Publications by authors named "David D Weis"

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Discovery of Potent and Selective Reversible Ubiquitin-Like Modifier Activating Enzyme 5 Inhibitors Targeting the UFMylation Pathway.
James J Mignone, Elizabeth A Jurica, Deepa Rajasekaran, Jaclyn Robustelli, Courtney McCarthy, David D Weis

J Med Chem· October 2025

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: A Feature Extraction Algorithm for Hydrogen Exchange-Mass Spectrometry Based on a Linear Deuteration Model and LASSO Regularization.
Yuqi Shi, Jarod Hart, David D Weis

Anal Chem· October 2025

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Rigorous Analysis of Multimodal HDX-MS Spectra.
Lisa M Tuttle, Ellie I James, Florian Georgescauld, Thomas E Wales, David D Weis

J Am Soc Mass Spectrom· February 2025

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Understanding the Effects of Site-Specific Light Chain Conjugation on Antibody Structure Using Hydrogen Exchange-Mass Spectrometry (HX-MS).
Sachini P Karunaratne, Ehab M Moussa, Brittney J Mills, David D Weis

J Pharm Sci· August 2024

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Evaluation of Proteolytic Digestion Efficiency in Hydrogen Exchange-Mass Spectrometry Experiments Using the Digestible Peptide Score.
Michael S Wrigley, Juan P Rincon Pabon, David D Weis

J Am Soc Mass Spectrom· July 2024

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Single-domain antibodies reveal unique borrelicidal epitopes on the Lyme disease vaccine antigen, outer surface protein A (OspA).
David J Vance, Saiful Basir, Carol Lyn Piazza, Graham G Willsey, H M Emranul Haque, David D Weis

Infect Immun· April 2024

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Optimization of a Hydrogen Exchange-Mass Spectrometry Robotic Liquid Handler Using Tracers.
Michael S Wrigley, Hayley Blockinger, H M Emranul Haque, Sachini P Karunaratne, David D Weis

Anal Chem· January 2024

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Interaction between preservatives and a monoclonal antibody in support of multidose formulation development.
Sachini P Karunaratne, Madeleine C Jolliffe, Isabelle Trayton, Ramesh Kumar Shanmugam, Nicholas J Darton, David D Weis

Int J Pharm· December 2023

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Structure of a transmission blocking antibody in complex with Outer surface protein A from the Lyme disease spirochete, Borreliella burgdorferi.
Michael J Rudolph, Simon A Davis, H M Emranul Haque, Monir Ejemel, Lisa A Cavacini, David D Weis

Proteins· November 2023

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Structural Elucidation of a Protective B Cell Epitope on Outer Surface Protein C (OspC) of the Lyme Disease Spirochete, Borreliella burgdorferi.
Michael J Rudolph, Simon A Davis, H M Emranul Haque, David D Weis, David J Vance

mBio· April 2023

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High-Throughput Epitope Mapping by Hydrogen Exchange-Mass Spectrometry.
H M Emranul Haque, Nicholas J Mantis, David D Weis

J Am Soc Mass Spectrom· January 2023

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Human B Cell Epitope Map of the Lyme Disease Vaccine Antigen, OspA.
H M Emranul Haque, Monir Ejemel, David J Vance, Graham Willsey, Michael J Rudolph, David D Weis

ACS Infect Dis· December 2022

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Identification of Agitation-Induced Unfolding Events Causing Aggregation of Monoclonal Antibodies Using Hydrogen Exchange-Mass Spectrometry.
Chamalee L D Gamage, David D Weis, Benjamin T Walters

J Pharm Sci· August 2022

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Interaction of Aluminum-adjuvanted Recombinant P[4] Protein Antigen With Preservatives: Storage Stability and Backbone Flexibility Studies.
Nishant Sawant, Sangeeta B Joshi, David D Weis, David B Volkin

J Pharm Sci· April 2022

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Rapid Assessment of Pepsin Column Activity for Reliable HDX-MS Studies.
Clint Vorauer, Michael S Wrigley, Juan P Rincon Pabon, Michael J Watson, Charlie C Mundorff, David D Weis

J Am Soc Mass Spectrom· September 2021

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Recommendations for the Propagation of Uncertainty in Hydrogen Exchange-Mass Spectrometric Measurements.
David D Weis

J Am Soc Mass Spectrom· July 2021

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Protein A does not induce allosteric structural changes in an IgG1 antibody during binding.
Juan P Rincon Pabon, Brent A Kochert, Yan-Hui Liu, Douglas D Richardson, David D Weis

J Pharm Sci· June 2021

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In Vivo Reoxidation Kinetics of Free Thiols in Multiple Domains of IgG1 Antibodies in Rats.
Michael T Kim, Martin Lechmann, Sharmila Rajan, Vittal Shivva, Aron Lee, David D Weis

J Pharm Sci· May 2021

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Statistical Equivalence Testing of Higher-Order Protein Structures with Differential Hydrogen Exchange-Mass Spectrometry (HX-MS).
Tyler S Hageman, Michael S Wrigley, David D Weis

Anal Chem· May 2021

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Mechanism of Thimerosal-Induced Structural Destabilization of a Recombinant Rotavirus P[4] Protein Antigen Formulated as a Multi-Dose Vaccine.
Kawaljit Kaur, Jian Xiong, Nishant Sawant, Sanjeev Agarwal, John M Hickey, David D Weis

J Pharm Sci· March 2021

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Characterization of Excipient Effects on Reversible Self-Association, Backbone Flexibility, and Solution Properties of an IgG1 Monoclonal Antibody at High Concentrations: Part 2.
Yue Hu, Ronald T Toth, Sangeeta B Joshi, Reza Esfandiary, C Russell Middaugh, David D Weis

J Pharm Sci· January 2020

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Characterization of Excipient Effects on Reversible Self-Association, Backbone Flexibility, and Solution Properties of an IgG1 Monoclonal Antibody at High Concentrations: Part 1.
Yue Hu, Jayant Arora, Sangeeta B Joshi, Reza Esfandiary, C Russell Middaugh, David D Weis

J Pharm Sci· January 2020

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Multifaceted assessment of rituximab biosimilarity: The impact of glycan microheterogeneity on Fc function.
Jukyung Kang, Sang Yeop Kim, Daniel Vallejo, Tyler S Hageman, Derek R White, David D Weis

Eur J Pharm Biopharm· January 2020

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Reliable Identification of Significant Differences in Differential Hydrogen Exchange-Mass Spectrometry Measurements Using a Hybrid Significance Testing Approach.
Tyler S Hageman, David D Weis

Anal Chem· July 2019

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Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.
Glenn R Masson, John E Burke, Natalie G Ahn, Ganesh S Anand, Christoph Borchers, David D Weis

Nat Methods· July 2019

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