Publications by authors named "David Lomas"

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The mechanism of pathogenic α-antitrypsin aggregation in the human liver.
Ibrahim Aldobiyan, Emma L K Elliston, Narinder Heyer-Chauhan, Stefan T Arold, Lingyun Zhao, David A Lomas

Proc Natl Acad Sci U S A· November 2025

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Alpha-1 antitrypsin deficiency and granulomatosis with polyangiitis: a systematic review and meta-analysis.
Reem Alluhibi, Shashank Baradwaaj, Nina Heyer-Chauhan, Aileen Marshall, David A Lomas

Eur Respir Rev· October 2025

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A cure for alpha-1? Novel therapeutics in alpha-1 antitrypsin deficiency.
Reem Alluhibi, Aileen Marshall, David A Lomas, John R Hurst

Eur Respir J· September 2025

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Susceptibility of alpha-1 antitrypsin deficiency variants to polymer-blocking therapy.
Riccardo Ronzoni, Ibrahim Aldobiyan, Elena Miranda, Narinder Heyer-Chauhan, Emma Lk Elliston, David A Lomas

JCI Insight· August 2025

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Assessing inflammatory protein biomarkers in COPD subjects with and without alpha-1 antitrypsin deficiency.
Matthew Moll, Brian D Hobbs, Katherine A Pratte, Chengyue Zhang, Auyon J Ghosh, David A Lomas

Respir Res· July 2025

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Alpha-1 Antitrypsin Deficiency-Associated panniculitis: A survey of lived experience.
Jaiden Townsend, Reem Alluhibi, Nicky Lynch, Richard Woolf, Aileen Marshall, David A Lomas

PLoS One· June 2025

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Top-Down Ion Mobility Mass Spectrometry Reveals a Disease Associated Conformational Ensemble of Alpha-1-antitrypsin.
Sarah Vickers, Ibrahim Aldobiyan, Sarah M Lowen, James A Irving, David A Lomas

J Am Chem Soc· May 2025

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High-resolution characterization of ex vivo AAT polymers by solution-state NMR spectroscopy.
Sarah M Lowen, Christopher A Waudby, Alistair M Jagger, Ibrahim Aldobiyan, Mattia Laffranchi, David A Lomas

Sci Adv· May 2025

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Identification of an exosite at the neutrophil elastase/alpha-1-antitrypsin interface.
Roberto Gangemi, Mattia Bignotti, Andrea Denardo, Claudia N Pearce, Riccardo Ronzoni, David A Lomas

FEBS J· April 2025

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Reduction of Z alpha-1 antitrypsin polymers in human iPSC-hepatocytes and mice by LRRK2 inhibitors.
Deniz Kent, Soon Seng Ng, Adam M Syanda, Payam Khoshkenar, Riccardo Ronzoni, David A Lomas

Hepatology· March 2025

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Assessing Inflammatory Protein Biomarkers in COPD Subjects with and without Alpha-1 Antitrypsin Deficiency.
Matthew Moll, Brian D Hobbs, Katherine A Pratte, Chengyue Zhang, Auyon J Ghosh, David A Lomas

medRxiv· January 2025

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Fibrosis, biomarkers and liver biopsy in AAT deficiency and relation to liver Z protein polymer accumulation.
Anandini Suri, Zidong Zhang, Brent Neuschwander-Tetri, David A Lomas, Nina Heyer-Chauhan

Liver Int· December 2024

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A novel pathological mutant reveals the role of torsional flexibility in the serpin breach in adoption of an aggregation-prone intermediate.
Kamila Kamuda, Riccardo Ronzoni, Avik Majumdar, Fiona H X Guan, James A Irving, David A Lomas

FEBS J· July 2024

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Biomarkers Associated With Future Severe Liver Disease in Children With Alpha-1-Antitrypsin Deficiency.
Jeffrey H Teckman, Paula Buchanan, Keith Steven Blomenkamp, Nina Heyer-Chauhan, Keith Burling, David A Lomas

Gastro Hep Adv· April 2024

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Native and Ion Mobility Mass Spectrometry Characterization of Alpha 1 Antitrypsin Variants and Oligomers.
Sarah Vickers, James Irving, David A Lomas, Konstantinos Thalassinos

Methods Mol Biol· December 2023

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The under-appreciated world of the serpin family of serine proteinase inhibitors.
Marie-Christine Bouton, Margarethe Geiger, William P Sheffield, James A Irving, David A Lomas

EMBO Mol Med· June 2023

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X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study.
Lystra P Hayden, Brian D Hobbs, Robert Busch, Michael H Cho, Ming Liu, David A Lomas

Respir Res· February 2023

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Keratin 8 is a scaffolding and regulatory protein of ERAD complexes.
Iwona Maria Pranke, Benoit Chevalier, Aiswarya Premchandar, Nesrine Baatallah, Kamil F Tomaszewski, David A Lomas

Cell Mol Life Sci· September 2022

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Correction to: Single-Inhaler Triple Therapy and Health-Related Quality of Life in COPD: The IMPACT Study.
Maggie Tabberer, C Elaine Jones, Sally Kilbride, David M G Halpin, David A Lomas

Adv Ther· March 2022

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Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease.
Auyon J Ghosh, Brian D Hobbs, Matthew Moll, Aabida Saferali, Adel Boueiz, David Lomas

Am J Respir Crit Care Med· February 2022

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Multiple stakeholder perspectives of factors influencing differential outcomes for ethnic minority students on health and social care placements: a qualitative exploration.
Julie Nightingale, Jackie Parkin, Pete Nelson, Shirley Masterson-Ng, Jacqui Brewster, David Lomas

BMC Med Educ· January 2022

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Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease.
Preeti Lakshman Kumar, Ava C Wilson, Alison Rocco, Michael H Cho, Emily Wan, David A Lomas

J Cachexia Sarcopenia Muscle· December 2021

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A single blood eosinophil count measurement is as good as two for prediction of ICS treatment response in the IMPACT trial.
Mona Bafadhel, Neil Barnes, Stephen C Bourke, Chris Compton, Gerard J Criner, David A Lomas

Eur Respir J· September 2021

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Limitations to Contingency Measures: Reflections from COVID-19 Surges in the UK.
Caitlin Gordon, Sarah Yardley, David A Lomas, Sarah J L Edwards

Am J Bioeth· August 2021

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Quantitative F-fluorodeoxyglucose positron emission tomography/computed tomography to assess pulmonary inflammation in COPD.
Laurence Vass, Marie Fisk, Joseph Cheriyan, Divya Mohan, Julia Forman, David A Lomas

ERJ Open Res· July 2021

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