Publications by authors named "Dean Hickman"

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Population pharmacokinetics of TBAJ-587 and its main metabolites-Evaluation of different loading dose strategies and early dose selection.
Albin A M Leding, Paul Bruinenberg, Almari Conradie, Jerry Nedelman, Antonio Lombardi, Dean Hickman

Br J Clin Pharmacol· November 2025

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A next-generation HDAC6 inhibitor for amyotrophic lateral sclerosis and frontotemporal dementia.
Rebecca E James, Michael Bekier, Pin-Tsun Justin Lee, Frederick A Schroeder, Lauren T Evans, Dean Hickman

Brain· October 2025

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Pharmacokinetics, tolerability, and safety of TBI-223, a novel oxazolidinone, in healthy participants.
Antonio Lombardi, Fran Pappas, Paul Bruinenberg, Jerry Nedelman, Rajneesh Taneja, Dean Hickman

Antimicrob Agents Chemother· April 2025

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Personalized Vascularized Models of Breast Cancer Desmoplasia Reveal Biomechanical Determinants of Drug Delivery to the Tumor.
Giovanni S Offeddu, Elena Cambria, Sarah E Shelton, Kristina Haase, Zhengpeng Wan, Dean Hickman

Adv Sci (Weinh)· October 2024

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Pharmacokinetics and safety of TBAJ-876, a novel antimycobacterial diarylquinoline, in healthy subjects.
Antonio Lombardi, Fran Pappas, Jerry Nedelman, Dean Hickman, Sarah Jaw-Tsai

Antimicrob Agents Chemother· October 2024

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Engineered human blood-brain barrier microfluidic model for vascular permeability analyses.
Cynthia Hajal, Giovanni S Offeddu, Yoojin Shin, Shun Zhang, Olga Morozova, Dean Hickman

Nat Protoc· January 2022

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The development of a structurally distinct series of BACE1 inhibitors via the (Z)-fluoro-olefin amide bioisosteric replacement.
Michael Frohn, Longbin Liu, Aaron C Siegmund, Wenyuan Qian, Albert Amegadzie, Dean Hickman

Bioorg Med Chem Lett· July 2020

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Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2.
Liping H Pettus, Matthew P Bourbeau, Jodi Bradley, Michael D Bartberger, Kui Chen, Dean Hickman

J Med Chem· March 2020

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Application of Transmural Flow Across In Vitro Microvasculature Enables Direct Sampling of Interstitial Therapeutic Molecule Distribution.
Giovanni S Offeddu, Luca Possenti, Joshua T Loessberg-Zahl, Paolo Zunino, John Roberts, Dean Hickman

Small· November 2019

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Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species.
Robert S Foti, Kaustav Biswas, Jennifer Aral, Xuhai Be, Loren Berry, Dean Hickman

Drug Metab Dispos· October 2019

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An on-chip model of protein paracellular and transcellular permeability in the microcirculation.
Giovanni S Offeddu, Kristina Haase, Mark R Gillrie, Ran Li, Olga Morozova, Dean Hickman

Biomaterials· August 2019

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Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies.
Hui-Ling Wang, Kristin L Andrews, Shon K Booker, Jude Canon, Victor J Cee, Dean Hickman

J Med Chem· February 2019

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Development of 2-aminooxazoline 3-azaxanthene β-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D.
Jonathan D Low, Michael D Bartberger, Kui Chen, Yuan Cheng, Mark R Fielden, Dean Hickman

Medchemcomm· June 2017

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Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors.
Liping H Pettus, Kristin L Andrews, Shon K Booker, Jie Chen, Victor J Cee, Dean Hickman

J Med Chem· July 2016

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Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors.
Victor J Cee, Frank Chavez, Bradley Herberich, Brian A Lanman, Liping H Pettus, Dean Hickman

ACS Med Chem Lett· April 2016

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Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors.
Ryan P Wurz, Liping H Pettus, Kate Ashton, James Brown, Jian Jeffrey Chen, Dean Hickman

ACS Med Chem Lett· September 2015

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Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat.
Mark R Fielden, Jonathan Werner, Jeff A Jamison, Aldo Coppi, Dean Hickman

Toxicol Pathol· June 2015

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Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer's disease.
Jian Jeffrey Chen, Qingyian Liu, Chester Yuan, Vijay Gore, Patricia Lopez, Dean Hickman

Bioorg Med Chem Lett· February 2015

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An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities.
Yuan Cheng, James Brown, Ted C Judd, Patricia Lopez, Wenyuan Qian, Dean Hickman

ACS Med Chem Lett· February 2015

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Inhibitors of β-site amyloid precursor protein cleaving enzyme (BACE1): identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718).
Thomas A Dineen, Kui Chen, Alan C Cheng, Katayoun Derakhchan, Oleg Epstein, Dean Hickman

J Med Chem· December 2014

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Lead optimization and modulation of hERG activity in a series of aminooxazoline xanthene β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.
Oleg Epstein, Marian C Bryan, Alan C Cheng, Katayoun Derakhchan, Thomas A Dineen, Dean Hickman

J Med Chem· December 2014

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Intestinal and hepatic first-pass extraction of the 11β-HSD1 inhibitor AMG 221 in rats with chronic vascular catheters.
Qiuxia Gao, Robert E Kimura, Xiping Zhang, Joon Nam, Benny M Amore, Dean Hickman

Xenobiotica· March 2014

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The optimization of aminooxadiazoles as orally active inhibitors of Cdc7.
Paul E Harrington, Matthew P Bourbeau, Christopher Fotsch, Michael Frohn, Alexander J Pickrell, Dean Hickman

Bioorg Med Chem Lett· December 2013

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Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease.
Jian Jeffrey Chen, Wenyuan Qian, Kaustav Biswas, Chester Yuan, Albert Amegadzie, Dean Hickman

Bioorg Med Chem Lett· December 2013

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Quality improvement on the acute inpatient psychiatry unit using the model for improvement.
Kuldeep Singh, Joshua Sanderson, David Galarneau, Thomas Keister, Dean Hickman

Ochsner J· September 2013

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