Publications by authors named "David Darr"

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Minibeam radiation therapy enhanced tumor delivery of PEGylated liposomal doxorubicin in a triple-negative breast cancer mouse model.
Lauren S L Price, Judith N Rivera, Andrew J Madden, Leah B Herity, Joseph A Piscitelli, David Darr

Ther Adv Med Oncol· October 2021

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Identification of harmine and β-carboline analogs from a high-throughput screen of an approved drug collection; profiling as differential inhibitors of DYRK1A and monoamine oxidase A and for in vitro and in vivo anti-cancer studies.
Michael Tarpley, Helen O Oladapo, Dillon Strepay, Thomas B Caligan, Lhoucine Chdid, David B Darr

Eur J Pharm Sci· July 2021

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Content and Performance of the MiniMUGA Genotyping Array: A New Tool To Improve Rigor and Reproducibility in Mouse Research.
John Sebastian Sigmon, Matthew W Blanchard, Ralph S Baric, Timothy A Bell, Jennifer Brennan, David B Darr

Genetics· December 2020

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Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy.
Aadra P Bhatt, Samuel J Pellock, Kristen A Biernat, William G Walton, Bret D Wallace, David B Darr

Proc Natl Acad Sci U S A· March 2020

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The MMTV-Wnt1 murine model produces two phenotypically distinct subtypes of mammary tumors with unique therapeutic responses to an EGFR inhibitor.
Adam D Pfefferle, David B Darr, Benjamin C Calhoun, Kevin R Mott, Jeffrey M Rosen

Dis Model Mech· July 2019

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A mouse model featuring tissue-specific deletion of p53 and Brca1 gives rise to mammary tumors with genomic and transcriptomic similarities to human basal-like breast cancer.
Daniel P Hollern, Cristina M Contreras, Stephanie Dance-Barnes, Grace O Silva, Adam D Pfefferle, David B Darr

Breast Cancer Res Treat· February 2019

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A nanoparticle-incorporated STING activator enhances antitumor immunity in PD-L1-insensitive models of triple-negative breast cancer.
Ning Cheng, Rebekah Watkins-Schulz, Robert D Junkins, Clément N David, Brandon M Johnson, David B Darr

JCI Insight· November 2018

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Identification of Jun loss promotes resistance to histone deacetylase inhibitor entinostat through Myc signaling in luminal breast cancer.
Maki Tanioka, Kevin R Mott, Daniel P Hollern, Cheng Fan, David B Darr

Genome Med· November 2018

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Competitive Kinase Enrichment Proteomics Reveals that Abemaciclib Inhibits GSK3β and Activates WNT Signaling.
Emily M Cousins, Dennis Goldfarb, Feng Yan, Jose Roques, David Darr

Mol Cancer Res· February 2018

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New Mechanisms of Resistance to MEK Inhibitors in Melanoma Revealed by Intravital Imaging.
Hailey E Brighton, Steven P Angus, Tao Bo, Jose Roques, Alicia C Tagliatela, David B Darr

Cancer Res· January 2018

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Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.
Helen O Oladapo, Michael Tarpley, Scott J Sauer, Kezia A Addo, Shalonda M Ingram, David B Darr

Cancer Lett· December 2017

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A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma.
Clemens Krepler, Katrin Sproesser, Patricia Brafford, Marilda Beqiri, Bradley Garman, David Darr

Cell Rep· November 2017

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Differential response to exercise in claudin-low breast cancer.
Oliver K Glass, Michelle Bowie, Julie Fuller, David Darr, Jerry Usary

Oncotarget· November 2017

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Preclinical development of G1T38: A novel, potent and selective inhibitor of cyclin dependent kinases 4/6 for use as an oral antineoplastic in patients with CDK4/6 sensitive tumors.
John E Bisi, Jessica A Sorrentino, Jamie L Jordan, David D Darr, Patrick J Roberts

Oncotarget· June 2017

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A Fluorescent Hsp90 Probe Demonstrates the Unique Association between Extracellular Hsp90 and Malignancy in Vivo.
Lauren B Crowe, Philip F Hughes, David A Alcorta, Takuya Osada, Aaron P Smith, David Darr

ACS Chem Biol· April 2017

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Enhancer Remodeling during Adaptive Bypass to MEK Inhibition Is Attenuated by Pharmacologic Targeting of the P-TEFb Complex.
Jon S Zawistowski, Samantha M Bevill, Daniel R Goulet, Timothy J Stuhlmiller, Adriana S Beltran, David B Darr

Cancer Discov· March 2017

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Docetaxel-Loaded PLGA Nanoparticles Improve Efficacy in Taxane-Resistant Triple-Negative Breast Cancer.
Charles J Bowerman, James D Byrne, Kevin S Chu, Allison N Schorzman, Amanda W Keeler, David B Darr

Nano Lett· January 2017

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A high capacity polymeric micelle of paclitaxel: Implication of high dose drug therapy to safety and in vivo anti-cancer activity.
Zhijian He, Xiaomeng Wan, Anita Schulz, Herdis Bludau, Marina A Dobrovolskaia, David B Darr

Biomaterials· September 2016

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Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer.
Yazan Alwarawrah, Philip Hughes, David Loiselle, David A Carlson, David B Darr

Cell Chem Biol· June 2016

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Weight loss reduces basal-like breast cancer through kinome reprogramming.
Yuanyuan Qin, Sneha Sundaram, Luma Essaid, Xin Chen, Samantha M Miller, David B Darr

Cancer Cell Int· April 2016

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cMET inhibitor crizotinib impairs angiogenesis and reduces tumor burden in the C3(1)-Tag model of basal-like breast cancer.
Alyssa J Cozzo, Sneha Sundaram, Ottavia Zattra, Yuanyuan Qin, Alex J Freemerman, David B Darr

Springerplus· April 2016

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Overview of Genetically Engineered Mouse Models of Distinct Breast Cancer Subtypes.
Jerry Usary, David Brian Darr, Adam D Pfefferle, Charles M Perou

Curr Protoc Pharmacol· March 2016

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Poly(2-oxazoline) based micelles with high capacity for 3rd generation taxoids: preparation, in vitro and in vivo evaluation.
Zhijian He, Anita Schulz, Xiaomeng Wan, Joshua Seitz, Herdis Bludau, David B Darr

J Control Release· June 2015

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IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma.
Craig C Carson, Stergios J Moschos, Sharon N Edmiston, David B Darr, Nana Nikolaishvili-Feinberg

Clin Cancer Res· May 2015

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Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA-Wild-Type Triple-Negative Breast Cancer.
Olga Karginova, Marni B Siegel, Amanda E D Van Swearingen, Allison M Deal, Barbara Adamo, David Darr

Mol Cancer Ther· April 2015

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