Publications by authors named "Edna Choo"

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Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1.
John C Tellis, BinQing Wei, Michael Siu, Le An, Grace Kayan Chan, Edna F Choo

ACS Med Chem Lett· September 2024

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Identification of a Discrete Diglucuronide of GDC-0810 in Human Plasma after Oral Administration.
Chenghong Zhang, Dian Su, Edna F Choo, Lichuan Liu, Sudheer Bobba

Drug Metab Dispos· October 2023

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Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).
Bryan K Chan, Eileen Seward, Michael Lainchbury, Thomas F Brewer, Le An, Edna F Choo

ACS Med Chem Lett· January 2022

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Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models.
Raghuveer Singh Mali, Qi Zhang, Rosa Anna DeFilippis, Antonio Cavazos, Vinitha Mary Kuruvilla, Edna F Choo

Haematologica· April 2021

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Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-X Inhibitor.
Le Wang, George A Doherty, Andrew S Judd, Zhi-Fu Tao, T Matthew Hansen, Edna F Choo

ACS Med Chem Lett· October 2020

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Bioactivation of ,-Unsaturated Carboxylic Acids Through Acyl Glucuronidation.
Teresa Mulder, Sudheer Bobba, Kevin Johnson, Jessica M Grandner, Wei Wang, Edna F Choo

Drug Metab Dispos· September 2020

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Preclinical Safety Assessment of a Highly Selective and Potent Dual Small-Molecule Inhibitor of CBP/P300 in Rats and Dogs.
Paula Katavolos, Gary Cain, Cindy Farman, F Anthony Romero, Steven Magnuson, Edna F Choo

Toxicol Pathol· April 2020

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Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity.
Naomi S Rajapaksa, Alberto Gobbi, Joy Drobnick, Steven Do, Aleksandr Kolesnikov, Edna F Choo

ACS Med Chem Lett· March 2020

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Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors.
Marian C Bryan, Joy Drobnick, Alberto Gobbi, Aleksandr Kolesnikov, Yongsheng Chen, Edna F Choo

J Med Chem· July 2019

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Effect of OATP1B1/1B3 Inhibitor GDC-0810 on the Pharmacokinetics of Pravastatin and Coproporphyrin I/III in Healthy Female Subjects.
Lichuan Liu, Sravanthi Cheeti, Kenta Yoshida, Edna Choo, Eugene Chen

J Clin Pharmacol· November 2018

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Assessment of OATP transporter-mediated drug-drug interaction using physiologically-based pharmacokinetic (PBPK) modeling - a case example.
Yuan Chen, Rui Zhu, Fang Ma, Jialin Mao, Eugene C Chen, Edna F Choo

Biopharm Drug Dispos· November 2018

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Practical strategies when using a stable isotope labeled microtracer for absolute bioavailability assessment: A case study of a high oral dose clinical candidate GDC-0810.
Buyun Chen, Pingping Lu, Dugan Freeman, Yang Gao, Edna Choo

J Pharm Biomed Anal· May 2018

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Leveraging Humanized Animal Models to Understand Human Drug Disposition: Opportunities, Challenges, and Future Directions.
Edna F Choo, Laurent Salphati

Clin Pharmacol Ther· February 2018

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Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300.
Kwong Wah Lai, F Anthony Romero, Vickie Tsui, Maureen H Beresini, Gladys de Leon Boenig, Edna F Choo

Bioorg Med Chem Lett· January 2018

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A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors.
Sarah M Bronner, Jeremy Murray, F Anthony Romero, Kwong Wah Lai, Vickie Tsui, Edna F Choo

J Med Chem· December 2017

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GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
F Anthony Romero, Jeremy Murray, Kwong Wah Lai, Vickie Tsui, Brian K Albrecht, Edna F Choo

J Med Chem· November 2017

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Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer.
Lingyan Jin, Jesse Garcia, Emily Chan, Cecile de la Cruz, Ehud Segal, Edna Choo

Cancer Res· October 2017

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Utility of CYP3A4 and PXR-CAR-CYP3A4/3A7 Transgenic Mouse Models To Assess the Magnitude of CYP3A4 Mediated Drug-Drug Interactions.
Justin Q Ly, Kirsten Messick, Ann Qin, Ryan H Takahashi, Edna F Choo

Mol Pharm· May 2017

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Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs.
Ryan H Takahashi, Shuguang Ma, Qin Yue, Heasook Kim-Kang, Yijun Yi, Edna F Choo

Xenobiotica· January 2017

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Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.
Terry D Crawford, F Anthony Romero, Kwong Wah Lai, Vickie Tsui, Alexander M Taylor, Edna F Choo

J Med Chem· December 2016

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Nonselective inhibition of the epigenetic transcriptional regulator BET induces marked lymphoid and hematopoietic toxicity in mice.
Dong U Lee, Paula Katavolos, Gopinath Palanisamy, Arna Katewa, Charly Sioson, Edna Choo

Toxicol Appl Pharmacol· June 2016

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Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans.
Ryan H Takahashi, Edna F Choo, Shuguang Ma, Susan Wong, Jason Halladay

Drug Metab Dispos· January 2016

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Elucidating the Mechanisms of Formation for Two Unusual Cytochrome P450-Mediated Fused Ring Metabolites of GDC-0623, a MAPK/ERK Kinase Inhibitor.
Ryan H Takahashi, Shuguang Ma, Sarah J Robinson, Qin Yue, Edna F Choo

Drug Metab Dispos· December 2015

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Use of transgenic mouse models to understand the oral disposition and drug-drug interaction potential of cobimetinib, a MEK inhibitor.
Edna F Choo, Sarah Woolsey, Kevin DeMent, Justin Ly, Kirsten Messick

Drug Metab Dispos· June 2015

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Determination of cobimetinib in human plasma using protein precipitation extraction and high-performance liquid chromatography coupled to mass spectrometry.
Yuzhong Deng, Luna Musib, Edna Choo, Matthew Chapple, Sarah Burke

J Chromatogr B Analyt Technol Biomed Life Sci· December 2014

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