Publications by authors named "Elizabeth Hardaker"

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Hybrid IgE-IgG1 antibodies (IgEG): a new antibody class that combines IgE and IgG functionality.
Melanie Grandits, Lais C G F Palhares, Olivia Macleod, John Devlin, Oliver E Amin, Elizabeth Hardaker

MAbs· December 2025

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Fc-mediated immune stimulating, pro-inflammatory and antitumor effects of anti-HER2 IgE against HER2-expressing and trastuzumab-resistant tumors.
Melanie Grandits, Lais C G F Palhares, Gabriel Osborn, Jitesh Chauhan, Katie Stoker, Elizabeth Hardaker

J Immunother Cancer· March 2025

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An IgE antibody targeting HER2 identified by clonal selection restricts breast cancer growth via immune-stimulating activities.
Lais C G F Palhares, Melanie Grandits, Katie Stoker, Jitesh Chauhan, Heng Sheng Sow, Elizabeth Hardaker

J Exp Clin Cancer Res· February 2025

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Efficacy and pharmacodynamic effect of anti-CD73 and anti-PD-L1 monoclonal antibodies in combination with cytotoxic therapy: observations from mouse tumor models.
Brajesh P Kaistha, Gozde Kar, Andreas Dannhorn, Amanda Watkins, Grace Opoku-Ansah, Elizabeth Hardaker

Cancer Biol Ther· December 2024

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The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment.
Elizabeth L Hardaker, Emilio Sanseviero, Ankur Karmokar, Devon Taylor, Marta Milo

Nat Commun· February 2024

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Optimization of an Imidazo[1,2-]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with Efficacy.
William McCoull, Scott Boyd, Martin R Brown, Muireann Coen, Olga Collingwood, Elizabeth Hardaker

J Med Chem· September 2021

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Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy.
J Willem M Nissink, Sana Bazzaz, Carolyn Blackett, Matthew A Clark, Olga Collingwood, Elizabeth Hardaker

J Med Chem· March 2021

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Development of autotaxin inhibitors: A series of tetrazole cinnamides.
Christopher G Thomson, Darren Le Grand, Mark Dowling, David Beattie, Lucy Elphick, Elizabeth Hardaker

Bioorg Med Chem Lett· January 2021

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Development of an ObLiGaRe Doxycycline Inducible Cas9 system for pre-clinical cancer drug discovery.
Anders Lundin, Michelle J Porritt, Himjyot Jaiswal, Frank Seeliger, Camilla Johansson, Elizabeth Hardaker

Nat Commun· September 2020

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A multi-batch design to deliver robust estimates of efficacy and reduce animal use - a syngeneic tumour case study.
Natasha A Karp, Zena Wilson, Eve Stalker, Lorraine Mooney, Stanley E Lazic, Elizabeth Hardaker

Sci Rep· April 2020

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Longitudinal immune characterization of syngeneic tumor models to enable model selection for immune oncology drug discovery.
Molly A Taylor, Adina M Hughes, Josephine Walton, Anna M L Coenen-Stass, Lukasz Magiera, Elizabeth L Hardaker

J Immunother Cancer· November 2019

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Randomized Placebo-Controlled Trial Evaluating the Ophthalmic Safety of Single-Dose Tafenoquine in Healthy Volunteers.
Jessica Ackert, Khadeeja Mohamed, Jason S Slakter, Sherif El-Harazi, Alessandro Berni, Elizabeth Hardaker

Drug Saf· September 2019

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Single-Dose Tafenoquine to Prevent Relapse of Plasmodium vivax Malaria.
Marcus V G Lacerda, Alejandro Llanos-Cuentas, Srivicha Krudsood, Chanthap Lon, David L Saunders, Elizabeth Hardaker

N Engl J Med· January 2019

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Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax Malaria.
Alejandro Llanos-Cuentas, Marcus V G Lacerda, Tran T Hien, Iván D Vélez, Chayadol Namaik-Larp, Elizabeth Hardaker

N Engl J Med· January 2019

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PI3Kα/δ inhibition promotes anti-tumor immunity through direct enhancement of effector CD8 T-cell activity.
Larissa S Carnevalli, Charles Sinclair, Molly A Taylor, Pablo Morentin Gutierrez, Sophie Langdon, Elizabeth Hardaker

J Immunother Cancer· December 2018

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Development of autotaxin inhibitors: A series of zinc binding triazoles.
Christopher G Thomson, Darren Le Grand, Mark Dowling, Cara E Brocklehurst, Colin Chinn, Elizabeth Hardaker

Bioorg Med Chem Lett· July 2018

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Functional significance of co-occurring mutations in and in breast cancer.
Alvaro Avivar-Valderas, Robert McEwen, Amir Taheri-Ghahfarokhi, Larissa S Carnevalli, Elizabeth L Hardaker

Oncotarget· April 2018

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Characterisation of lung macrophage subpopulations in COPD patients and controls.
Jennifer A Dewhurst, Simon Lea, Elizabeth Hardaker, Josiah V Dungwa, Arjun K Ravi

Sci Rep· August 2017

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Liver X receptor agonists increase airway reactivity in a model of asthma via increasing airway smooth muscle growth.
Mark A Birrell, Jorge De Alba, Matthew C Catley, Elizabeth Hardaker, Sissie Wong

J Immunol· September 2008

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Estrogen receptor beta: expression profile and possible anti-inflammatory role in disease.
Matthew C Catley, Mark A Birrell, Elizabeth L Hardaker, Jorge de Alba, Stuart Farrow

J Pharmacol Exp Ther· July 2008

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Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses.
Mark A Birrell, Matthew C Catley, Elizabeth Hardaker, Sissie Wong, Timothy M Willson

J Biol Chem· November 2007

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IkappaB kinase-2-independent and -dependent inflammation in airway disease models: relevance of IKK-2 inhibition to the clinic.
Mark A Birrell, Sissie Wong, Elizabeth L Hardaker, Matthew C Catley, Kerryn McCluskie

Mol Pharmacol· June 2006

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Second-generation inhibitors demonstrate the involvement of p38 mitogen-activated protein kinase in post-transcriptional modulation of inflammatory mediator production in human and rodent airways.
Mark A Birrell, Sissie Wong, Kerryn McCluskie, Matthew C Catley, Elizabeth L Hardaker

J Pharmacol Exp Ther· March 2006

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Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma.
Mark A Birrell, Elizabeth Hardaker, Sissie Wong, Kerryn McCluskie, Matthew Catley

Am J Respir Crit Care Med· October 2005

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Steroid-resistant inflammation in a rat model of chronic obstructive pulmonary disease is associated with a lack of nuclear factor-kappaB pathway activation.
Mark A Birrell, Sissie Wong, David J Hele, Kerryn McCluskie, Elizabeth Hardaker

Am J Respir Crit Care Med· July 2005

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