Publications by authors named "Erica L Jackson"

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STX-721, a Covalent EGFR/HER2 Exon 20 Inhibitor, Utilizes Exon 20-Mutant Dynamic Protein States and Achieves Unique Mutant Selectivity Across Human Cancer Models.
Raymond A Pagliarini, Jack A Henderson, Benjamin C Milgram, Deanna R Borrelli, Natasja Brooijmans, Erica L Jackson

Clin Cancer Res· July 2025

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Discovery of STX-721, a Covalent, Potent, and Highly Mutant-Selective EGFR/HER2 Exon20 Insertion Inhibitor for the Treatment of Non-Small Cell Lung Cancer.
Benjamin C Milgram, Deanna R Borrelli, Natasja Brooijmans, Jack A Henderson, Brendan J Hilbert, Erica L Jackson

J Med Chem· February 2025

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ORIC-101, a Glucocorticoid Receptor Antagonist, in Combination with Nab-Paclitaxel in Patients with Advanced Solid Tumors.
Christopher T Chen, Vishesh Khanna, Shivaani Kummar, Raghad M Abdul-Karim, David Sommerhalder, Erica L Jackson

Cancer Res Commun· September 2024

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STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts.
Leonard Buckbinder, David J St Jean, Trang Tieu, Brendon Ladd, Brendan Hilbert, Erica L Jackson

Cancer Discov· November 2023

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Precision Oncology Comes of Age: Designing Best-in-Class Small Molecules by Integrating Two Decades of Advances in Chemistry, Target Biology, and Data Science.
Darrin D Stuart, Angel Guzman-Perez, Natasja Brooijmans, Erica L Jackson, Gregory V Kryukov

Cancer Discov· October 2023

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EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS tumor development and propagation.
Ariel Pribluda, Anneleen Daemen, Anthony Nelson Lima, Xi Wang, Marc Hafner, Erica L Jackson

Elife· August 2022

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NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma.
Ganapati V Hegde, Cecile de la Cruz, Jennifer M Giltnane, Lisa Crocker, Avinashnarayan Venkatanarayan, Erica L Jackson

Elife· May 2019

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The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors.
Thijs J Hagenbeek, Joshua D Webster, Noelyn M Kljavin, Matthew T Chang, Trang Pham, Erica L Jackson

Sci Signal· September 2018

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Antibody-mediated stabilization of NRG1 induces behavioral and electrophysiological alterations in adult mice.
Sara L Dominguez, Ganapati V Hegde, Jesse E Hanson, Hong Xiang, Danielle Mandikian, Erica L Jackson

Sci Rep· May 2018

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Intratumoral Heterogeneity: From Diversity Comes Resistance.
Ariel Pribluda, Cecile C de la Cruz, Erica L Jackson

Clin Cancer Res· July 2015

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Lymph node-independent liver metastasis in a model of metastatic colorectal cancer.
Ida B Enquist, Zinaida Good, Adrian M Jubb, Germaine Fuh, Xi Wang, Erica L Jackson

Nat Commun· March 2014

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A rare population of CD24(+)ITGB4(+)Notch(hi) cells drives tumor propagation in NSCLC and requires Notch3 for self-renewal.
Yanyan Zheng, Cecile C de la Cruz, Leanne C Sayles, Chris Alleyne-Chin, Dedeepya Vaka, Erica L Jackson

Cancer Cell· July 2013

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Residual tumor cells that drive disease relapse after chemotherapy do not have enhanced tumor initiating capacity.
Ganapati V Hegde, Cecile de la Cruz, Jeffrey Eastham-Anderson, Yanyan Zheng, E Alejandro Sweet-Cordero, Erica L Jackson

PLoS One· April 2013

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Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF-induced neutrophil recruitment.
Vernon T Phan, Xiumin Wu, Jason H Cheng, Rebecca X Sheng, Alicia S Chung, Erica L Jackson

Proc Natl Acad Sci U S A· April 2013

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Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer.
Ganapati V Hegde, Cecile C de la Cruz, Cecilia Chiu, Navneet Alag, Gabriele Schaefer, Erica L Jackson

Sci Transl Med· February 2013

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Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model.
Sheila Alcantara Llaguno, Jian Chen, Chang-Hyuk Kwon, Erica L Jackson, Yanjiao Li

Cancer Cell· January 2009

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Characterization of adult neural stem cells and their relation to brain tumors.
Erica L Jackson, Arturo Alvarez-Buylla

Cells Tissues Organs· September 2008

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PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling.
Erica L Jackson, Jose Manuel Garcia-Verdugo, Sara Gil-Perotin, Monica Roy, Alfredo Quinones-Hinojosa

Neuron· July 2006

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The differential effects of mutant p53 alleles on advanced murine lung cancer.
Erica L Jackson, Kenneth P Olive, David A Tuveson, Roderick Bronson, Denise Crowley

Cancer Res· November 2005

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Identification of bronchioalveolar stem cells in normal lung and lung cancer.
Carla F Bender Kim, Erica L Jackson, Amber E Woolfenden, Sharon Lawrence, Imran Babar

Cell· June 2005

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Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.
David A Tuveson, Alice T Shaw, Nicholas A Willis, Daniel P Silver, Erica L Jackson

Cancer Cell· April 2004

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