Publications by authors named "Erin Code"

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Discovery of Pyrimidoindolones as Novel Family VIII Bromodomain Binders.
Jeffrey A Boerth, Marianne Schimpl, Simon C C Lucas, Jingwen Zhang, Erin L Code

ACS Med Chem Lett· June 2025

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Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design.
Taylor R Quinn, Kathryn A Giblin, Clare Thomson, Jeffrey A Boerth, Gayathri Bommakanti, Erin Code

J Med Chem· August 2024

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Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors.
Adelphe M Mfuh, Jeffrey A Boerth, Gayathri Bommakanti, Christina Chan, Alex J Chinn, Erin Code

J Med Chem· January 2024

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Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity.
Jeffrey A Boerth, Alex J Chinn, Marianne Schimpl, Gayathri Bommakanti, Christina Chan, Erin L Code

ACS Med Chem Lett· December 2023

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Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase.
Sharan K Bagal, Clare Gregson, Daniel H O' Donovan, Kurt G Pike, Andrew Bloecher, Erin Code

J Med Chem· December 2021

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Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase.
Daniel H O' Donovan, Clare Gregson, Martin J Packer, Ryan Greenwood, Kurt G Pike, Erin Code

Bioorg Med Chem Lett· May 2021

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EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex.
Jessie Hao-Ru Hsu, Timothy Rasmusson, James Robinson, Fiona Pachl, Jon Read, Erin Code

Cell Chem Biol· January 2020

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Rapid Identification of Novel Allosteric PRC2 Inhibitors.
Jon A Read, Jonathan Tart, Philip B Rawlins, Clare Gregson, Karen Jones, Erin Code

ACS Chem Biol· October 2019

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Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.
William McCoull, Tony Cheung, Erica Anderson, Peter Barton, Jonathan Burgess, Erin Code

ACS Chem Biol· November 2018

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Correction to Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
William McCoull, Roman D Abrams, Erica Anderson, Kevin Blades, Peter Barton, Erin Code

J Med Chem· July 2017

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Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
William McCoull, Roman D Abrams, Erica Anderson, Kevin Blades, Peter Barton, Erin Code

J Med Chem· May 2017

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Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.
Nelson B Olivier, Roger B Altman, Jonas Noeske, Gregory S Basarab, Erin Code

Proc Natl Acad Sci U S A· November 2014

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Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1.
Jiaquan Wu, Keith Mikule, Wenxian Wang, Nancy Su, Philip Petteruti, Erin Code

ACS Chem Biol· October 2013

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Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases.
Les A Dakin, Michael H Block, Huawei Chen, Erin Code, James E Dowling

Bioorg Med Chem Lett· July 2012

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Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent.
Maria-Elena Theoclitou, Brian Aquila, Michael H Block, Patrick J Brassil, Lillian Castriotta, Erin Code

J Med Chem· October 2011

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Biochemical characterization of human SET and MYND domain-containing protein 2 methyltransferase.
Jiaquan Wu, Tony Cheung, Christie Grande, Andrew D Ferguson, Xiahui Zhu, Erin Code

Biochemistry· July 2011

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