Publications by authors named "Douglas D Richardson"

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Advancing multiproduct resin reuse for development and clinical manufacturing of an antibody-based therapeutic.
Hong Li, Patricia Rose, Patricia Rowicki, Collette Cutler, Jeffrey T McPhee, Douglas D Richardson

Biotechnol Prog· June 2024

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Dissecting the Heterogeneous Glycan Profiles of Recombinant Coronavirus Spike Proteins with Individual Ion Mass Spectrometry.
Alyssa Q Stiving, David J Foreman, Zachary L VanAernum, Eberhard Durr, Shiyi Wang, Douglas D Richardson

J Am Soc Mass Spectrom· January 2024

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LC-MS Approach to Decipher a Light Chain Chromatographic Peak Splitting of a Monoclonal Antibody.
Yanjun Liu, Zac VanAernum, Yue Zhang, Xinliu Gao, Mariana Vlad, Douglas D Richardson

Pharm Res· December 2023

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Rapid Unambiguous Structure Elucidation of Streptnatamide A, a New Cyclic Peptide Isolated from A Marine-derived Streptomyces sp.
Jia-Xuan Yan, Qihao Wu, Mitasree Maity, Doug R Braun, Imraan Alas, Douglas D Richardson

Chemistry· October 2023

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Determination of ultra-trace metal-protein interactions in co-formulated monoclonal antibody drug product by SEC-ICP-MS.
Laurence Whitty-Léveillé, Zachary L VanAernum, Jorge Alexander Pavon, Christa Murphy, Katie Neal, Douglas D Richardson

MAbs· April 2023

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Analytical Performance Evaluation of Identity, Quality-Attribute Monitoring and new Peak Detection in a Platform Multi-Attribute Method Using Lys-C Digestion for Characterization and Quality Control of Therapeutic Monoclonal Antibodies.
Xuanwen Li, Nicholas A Pierson, Xiaoqing Hua, Bhumit A Patel, Michael H Olma, Douglas D Richardson

J Pharm Sci· March 2023

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Preclinical immunogenicity and efficacy of a candidate COVID-19 vaccine based on a vesicular stomatitis virus-SARS-CoV-2 chimera.
Amy S Espeseth, Maoli Yuan, Michael Citron, Lucia Reiserova, Gavin Morrow, Douglas D Richardson

EBioMedicine· August 2022

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Improvements on sample preparation and peptide separation for reduced peptide mapping based multi-attribute method analysis of therapeutic monoclonal antibodies using lysyl endopeptidase digestion.
Xuanwen Li, Baibhav Rawal, Shannon Rivera, Simon Letarte, Douglas D Richardson

J Chromatogr A· July 2022

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Automated Data Generation for Raman Spectroscopy Calibrations in Multi-Parallel Mini Bioreactors.
Alexander Graf, Angus Woodhams, Michael Nelson, Douglas D Richardson, Steven M Short

Sensors (Basel)· April 2022

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real time monitoring of emulsification and homogenization processes for vaccine adjuvants.
Nicole M Ralbovsky, Randal J Soukup, Justin P Lomont, Mackenzie L Lauro, Amanda Gulasarian, Douglas D Richardson

Analyst· January 2022

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Selective Plate-Based Assay for Trace EDTA Analysis via Boron Trifluoride-methanol Derivatization UHPLC-QqQ-MS/MS Enabling Biologic and Vaccine Processes.
Raffeal Bennett, Ryan D Cohen, Heather Wang, Tony Pereira, Mark A Haverick, Douglas D Richardson

Anal Chem· January 2022

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The measurement and control of high-risk host cell proteins for polysorbate degradation in biologics formulation.
Xuanwen Li, Fengqiang Wang, Hong Li, Douglas D Richardson, David J Roush

Antib Ther· January 2022

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Protein A does not induce allosteric structural changes in an IgG1 antibody during binding.
Juan P Rincon Pabon, Brent A Kochert, Yan-Hui Liu, Douglas D Richardson, David D Weis

J Pharm Sci· June 2021

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Profiling Active Enzymes for Polysorbate Degradation in Biotherapeutics by Activity-Based Protein Profiling.
Xuanwen Li, Divya Chandra, Simon Letarte, Gregory C Adam, Jonathan Welch, Douglas D Richardson

Anal Chem· June 2021

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Identification and characterization of a residual host cell protein hexosaminidase B associated with N-glycan degradation during the stability study of a therapeutic recombinant monoclonal antibody product.
Xuanwen Li, Yan An, Jing Liao, Li Xiao, Michael Swanson, Douglas D Richardson

Biotechnol Prog· May 2021

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Rapid two-dimensional Protein-A size exclusion chromatography of monoclonal antibodies for titer and aggregation measurements from harvested cell culture fluid samples.
Zachary D Dunn, Jayesh Desai, Gabriel M Leme, Dwight R Stoll, Douglas D Richardson

MAbs· January 2021

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Fiber-based HIC capture loop for coupling of protein A and size exclusion chromatography in a two-dimensional separation of monoclonal antibodies.
Lei Wang, Hung K Trang, Jay Desai, Zachary D Dunn, Douglas D Richardson

Anal Chim Acta· February 2020

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Targeted Host Cell Protein Quantification by LC-MRM Enables Biologics Processing and Product Characterization.
Xinliu Gao, Baibhav Rawal, Yi Wang, Xuanwen Li, David Wylie, Douglas D Richardson

Anal Chem· January 2020

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Multi-angle light scattering as a process analytical technology measuring real-time molecular weight for downstream process control.
Bhumit A Patel, Adrian Gospodarek, Michael Larkin, Sophia A Kenrick, Mark A Haverick, Douglas D Richardson

MAbs· October 2018

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On-Line Ion Exchange Liquid Chromatography as a Process Analytical Technology for Monoclonal Antibody Characterization in Continuous Bioprocessing.
Bhumit A Patel, Nuno D S Pinto, Adrian Gospodarek, Bruce Kilgore, Kudrat Goswami, Daisy Richardson, Douglas D Richardson

Anal Chem· November 2017

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A View on the Importance of "Multi-Attribute Method" for Measuring Purity of Biopharmaceuticals and Improving Overall Control Strategy.
Richard S Rogers, Michael Abernathy, Douglas D Richardson, Jason C Rouse, Justin B Sperry

AAPS J· November 2017

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Screening hydrolysis products of sulfur mustard agents by high-performance liquid chromatography with inductively coupled plasma mass spectrometry detection.
Karolin K Kroening, Douglas D Richardson, Scott Afton, Joseph A Caruso

Anal Bioanal Chem· April 2009

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Detection of chemical warfare agent degradation products in foods using liquid chromatography coupled to inductively coupled plasma mass spectrometry and electrospray ionization mass spectrometry.
Kevin M Kubachka, Douglas D Richardson, Douglas T Heitkemper, Joseph A Caruso

J Chromatogr A· August 2008

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Screening organophosphorus nerve agent degradation products in pesticide mixtures by GC-ICPMS.
Douglas D Richardson, Joseph A Caruso

Anal Bioanal Chem· October 2007

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Derivatization of organophosphorus nerve agent degradation products for gas chromatography with ICPMS and TOF-MS detection.
Douglas D Richardson, Joseph A Caruso

Anal Bioanal Chem· June 2007

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