Publications by authors named "Jon Read"

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AMP-activated protein kinase activation suppresses leptin expression independently of adipogenesis in primary murine adipocytes.
Sophia Bustraan, Jane Bennett, Chad Whilding, Betheney R Pennycook, David Smith, Jon Read

Biochem J· March 2024

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Screening Ultra-Large Encoded Compound Libraries Leads to Novel Protein-Ligand Interactions and High Selectivity.
Gavin W Collie, Matthew A Clark, Anthony D Keefe, Andrew Madin, Jon A Read

J Med Chem· January 2024

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Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Neil P Grimster, Lakshmaiah Gingipalli, Amber Balazs, Bernard Barlaam, Scott Boiko, Jon Read

Bioorg Med Chem Lett· July 2023

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Drug discovery for epigenetics targets.
Geoffrey A Holdgate, Catherine Bardelle, Alice Lanne, Jon Read, Daniel H O'Donovan

Drug Discov Today· April 2022

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Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase.
Sharan K Bagal, Clare Gregson, Daniel H O' Donovan, Kurt G Pike, Andrew Bloecher, Jon A Read

J Med Chem· December 2021

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Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase.
Daniel H O' Donovan, Clare Gregson, Martin J Packer, Ryan Greenwood, Kurt G Pike, Jon Read

Bioorg Med Chem Lett· May 2021

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Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bernard Barlaam, Scott Boiko, Scott Boyd, Hannah Dry, Lakshmaiah Gingipalli, Jon Read

Bioorg Med Chem Lett· November 2020

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Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Neil P Grimster, Lakshmaiah Gingipalli, Bernard Barlaam, Qibin Su, XiaoLan Zheng, Jon Read

Bioorg Med Chem Lett· October 2020

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Identification of a novel series of azabenzimidazole-derived inhibitors of spleen tyrosine kinase.
Sameer P Kawatkar, Bernard Barlaam, Paul Kemmitt, Iain Simpson, David Watson, Jon Read

Bioorg Med Chem Lett· September 2020

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Discovery of (2)--[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor.
Qibin Su, Erica Banks, Geraldine Bebernitz, Kirsten Bell, Cassandra F Borenstein, Jon A Read

J Med Chem· May 2020

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EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex.
Jessie Hao-Ru Hsu, Timothy Rasmusson, James Robinson, Fiona Pachl, Jon Read

Cell Chem Biol· January 2020

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Rapid Identification of Novel Allosteric PRC2 Inhibitors.
Jon A Read, Jonathan Tart, Philip B Rawlins, Clare Gregson, Karen Jones

ACS Chem Biol· October 2019

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Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase.
Jon Read, Iain T Collie, Michelle Nguyen-McCarty, Christopher Lucaj, James Robinson

Bioorg Med Chem Lett· August 2019

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AMPK activation protects against diet induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue.
Alice E Pollard, Luís Martins, Phillip J Muckett, Sanjay Khadayate, Aurélie Bornot, Jon A Read

Nat Metab· March 2019

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Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors.
Neil P Grimster, Erica Anderson, Marat Alimzhanov, Geraldine Bebernitz, Kirsten Bell, Jon A Read

J Med Chem· June 2018

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Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.
Bin Yang, Melissa M Vasbinder, Alexander W Hird, Qibin Su, Haixia Wang, Jon A Read

J Med Chem· February 2018

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X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.
Michael R Witten, Lisa Wissler, Melanie Snow, Stefan Geschwindner, Jon A Read

J Med Chem· November 2017

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Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease.
Fernando Orden Rueda, Michal Bista, Matthew D Newton, Anne U Goeppert, M Emanuela Cuomo, Jon A Read

Nat Commun· November 2017

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Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells.
Robin Willows, Matthew J Sanders, Bing Xiao, Bhakti R Patel, Stephen R Martin, Jon Read

Biochem J· August 2017

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Effect of different γ-subunit isoforms on the regulation of AMPK.
Robin Willows, Naveenan Navaratnam, Ana Lima, Jon Read, David Carling

Biochem J· May 2017

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Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology.
Holly H Soutter, Paolo Centrella, Matthew A Clark, John W Cuozzo, Christoph E Dumelin, Jon A Read

Proc Natl Acad Sci U S A· December 2016

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Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival.
Jason G Kettle, Husam Alwan, Michal Bista, Jason Breed, Nichola L Davies, Jon Read

J Med Chem· March 2016

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Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis.
Anna A Marusiak, Natalie L Stephenson, Hayeon Baik, Eleanor W Trotter, Yaoyong Li, Jon A Read

Cancer Res· February 2016

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Identification of azabenzimidazoles as potent JAK1 selective inhibitors.
Melissa M Vasbinder, Marat Alimzhanov, Martin Augustin, Geraldine Bebernitz, Kirsten Bell, Jon Read

Bioorg Med Chem Lett· January 2016

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Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering.
Jeffrey W Johannes, Lynsie Almeida, Kevin Daly, Andrew D Ferguson, Shaun E Grosskurth, Jon A Read

Bioorg Med Chem Lett· December 2015

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