Publications by authors named "Darcie Miller"

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Subtle changes in ligand-receptor interactions dramatically alter transcriptional outcomes of pregnane X receptor modulators.
Andrew D Huber, Efren Garcia-Maldonado, Wenwei Lin, Shyaron Poudel, Jing Wu, Darcie J Miller

Structure· January 2026

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Design and synthesis of novel 4-aryl-2-benzoyl-imidazoles as colchicine binding site inhibitors.
Najah Albadari, Yang Xie, Qinghui Wang, Darcie J Miller, Judith Quadrozzi Gruntz, Duane D Miller

Eur J Med Chem· November 2025

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Mechanisms of assembly and function of the Hsp70-Hsp40 chaperone machinery.
Yajun Jiang, Ziad Ibrahim, Youlin Xia, Mary Clay, Alexander Myasnikov, Darcie Miller

Mol Cell· November 2025

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Decoding the selective chemical modulation of CYP3A4.
Jingheng Wang, Stanley Nithianantham, Sergio C Chai, Young-Hwan Jung, Lei Yang, Darcie J Miller

Nat Commun· April 2025

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{Rmerg, Rmeas, Rpim, CC1/2} for Crystal Diffraction Data Quality Evaluation.
Zheng-Qing Fu, Brian V Geisbrecht, Samuel Bouyain, Fred Dyda, John Chrzas, Darcie J Miller

bioRxiv· February 2025

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PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network.
Andrew D Huber, Wenwei Lin, Shyaron Poudel, Darcie J Miller, Taosheng Chen

Structure· December 2024

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EMhub: a web platform for data management and on-the-fly processing in scientific facilities.
Jose M de la Rosa-Trevin, Grigory Sharov, Stefan Fleischmann, Dustin Morado, John C Bollinger, Darcie J Miller

Acta Crystallogr D Struct Biol· November 2024

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Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases.
Daniel C Scott, Sagar Chittori, Nicholas Purser, Moeko T King, Samuel A Maiwald, Darcie J Miller

Nat Commun· November 2024

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Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2.
Daniel C Scott, Suresh Dharuman, Elizabeth Griffith, Sergio C Chai, Jarrid Ronnebaum, Darcie J Miller

Nat Commun· October 2024

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Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR.
Efren Garcia-Maldonado, Andrew D Huber, Sergio C Chai, Stanley Nithianantham, Yongtao Li, Darcie J Miller

Nat Commun· May 2024

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A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR.
Andrew D Huber, Shyaron Poudel, Jing Wu, Darcie J Miller, Wenwei Lin

Nucleic Acids Res· February 2024

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Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines.
Gisele Nishiguchi, Lauren G Mascibroda, Sarah M Young, Elizabeth A Caine, Sherif Abdelhamed, Darcie J Miller, Shondra M Pruett-Miller

Nat Commun· January 2024

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Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand.
Andrew D Huber, Shyaron Poudel, Yongtao Li, Wenwei Lin, Jing Wu, Darcie J Miller

Structure· December 2023

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Human IFT-A complex structures provide molecular insights into ciliary transport.
Meiqin Jiang, Vivek Reddy Palicharla, Darcie Miller, Sun-Hee Hwang, Hanwen Zhu

Cell Res· April 2023

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Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein.
Wenwei Lin, Andrew D Huber, Shyaron Poudel, Yongtao Li, Jayaraman Seetharaman, Darcie J Miller

Proc Natl Acad Sci U S A· March 2023

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Biochemical characterization of the first step in sulfonolipid biosynthesis in Alistipes finegoldii.
Christopher D Radka, Darcie J Miller, Matthew W Frank, Charles O Rock

J Biol Chem· August 2022

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Imatinib can act as an Allosteric Activator of Abl Kinase.
Tao Xie, Tamjeed Saleh, Paolo Rossi, Darcie Miller, Charalampos G Kalodimos

J Mol Biol· January 2022

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Biophysical analysis of the Mycobacteria tuberculosis peptide binding protein DppA reveals a stringent peptide binding pocket.
Dinesh M Fernando, Clifford T Gee, Elizabeth C Griffith, Christopher J Meyer, Laura A Wilt, Darcie J Miller

Tuberculosis (Edinb)· January 2022

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Mechanism for the activation of the anaplastic lymphoma kinase receptor.
Andrey V Reshetnyak, Paolo Rossi, Alexander G Myasnikov, Munia Sowaileh, Jyotidarsini Mohanty, Darcie J Miller

Nature· December 2021

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Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5.
Jingheng Wang, Cameron D Buchman, Jayaraman Seetharaman, Darcie J Miller, Andrew D Huber

J Am Chem Soc· November 2021

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The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma.
Min Pan, William C Wright, Richard H Chapple, Asif Zubair, Manbir Sandhu, Darcie Miller, Shondra M Pruett-Miller

Nat Commun· November 2021

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Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases.
Seung Wook Yang, Xin Huang, Wenwei Lin, Jaeki Min, Darcie J Miller

Nat Commun· October 2020

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Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.
Sajjan Koirala, Jonathon Klein, Yumei Zheng, Nicole O Glenn, Travis Eisemann, Darcie J Miller

Cell Rep· July 2020

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The genome of a Bacteroidetes inhabitant of the human gut encodes a structurally distinct enoyl-acyl carrier protein reductase (FabI).
Christopher D Radka, Matthew W Frank, Jiangwei Yao, Jayaraman Seetharaman, Darcie J Miller

J Biol Chem· May 2020

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Ureadepsipeptides as ClpP Activators.
Elizabeth C Griffith, Ying Zhao, Aman P Singh, Brian P Conlon, Rajendra Tangallapally, Darcie J Miller

ACS Infect Dis· November 2019

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