Publications by authors named "David Tattersall"

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Discovery and optimization of pyrrolopyrimidines as highly potent, selective and brain-penetrant LRRK2 inhibitors.
Jeffrey M Axten, Xiao Ding, Luigi Piero Stasi, Baowei Zhao, Yingxia Sang, F David Tattersall

RSC Med Chem· November 2025

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5-Substituted-N-pyridazinylbenzamides as potent and selective LRRK2 inhibitors: Improved brain unbound fraction enables efficacy.
Xiao Ding, Luigi Piero Stasi, Xuedong Dai, Kai Long, Cheng Peng, F David Tattersall

Bioorg Med Chem Lett· January 2019

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Discovery of 4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potent, selective and orally bioavailable LRRK2 inhibitors.
Xiao Ding, Luigi Piero Stasi, Ming-Hsun Ho, Baowei Zhao, Hailong Wang, F David Tattersall

Bioorg Med Chem Lett· May 2018

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An Alternative Cuprizone-Induced Demyelination and Remyelination Mouse Model.
Wei Zhen, Ailian Liu, Jiaqi Lu, Wandong Zhang, David Tattersall

ASN Neuro· December 2017

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Identification and characterization of two families of F420 H2-dependent reductases from Mycobacteria that catalyse aflatoxin degradation.
Matthew C Taylor, Colin J Jackson, David B Tattersall, Nigel French, Thomas S Peat

Mol Microbiol· November 2010

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In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist.
John R Atack, Karen A Maubach, Keith A Wafford, Desmond O'Connor, A David Rodrigues, F David Tattersall

J Pharmacol Exp Ther· November 2009

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Cloning, expression, purification, crystallization and preliminary X-ray studies of a pyridoxine 5'-phosphate oxidase from Mycobacterium smegmatis.
Colin J Jackson, Matthew C Taylor, David B Tattersall, Nigel G French, Paul D Carr

Acta Crystallogr Sect F Struct Biol Cryst Commun· May 2008

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Metabolon formation in dhurrin biosynthesis.
Kirsten Annette Nielsen, David B Tattersall, Patrik Raymond Jones, Birger Lindberg Møller

Phytochemistry· January 2008

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Novel lactam NK1 antagonists with anti-emetic activity.
Gregory J Hollingworth, Emma J Carlson, José L Castro, Gary G Chicchi, Natalie Clark, F David Tattersall

Bioorg Med Chem Lett· March 2006

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Imidazo[1,2-a]pyrimidines as functionally selective GABA(A) ligands.
Wesley P Blackaby, John R Atack, Frances Bromidge, José L Castro, Simon C Goodacre, David F D Tattersall

Bioorg Med Chem Lett· March 2006

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Detection of gender differences in rat lens proteins using 2-D-DIGE.
Paul C Guest, Heather A Skynner, Kamran Salim, F David Tattersall, Michael R Knowles

Proteomics· January 2006

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The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety.
Chris S Busse, Jesse Brodkin, David Tattersall, Jeffery J Anderson, Noelle Warren

Neuropsychopharmacology· November 2004

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Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers.
Francine Sternfeld, Robert W Carling, Richard A Jelley, Tamara Ladduwahetty, Kevin J Merchant, F David Tattersall

J Med Chem· April 2004

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The in vitro substrate regiospecificity of recombinant UGT85B1, the cyanohydrin glucosyltransferase from Sorghum bicolor.
Karina Sinding Hansen, Charlotte Kristensen, David Bruce Tattersall, Patrik Raymond Jones, Carl Erik Olsen

Phytochemistry· September 2003

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Brain penetration of aprepitant, a substance P receptor antagonist, in ferrets.
Su-Er W Huskey, Brian J Dean, Ray Bakhtiar, Rosa I Sanchez, F David Tattersall

Drug Metab Dispos· June 2003

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Spirocyclic NK(1) antagonists II: [4.5]-spiroethers.
Brian J Williams, Margaret A Cascieri, Gary G Chicchi, Timothy Harrison, Andrew P Owens, David F Tattersall

Bioorg Med Chem Lett· October 2002

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