Publications by authors named "Dennis Hruby"

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Editorial Expression of Concern: Development of an in vitro cleavage assay system to examine vaccinia virus I7L cysteine proteinase activity.
Chelsea M Byrd, Dennis E Hruby

Virol J· August 2025

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Tecovirimat for Clade I MPXV Infection in the Democratic Republic of Congo.

N Engl J Med· April 2025

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Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods.
Todd M Bell, Paul Facemire, Jeremy J Bearss, Jo Lynne Raymond, Jennifer Chapman, Dennis E Hruby

PLoS Pathog· February 2024

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Early administration of tecovirimat shortens the time to mpox clearance in a model of human infection.
Bach Tran Nguyen, Aurélien Marc, Clara Suñer, Michael Marks, Maria Ubals, Dennis E Hruby

PLoS Biol· December 2023

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Emerging pharmacological strategies for treating and preventing mpox.
Douglas W Grosenbach, Andrew T Russo, Emily D Blum, Dennis E Hruby

Expert Rev Clin Pharmacol· November 2023

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In vitro susceptibility of eighteen clinical isolates of human monkeypox virus to tecovirimat.
Desiree Dos Santos Nunes, Luiza M Higa, Régis Linhares Oliveira, Lendel Correia da Costa, Larissa Maciel Bomfim, Dennis E Hruby

Mem Inst Oswaldo Cruz· July 2023

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Overview of the regulatory approval of tecovirimat intravenous formulation for treatment of smallpox: potential impact on smallpox outbreak response capabilities, and future tecovirimat development potential.
Andrew T Russo, Douglas W Grosenbach, Kady M Honeychurch, Paul G Long, Dennis E Hruby

Expert Rev Anti Infect Ther· March 2023

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Tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations.
Gaëlle Frenois-Veyrat, Franck Gallardo, Olivier Gorgé, Elie Marcheteau, Olivier Ferraris, Dennis E Hruby

Nat Microbiol· December 2022

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An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications.
Andrew T Russo, Douglas W Grosenbach, Jarasvech Chinsangaram, Kady M Honeychurch, Paul G Long, Dennis E Hruby

Expert Rev Anti Infect Ther· March 2021

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Preliminary Screening and In Vitro Confirmation of Orthopoxvirus Antivirals.
Douglas W Grosenbach, Dennis E Hruby

Methods Mol Biol· March 2020

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Co-administration of tecovirimat and ACAM2000™ in non-human primates: Effect of tecovirimat treatment on ACAM2000 immunogenicity and efficacy versus lethal monkeypox virus challenge.
Andrew T Russo, Aklile Berhanu, Catherine B Bigger, Jon Prigge, Peter M Silvera, Dennis Hruby

Vaccine· January 2020

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Effects of Treatment Delay on Efficacy of Tecovirimat Following Lethal Aerosol Monkeypox Virus Challenge in Cynomolgus Macaques.
Andrew T Russo, Douglas W Grosenbach, Trevor L Brasel, Robert O Baker, Andrew G Cawthon, Dennis E Hruby

J Infect Dis· September 2018

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Oral Tecovirimat for the Treatment of Smallpox.
Douglas W Grosenbach, Kady Honeychurch, Eric A Rose, Jarasvech Chinsangaram, Annie Frimm, Dennis E Hruby

N Engl J Med· July 2018

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Treatment with the smallpox antiviral tecovirimat (ST-246) alone or in combination with ACAM2000 vaccination is effective as a postsymptomatic therapy for monkeypox virus infection.
Aklile Berhanu, Jonathan T Prigge, Peter M Silvera, Kady M Honeychurch, Dennis E Hruby

Antimicrob Agents Chemother· July 2015

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ST-246 is a key antiviral to inhibit the viral F13L phospholipase, one of the essential proteins for orthopoxvirus wrapping.
Sophie Duraffour, María M Lorenzo, Gudrun Zöller, Dimitri Topalis, Doug Grosenbach, Dennis E Hruby

J Antimicrob Chemother· May 2015

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The broad-spectrum antiviral compound ST-669 restricts chlamydial inclusion development and bacterial growth and localizes to host cell lipid droplets within treated cells.
Kelsi M Sandoz, William G Valiant, Steven G Eriksen, Dennis E Hruby, Robert D Allen

Antimicrob Agents Chemother· July 2014

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Pharmacokinetics and interspecies allometric scaling of ST-246, an oral antiviral therapeutic for treatment of orthopoxvirus infection.
Adams Amantana, Yali Chen, Shanthakumar R Tyavanagimatt, Kevin F Jones, Robert Jordan, Dennis E Hruby

PLoS One· December 2013

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Efficacy of tecovirimat (ST-246) in nonhuman primates infected with variola virus (Smallpox).
Eric M Mucker, Arthur J Goff, Joshua D Shamblin, Douglas W Grosenbach, Inger K Damon, Dennis E Hruby

Antimicrob Agents Chemother· December 2013

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Lead optimization of an acylhydrazone scaffold possessing antiviral activity against Lassa virus.
James R Burgeson, Dima N Gharaibeh, Amy L Moore, Ryan A Larson, Sean M Amberg, Dennis E Hruby

Bioorg Med Chem Lett· November 2013

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Antiviral options for biodefense.
Chelsea M Byrd, Douglas W Grosenbach, Dennis E Hruby

Curr Opin Virol· October 2013

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Novel benzoxazole inhibitor of dengue virus replication that targets the NS3 helicase.
Chelsea M Byrd, Douglas W Grosenbach, Aklile Berhanu, Dongcheng Dai, Kevin F Jones, Dennis E Hruby

Antimicrob Agents Chemother· April 2013

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Pharmacokinetic and pharmacodynamic modeling to determine the dose of ST-246 to protect against smallpox in humans.
Janet M Leeds, Frederique Fenneteau, Nathalie H Gosselin, Mohamad-Samer Mouksassi, Nastya Kassir, Dennis E Hruby

Antimicrob Agents Chemother· March 2013

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Increased susceptibility of Cantagalo virus to the antiviral effect of ST-246®.
Élida Santos-Fernandes, Cristiana O Beltrame, Chelsea M Byrd, Kara B Cardwell, Laila C Schnellrath, Dennis E Hruby

Antiviral Res· March 2013

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Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole.
Dongcheng Dai, James R Burgeson, Dima N Gharaibeh, Amy L Moore, Ryan A Larson, Dennis E Hruby

Bioorg Med Chem Lett· February 2013

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Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles.
James R Burgeson, Amy L Moore, Dima N Gharaibeh, Ryan A Larson, Natasha R Cerruti, Dennis E Hruby

Bioorg Med Chem Lett· February 2013

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