Publications by authors named "Daniel Gewirth"

Claim this Profile
S
Selective Inhibition of hsp90 Paralogs: Uncovering the Role of Helix 1 in Grp94-Selective Ligand Binding.
Nanette L S Que, Paul M Seidler, Wen J Aw, Gabriela Chiosis, Daniel T Gewirth

Proteins· March 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Selective inhibition of hsp90 paralogs: Uncovering the role of helix 1 in Grp94-selective ligand binding.
Nanette L S Que, Paul M Seidler, Wen J Aw, Gabriela Chiosis, Daniel T Gewirth

bioRxiv· August 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structural transitions modulate the chaperone activities of Grp94.
Yaa S Amankwah, Yasmeen Fleifil, Erin Unruh, Preston Collins, Yi Wang, Daniel T Gewirth

Proc Natl Acad Sci U S A· March 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Second international symposium on the chaperone code, 2023.
Johannes Buchner, Milad J Alasady, Sarah J Backe, Brian S J Blagg, Richard L Carpenter, Daniel T Gewirth

Cell Stress Chaperones· February 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Selective targeting of GARP-LTGFβ axis in the tumor microenvironment augments PD-1 blockade via enhancing CD8 T cell antitumor immunity.
Anqi Li, Yuzhou Chang, No-Joon Song, Xingjun Wu, Dongjun Chung, Daniel T Gewirth

J Immunother Cancer· September 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone.
Pengrong Yan, Hardik J Patel, Sahil Sharma, Adriana Corben, Tai Wang, Daniel T Gewirth

Cell Rep· June 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β.
Alessandra Metelli, Bill X Wu, Brian Riesenberg, Silvia Guglietta, John D Huck, Daniel T Gewirth

Sci Transl Med· January 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90.
John D Huck, Nanette L S Que, Robert M Immormino, Liza Shrestha, Tony Taldone, Daniel T Gewirth

J Biol Chem· November 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structures of Hsp90α and Hsp90β bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity.
John D Huck, Nanette L S Que, Sahil Sharma, Tony Taldone, Gabriela Chiosis, Daniel T Gewirth

Proteins· October 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Chaperome heterogeneity and its implications for cancer study and treatment.
Tai Wang, Anna Rodina, Mark P Dunphy, Adriana Corben, Shanu Modi, Daniel T Gewirth

J Biol Chem· February 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Potential impact of combined inhibition of 3α-oxidoreductases and 5α-reductases on prostate cancer.
Michael V Fiandalo, Daniel T Gewirth, James L Mohler

Asian J Urol· January 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.
Nanette L S Que, Vincent M Crowley, Adam S Duerfeldt, Jinbo Zhao, Caitlin N Kent, Daniel T Gewirth

J Med Chem· April 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Bypassing Drug Resistance Mechanisms of Prostate Cancer with Small Molecules that Target Androgen Receptor-Chromatin Interactions.
Kush Dalal, Meixia Che, Nanette S Que, Aishwariya Sharma, Rendong Yang, Daniel T Gewirth

Mol Cancer Ther· October 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site.
John D Huck, Nanette L Que, Feng Hong, Zihai Li, Daniel T Gewirth

Cell Rep· September 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Exploring the Functional Complementation between Grp94 and Hsp90.
Kevin A Maharaj, Nanette L S Que, Feng Hong, John D Huck, Sabrina K Gill, Daniel T Gewirth

PLoS One· June 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94.
Ephraim A Ansa-Addo, Jessica Thaxton, Feng Hong, Bill X Wu, Yongliang Zhang, Daniel T Gewirth

Curr Top Med Chem· February 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Paralog Specific Hsp90 Inhibitors - A Brief History and a Bright Future.
Daniel T Gewirth

Curr Top Med Chem· February 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94.
Hardik J Patel, Pallav D Patel, Stefan O Ochiana, Pengrong Yan, Weilin Sun, Daniel T Gewirth

J Med Chem· May 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Characterization of the Grp94/OS-9 chaperone-lectin complex.
Paul M Seidler, Stephen A Shinsky, Feng Hong, Zihai Li, Michael S Cosgrove, Daniel T Gewirth

J Mol Biol· October 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.
Pallav D Patel, Pengrong Yan, Paul M Seidler, Hardik J Patel, Weilin Sun, Daniel T Gewirth

Nat Chem Biol· November 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series.
Tony Taldone, Pallav D Patel, Maulik Patel, Hardik J Patel, Christopher E Evans, Daniel Gewirth

J Med Chem· September 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
Î
α7 helix region of αI domain is crucial for integrin binding to endoplasmic reticulum chaperone gp96: a potential therapeutic target for cancer metastasis.
Feng Hong, Bei Liu, Gabriela Chiosis, Daniel T Gewirth, Zihai Li

J Biol Chem· June 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The molecular chaperone gp96/GRP94 interacts with Toll-like receptors and integrins via its C-terminal hydrophobic domain.
Shuang Wu, Feng Hong, Daniel Gewirth, Beichu Guo, Bei Liu

J Biol Chem· February 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design.
Robert M Immormino, Louis E Metzger, Patrick N Reardon, D Eric Dollins, Brian S J Blagg, Daniel T Gewirth

J Mol Biol· May 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structures of GRP94-nucleotide complexes reveal mechanistic differences between the hsp90 chaperones.
D Eric Dollins, Joshua J Warren, Robert M Immormino, Daniel T Gewirth

Mol Cell· October 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis