Publications by authors named "Edward Giardino"

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High-content assays for evaluating cellular and hepatic diacylglycerol acyltransferase activity.
Jenson Qi, Wensheng Lang, Edward Giardino, Gary W Caldwell, Charles Smith

J Lipid Res· December 2010

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Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibition.
Margery A Connelly, Tom J Parry, Edward C Giardino, Zhihong Huang, Wai-Man Cheung

J Cardiovasc Pharmacol· May 2010

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Cooperative antithrombotic effect from the simultaneous inhibition of thrombin and factor Xa.
Edward C Giardino, Barbara J Haertlein, Lawrence de Garavilla, Michael J Costanzo, Bruce P Damiano

Blood Coagul Fibrinolysis· March 2010

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Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif.
Tianbao Lu, Thomas Markotan, Shelley K Ballentine, Edward C Giardino, John Spurlino

J Med Chem· February 2010

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Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif.
Kevin D Kreutter, Tianbao Lu, Lily Lee, Edward C Giardino, Sharmila Patel

Bioorg Med Chem Lett· May 2008

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7-fluoroindazoles as potent and selective inhibitors of factor Xa.
Yu-Kai Lee, Daniel J Parks, Tianbao Lu, Tho V Thieu, Thomas Markotan, Edward C Giardino

J Med Chem· January 2008

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Exploration of potential prodrugs of RWJ-445167, an oxyguanidine-based dual inhibitor of thrombin and factor Xa.
Bruce E Maryanoff, David F McComsey, Michael J Costanzo, Stephen C Yabut, Tianbao Lu, Edward C Giardino

Chem Biol Drug Des· July 2006

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A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.
Lawrence de Garavilla, Michael N Greco, Narayanasami Sukumar, Zhi-Wei Chen, Agustin O Pineda, Edward C Giardino

J Biol Chem· May 2005

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In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
Michael J Costanzo, Harold R Almond, Leonard R Hecker, Mary R Schott, Stephen C Yabut, Edward C Giardino

J Med Chem· March 2005

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Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis.
Tianbao Lu, Thomas Markotan, Frank Coppo, Bruce Tomczuk, Carl Crysler, Edward C Giardino

Bioorg Med Chem Lett· July 2004

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