Publications by authors named "Dean Messing"

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Anti-Drug Antibody Incidence Comparison of Therapeutic Proteins Administered Via Subcutaneous vs. Intravenous Route.
Jacob Felderman, Lila Ramaiah, Maria-Dolores Vazquez-Abad, Dean Messing, Ying Chen

AAPS J· May 2024

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Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function.
Zhenwei Su, Jonathan Brooks, Jeffrey Pelker, Tatyana Andreyeva, Hanna Sobon, Dean Messing

PLoS One· January 2023

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Application of blood microsampling in cynomolgus monkey and demonstration of equivalent monoclonal antibody PK parameters compared to conventional sampling.
Ying Wang, Sarah J Crowell, Alison Joyce, Lisa Dyleski, Dean Messing

Pharm Res· May 2021

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Safety, Tolerability, and Pharmacokinetics of PF-06823859, an Anti-Interferon β Monoclonal Antibody: A Randomized, Phase I, Single- and Multiple-Ascending-Dose Study.
Srividya Neelakantan, Barry Oemar, Kristen Johnson, Natalie Rath, Mikhail Salganik, Dean Messing

Clin Pharmacol Drug Dev· March 2021

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A Physiologically-Based Pharmacokinetic Model for the Prediction of "Half-Life Extension" and "Catch and Release" Monoclonal Antibody Pharmacokinetics.
Hannah M Jones, John Tolsma, Zhiwei Zhang, Paul Jasper, Haobin Luo, Dean Messing

CPT Pharmacometrics Syst Pharmacol· September 2020

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Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning.
Mark E Schnute, Stephen E Benoit, Ingrid P Buchler, Nicole Caspers, Margaret L Grapperhaus, Dean Messing

ACS Med Chem Lett· January 2019

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Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.
Mark E Schnute, Mattias Wennerstål, Jennifer Alley, Martin Bengtsson, James R Blinn, Dean Messing

J Med Chem· December 2018

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Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis.
Peter G Ruminski, Mark Massa, Joseph Strohbach, Cathleen E Hanau, Michelle Schmidt, Dean M Messing

J Med Chem· January 2016

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Modeling the clinical phenotype of BTK inhibition in the mature murine immune system.
Micah J Benson, Varenka Rodriguez, David von Schack, Sean Keegan, Tim A Cook, Dean Messing

J Immunol· July 2014

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Mechanistic investigations of test article-induced pancreatic toxicity at the endocrine-exocrine interface in the rat.
Karrie A Brenneman, Shashi K Ramaiah, Cynthia M Rohde, Dean M Messing, Shawn P O'Neil

Toxicol Pathol· January 2014

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Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis.
Andrew L Rankin, Nilufer Seth, Sean Keegan, Tatyana Andreyeva, Tim A Cook, Dean Messing

J Immunol· November 2013

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An improved algorithm for quantifying real-time impedance biosensor signals.
Dean S Messing, Andrey Ghindilis, Kevin Schwarzkopf

Annu Int Conf IEEE Eng Med Biol Soc· June 2012

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Development of real-time assays for impedance-based detection of microbial double-stranded DNA targets: optimization and data analysis.
Andrei L Ghindilis, Maria W Smith, Dean S Messing, Vena N Haynes, George B Middleton

Biosens Bioelectron· May 2012

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Discovery and characterization of atropisomer PH-797804, a p38 MAP kinase inhibitor, as a clinical drug candidate.
Li Xing, Balekudru Devadas, Rajesh V Devraj, Shaun R Selness, Huey Shieh, Dean Messing

ChemMedChem· February 2012

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Substituted N-aryl-6-pyrimidinones: a new class of potent, selective, and orally active p38 MAP kinase inhibitors.
Balekudru Devadas, Shaun R Selness, Li Xing, Heather M Madsen, Laura D Marrufo, Dean M Messing

Bioorg Med Chem Lett· July 2011

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Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase.
Shaun R Selness, Terri L Boehm, John K Walker, Balekudru Devadas, Richard C Durley, Dean Messing

Bioorg Med Chem Lett· July 2011

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Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase.
Shaun R Selness, Rajesh V Devraj, Balekudru Devadas, John K Walker, Terri L Boehm, Dean Messing

Bioorg Med Chem Lett· July 2011

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Impedimetric biosignal analysis and quantification in a real-time biosensor system.
Dean S Messing, Andrey Ghindilis, Kevin Schwarzkopf

Annu Int Conf IEEE Eng Med Biol Soc· March 2011

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Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: confirmation by multivariate analysis that modulation of type II collagen and aggrecan degradation peptides parallels pathologic changes.
Steven Settle, Lillian Vickery, Olga Nemirovskiy, Tom Vidmar, Alison Bendele, Dean Messing

Arthritis Rheum· October 2010

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Acute lymphoid and gastrointestinal toxicity induced by selective p38alpha map kinase and map kinase-activated protein kinase-2 (MK2) inhibitors in the dog.
Dale L Morris, Shawn P O'Neil, Rajesh V Devraj, Joseph P Portanova, Richard W Gilles, Dean M Messing

Toxicol Pathol· June 2010

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Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase.
John K Walker, Shaun R Selness, Rajesh V Devraj, Michael E Hepperle, Win Naing, Dean M Messing

Bioorg Med Chem Lett· April 2010

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Effect of compound plate composition on measurement of hERG current IC(50) using PatchXpress.
Zun-Li Mo, Tracy Faxel, Young-Sun Yang, Robert Gallavan, Dean Messing

J Pharmacol Toxicol Methods· January 2010

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Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation.
Heidi R Hope, Gary D Anderson, Barry L Burnette, Robert P Compton, Rajesh V Devraj, Dean M Messing

J Pharmacol Exp Ther· December 2009

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Predicting drug-drug interactions in drug discovery: where are we now and where are we going?
Matthew Hutzler, Dean M Messing, Larry C Wienkers

Curr Opin Drug Discov Devel· January 2005

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