysis of behavior for drug discovery.
Vadim Alexandrov, Dani Brunner, Taleen Hanania, Emer Leahy

Eur J Pharmacol· March 2015

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Enantiopure Cyclopropane-Bearing Pyridyldiazabicyclo[3.3.0]octanes as Selective α4β2-nAChR Ligands.
Oluseye K Onajole, J Brek Eaton, Ronald J Lukas, Dani Brunner, Lucinda Thiede

ACS Med Chem Lett· November 2014

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Cognitive deficits in transgenic and knock-in HTT mice parallel those in Huntington's disease.
Andrew M Farrar, Carol A Murphy, Neil E Paterson, Stephen Oakeshott, Dansha He, Dani Brunner

J Huntingtons Dis· September 2014

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Scientific rigor and the art of motorcycle maintenance.
Marcus Munafò, Simon Noble, William J Browne, Dani Brunner, Katherine Button

Nat Biotechnol· September 2014

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SAHA enhances synaptic function and plasticity in vitro but has limited brain availability in vivo and does not impact cognition.
Jesse E Hanson, Hank La, Emile Plise, Yung-Hsiang Chen, Xiao Ding, Dani Brunner

PLoS One· April 2014

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The potent and selective α4β2*/α6*-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-like behavior in animal models and a favorable ADME-tox profile.
Li-Fang Yu, J Brek Eaton, Han-Kun Zhang, Emily Sabath, Taleen Hanania, Dani Brunner

Pharmacol Res Perspect· April 2014

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Deficits in a Simple Visual Go/No-go Discrimination Task in Two Mouse Models of Huntington's Disease.
Stephen Oakeshott, Andrew Farrar, Russell Port, Jane Cummins-Sutphen, Jason Berger, Dani Brunner

PLoS Curr· November 2013

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High-Throughput Automated Phenotyping of Two Genetic Mouse Models of Huntington's Disease.
Fuat Balci, Stephen Oakeshott, Jul Lea Shamy, Bassem F El-Khodor, Igor Filippov, Dani Brunner

PLoS Curr· July 2013

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Increased Body Weight of the BAC HD Transgenic Mouse Model of Huntington's Disease Accounts for Some but Not All of the Observed HD-like Motor Deficits.
Andrea E Kudwa, Liliana B Menalled, Stephen Oakeshott, Carol Murphy, Richard Mushlin, Dani Brunner

PLoS Curr· July 2013

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Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175.
Liliana B Menalled, Andrea E Kudwa, Sam Miller, Jon Fitzpatrick, Judy Watson-Johnson, Dani Brunner

PLoS One· June 2013

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Characterization of maleimide-based glycogen synthase kinase-3 (GSK-3) inhibitors as stimulators of steroidogenesis.
Hendra Gunosewoyo, Andrew Midzak, Irina N Gaisina, Emily V Sabath, Allison Fedolak, Dani Brunner

J Med Chem· June 2013

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Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II.
Li-Fang Yu, J Brek Eaton, Allison Fedolak, Han-Kun Zhang, Taleen Hanania, Dani Brunner

J Med Chem· November 2012

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A mixed fixed ratio/progressive ratio procedure reveals an apathy phenotype in the BAC HD and the z_Q175 KI mouse models of Huntington's disease.
Stephen Oakeshott, Russell Port, Jane Cummins-Sutphen, Jason Berger, Judy Watson-Johnson, Dani Brunner

PLoS Curr· April 2012

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Comparative psychology and the grand challenge of drug discovery in psychiatry and neurodegeneration.
Dani Brunner, Fuat Balcı, Elliot A Ludvig

Behav Processes· February 2012

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Effect of the rd1 mutation on motor performance in R6/2 and wild type mice.
Liliana Menalled, Bassem F El-Khodor, Monica Hornberger, Larry Park, David Howland, Dani Brunner

PLoS Curr· February 2012

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Identification of novel α4β2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity.
Li-Fang Yu, Werner Tückmantel, J Brek Eaton, Barbara Caldarone, Allison Fedolak, Dani Brunner

J Med Chem· January 2012

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HD mouse models reveal clear deficits in learning to perform a simple instrumental response.
Stephen Oakeshott, Russell G Port, Jane Cummins-Sutphen, Judy Watson-Johnson, Sylvie Ramboz, Dani Brunner

PLoS Curr· November 2011

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Rapid, computer vision-enabled murine screening system identifies neuropharmacological potential of two new mechanisms.
Steven L Roberds, Igor Filippov, Vadim Alexandrov, Taleen Hanania, Dani Brunner

Front Neurosci· November 2011

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Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington's Disease.
Stephen Oakeshott, Fuat Balci, Igor Filippov, Carol Murphy, Russell Port, Dani Brunner

PLoS Curr· April 2011

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