Publications by authors named "Daniel Wyss"

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WRN structural flexibility showcased through fragment-based lead discovery of inhibitors.
Rachel L Palte, Mihir Mandal, Justyna Sikorska, Artjohn B Villafania, Meredith M Rickard, Daniel F Wyss

Nat Commun· January 2026

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Recent developments in understanding RIG-I's activation and oligomerization.
Justyna Sikorska, Daniel F Wyss

Sci Prog· August 2024

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Characterization of RNA driven structural changes in full length RIG-I leading to its agonism or antagonism.
Justyna Sikorska, Yan Hou, Paul Chiurazzi, Tony Siu, Gretchen A Baltus, Daniel F Wyss

Nucleic Acids Res· September 2023

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Integrated CRISPR screening and drug profiling identifies combination opportunities for EGFR, ALK, and BRAF/MEK inhibitors.
Ralph Tiedt, Frederick J King, Christelle Stamm, Matthew J Niederst, Scott Delach, Daniel Wyss

Cell Rep· April 2023

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Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
Mihirbaran Mandal, Li Xiao, Weidong Pan, Giovanna Scapin, Guoqing Li, Daniel F Wyss

J Med Chem· December 2022

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Irrigated Crop Types Mapping in Tashkent Province of Uzbekistan with Remote Sensing-Based Classification Methods.
Elbek Erdanaev, Martin Kappas, Daniel Wyss

Sensors (Basel)· July 2022

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Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.
Wonsuk Chang, Michael D Altman, Charles A Lesburg, Samanthi A Perera, Jennifer A Piesvaux, Daniel F Wyss

J Med Chem· April 2022

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Assessment of Climate Change and Human Activities on Vegetation Development in Northeast China.
Lin Xue, Martin Kappas, Daniel Wyss, Chaoqun Wang, Birgitta Putzenlechner

Sensors (Basel)· March 2022

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An orally available non-nucleotide STING agonist with antitumor activity.
Bo-Sheng Pan, Samanthi A Perera, Jennifer A Piesvaux, Jeremy P Presland, Gottfried K Schroeder, Daniel F Wyss

Science· August 2020

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NMR Binding and Functional Assays for Detecting Inhibitors of S. aureus MnaA.
Yan Hou, Todd Mayhood, Payal Sheth, Christopher M Tan, Marc Labroli, Daniel F Wyss

J Biomol Screen· July 2016

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High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response.
Hui Gao, Joshua M Korn, Stéphane Ferretti, John E Monahan, Youzhen Wang, Daniel Wyss

Nat Med· November 2015

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NMR screening in fragment-based drug design: a practical guide.
Hai-Young Kim, Daniel F Wyss

Methods Mol Biol· September 2015

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The identification of novel 5'-amino gemcitabine analogs as potent RRM1 inhibitors.
Marc A Labroli, Michael P Dwyer, Ruichao Shen, Janeta Popovici-Muller, Qinglin Pu, Daniel Wyss

Bioorg Med Chem· April 2014

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Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors.
Daniel F Wyss, Yu-Sen Wang, Hugh L Eaton, Corey Strickland, Johannes H Voigt

Top Curr Chem· August 2012

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The ion channel transient receptor potential melastatin-2 does not play a role in inflammatory mouse models of chronic obstructive pulmonary diseases.
Liz Hardaker, Parmjit Bahra, Benjamin Cochin de Billy, Mark Freeman, Natalia Kupfer, Daniel Wyss

Respir Res· April 2012

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Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors.
Xiaohua Huang, Gerald W Shipps, Cliff C Cheng, Peter Spacciapoli, Xingmin Zhang, Daniel F Wyss

ACS Med Chem Lett· August 2011

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Effective progression of nuclear magnetic resonance-detected fragment hits.
Hugh L Eaton, Daniel F Wyss

Methods Enzymol· June 2011

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Noninvasive assessment of bleomycin-induced lung injury and the effects of short-term glucocorticosteroid treatment in rats using MRI.
Anna L Babin, Catherine Cannet, Christelle Gérard, Daniel Wyss, Clive P Page

J Magn Reson Imaging· March 2011

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Pyridine Carboxamides: Potent Palm Site Inhibitors of HCV NS5B Polymerase.
Cliff C Cheng, Xiaohua Huang, Gerald W Shipps, Yu-Sen Wang, Daniel F Wyss

ACS Med Chem Lett· December 2010

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Pharmacological characterisation of anti-inflammatory compounds in acute and chronic mouse models of cigarette smoke-induced inflammation.
Wing-Yan Heidi Wan, Abigail Morris, Gillian Kinnear, William Pearce, Joanie Mok, Daniel Wyss

Respir Res· September 2010

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The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist.
François Baur, David Beattie, David Beer, David Bentley, Michelle Bradley, Daniel Wyss

J Med Chem· May 2010

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Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validation.
Zhaoning Zhu, Zhong-Yue Sun, Yuanzan Ye, Johannes Voigt, Corey Strickland, Daniel F Wyss

J Med Chem· February 2010

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Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors.
Yu-Sen Wang, Corey Strickland, Johannes H Voigt, Matthew E Kennedy, Brian M Beyer, Daniel F Wyss

J Med Chem· February 2010

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Comparison of cigarette smoke-induced acute inflammation in multiple strains of mice and the effect of a matrix metalloproteinase inhibitor on these responses.
Abigail Morris, Gillian Kinnear, Wing-Yan Heidi Wan, Daniel Wyss, Parmjit Bahra

J Pharmacol Exp Ther· December 2008

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Characterization of autocatalytic conversion of precursor BACE1 by heteronuclear NMR spectroscopy.
Yu-Sen Wang, Brian M Beyer, Mary M Senior, Daniel F Wyss

Biochemistry· December 2005

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