Publications by authors named "David Leys"

Claim this Profile
S
Structure and Mechanism of PhdC, a Prenylated-Flavin Maturase.
Dominic R Whittall, Henry G Box, Karl A P Payne, Stephen A Marshall, David Leys

Proteins· December 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
F
Fragment-Based Development of Small Molecule Inhibitors Targeting Cholesterol Metabolism.
Madeline E Kavanagh, Kirsty J McLean, Sophie H Gilbert, Cecilia N Amadi, Matthew Snee, David Leys

J Med Chem· July 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Expression and purification of Mycobacterium tuberculosis F-dependent glucose-6-phosphate dehydrogenase enzyme using Escherichia coli.
Adewale Victor Aderemi, Matthew Snee, Richard B Tunnicliffe, Marina Golovanova, Kathleen M Cain, David Leys

Protein Expr Purif· April 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Engineered enzymes for enantioselective nucleophilic aromatic substitutions.
Thomas M Lister, George W Roberts, Euan J Hossack, Fei Zhao, Ashleigh J Burke, David Leys

Nature· March 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
SignatureFinder enables sequence mining to identify cobalamin-dependent photoreceptor proteins.
Yuqi Yu, Laura N Jeffreys, Harshwardhan Poddar, Adam Hill, Linus Johannissen, David Leys

FEBS J· February 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
F
Fragment-based development of small molecule inhibitors targeting cholesterol metabolism.
Madeline E Kavanagh, Kirsty J McLean, Sophie H Gilbert, Cecilia Amadi, Matthew Snee, David Leys

bioRxiv· December 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Methods to study prFMN-UbiD mediated (de)carboxylation.
Dominic R Whittall, David Leys

Methods Enzymol· November 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Photocobilins integrate B and bilin photochemistry for enzyme control.
Shaowei Zhang, Laura N Jeffreys, Harshwardhan Poddar, Yuqi Yu, Chuanyang Liu, David Leys

Nat Commun· March 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The prFMNH-binding chaperone LpdD assists UbiD decarboxylase activation.
Deepankar Gahloth, Karl Fisher, Stephen Marshall, David Leys

J Biol Chem· February 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Efficient NADPH-dependent dehalogenation afforded by a self-sufficient reductive dehalogenase.
Karl Fisher, Tom Halliwell, Karl A P Payne, Gabriel Ragala, Sam Hay, David Leys

J Biol Chem· September 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Redox driven B-ligand switch drives CarH photoresponse.
Harshwardhan Poddar, Ronald Rios-Santacruz, Derren J Heyes, Muralidharan Shanmugam, Adam Brookfield, David Leys

Nat Commun· August 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Prenylated flavins: structures and mechanisms.
Samuel Bloor, Iaroslav Michurin, Gabriel R Titchiner, David Leys

FEBS J· May 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis.
Mona M Katariya, Matthew Snee, Richard B Tunnicliffe, Madeline E Kavanagh, Helena I M Boshoff, David Leys

Chemistry· May 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A Vitamin B -Photocatalysed Approach to Methionine Analogues.
Oliver J Knowles, Linus O Johannissen, Giacomo E M Crisenza, Sam Hay, David Leys

Angew Chem Int Ed Engl· December 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A Vitamin B-Photocatalysed Approach to Methionine Analogues.
Oliver J Knowles, Linus O Johannissen, Giacomo E M Crisenza, Sam Hay, David Leys

Angew Chem Weinheim Bergstr Ger· December 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structural insights into UbiD reversible decarboxylation.
George W Roberts, David Leys

Curr Opin Struct Biol· August 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
Heterologous production and biophysical characterization of catabolic Nitratireductor pacificus pht-3B reductive dehalogenase.
Tom Halliwell, Karl Fisher, Stephen E J Rigby, David Leys

Methods Enzymol· May 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Enzymatic -Allylation of Primary and Secondary Amines Using Renewable Cinnamic Acids Enabled by Bacterial Reductive Aminases.
Godwin A Aleku, Gabriel R Titchiner, George W Roberts, Sasha R Derrington, James R Marshall, David Leys

ACS Sustain Chem Eng· May 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structural and biochemical characterization of the prenylated flavin mononucleotide-dependent indole-3-carboxylic acid decarboxylase.
Deepankar Gahloth, Karl Fisher, Karl A P Payne, Matthew Cliff, Colin Levy, David Leys

J Biol Chem· April 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A guide to time-resolved structural analysis of light-activated proteins.
Harshwardhan Poddar, Derren J Heyes, Giorgio Schirò, Martin Weik, David Leys

FEBS J· February 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen).
Martyn Frederickson, Irwin R Selvam, Dimitrios Evangelopoulos, Kirsty J McLean, Mona M Katariya, David Leys

Eur J Med Chem· February 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Directed evolution of prenylated FMN-dependent Fdc supports efficient in vivo isobutene production.
Annica Saaret, Benoît Villiers, François Stricher, Macha Anissimova, Mélodie Cadillon, David Leys

Nat Commun· September 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
U
UbiD domain dynamics underpins aromatic decarboxylation.
Stephen A Marshall, Karl A P Payne, Karl Fisher, Gabriel R Titchiner, Colin Levy, David Leys

Nat Commun· August 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The In Vitro Production of prFMN for Reconstitution of UbiD Enzymes.
Stephen A Marshall, Karl Fisher, David Leys

Methods Mol Biol· June 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure and Mechanism of PA0254/HudA, a prFMN-Dependent Pyrrole-2-carboxylic Acid Decarboxylase Linked to Virulence.
Karl A P Payne, Stephen A Marshall, Karl Fisher, Stephen E J Rigby, Matthew J Cliff, David Leys

ACS Catal· March 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis