Publications by authors named "Eva Istvan"

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Revisiting the druggable genome using predicted structures and data mining.
Karla P Godinez-Macias, Daisy Chen, J Lincoln Wallis, Miles G Siegel, Anna Adam, Eva S Istvan

NPJ Drug Discov· March 2025

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The NCR1 transporter is an antimalarial target that exports cholesterol from the parasite's plasma membrane.
Zhemin Zhang, Meinan Lyu, Xu Han, Sepalika Bandara, Meng Cui, Eva S Istvan

Sci Adv· December 2024

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Systematic in vitro evolution in reveals key determinants of drug resistance.
Madeline R Luth, Karla P Godinez-Macias, Daisy Chen, John Okombo, Vandana Thathy, Eva S Istvan

Science· November 2024

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Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining.
Karla P Godinez-Macias, Daisy Chen, J Lincoln Wallis, Miles G Siegel, Anna Adam, Eva S Istvan

Res Sq· November 2024

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Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
Stanley C Xie, Yinuo Wang, Craig J Morton, Riley D Metcalfe, Con Dogovski, Eva S Istvan

Nat Commun· January 2024

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Reaction hijacking inhibition of asparagine tRNA synthetase.
Stanley C Xie, Yinuo Wang, Craig J Morton, Riley D Metcalfe, Con Dogovski, Eva S Istvan

Res Sq· July 2023

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Human Polo-like Kinase Inhibitors as Antiplasmodials.
Monica J Bohmer, Jinhua Wang, Eva S Istvan, Madeline R Luth, Jennifer E Collins

ACS Infect Dis· April 2023

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Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target.
Eva S Istvan, Francisco Guerra, Matthew Abraham, Kuo-Sen Huang, Frances Rocamora

Sci Transl Med· March 2023

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The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.
James M Murithi, Ioanna Deni, Charisse Flerida A Pasaje, John Okombo, Jessica L Bridgford, Eva S Istvan

Cell Chem Biol· May 2022

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Prioritization of Molecular Targets for Antimalarial Drug Discovery.
Barbara Forte, Sabine Ottilie, Andrew Plater, Brice Campo, Koen J Dechering, Eva S Istvan

ACS Infect Dis· October 2021

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MalDA, Accelerating Malaria Drug Discovery.
Tuo Yang, Sabine Ottilie, Eva S Istvan, Karla P Godinez-Macias, Amanda K Lukens

Trends Parasitol· June 2021

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PfMFR3: A Multidrug-Resistant Modulator in .
Frances Rocamora, Purva Gupta, Eva S Istvan, Madeline R Luth, Emma F Carpenter

ACS Infect Dis· April 2021

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Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box.
Janette Reader, Mariëtte E van der Watt, Dale Taylor, Claire Le Manach, Nimisha Mittal, Eva S Istvan

Nat Commun· January 2021

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Contacting domains segregate a lipid transporter from a solute transporter in the malarial host-parasite interface.
Matthias Garten, Josh R Beck, Robyn Roth, Tatyana Tenkova-Heuser, John Heuser, Eva S Istvan

Nat Commun· July 2020

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Malaria parasite plasmepsins: More than just plain old degradative pepsins.
Armiyaw S Nasamu, Alexander J Polino, Eva S Istvan, Daniel E Goldberg

J Biol Chem· June 2020

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Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery.
James M Murithi, Edward S Owen, Eva S Istvan, Marcus C S Lee, Sabine Ottilie

Cell Chem Biol· February 2020

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Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis.
Eva S Istvan, Sudipta Das, Suyash Bhatnagar, Josh R Beck, Edward Owen

Elife· March 2019

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Development of piperazine-based hydroxamic acid inhibitors against falcilysin, an essential malarial protease.
Jeffrey P Chance, Hannah Fejzic, Obiel Hernandez, Eva S Istvan, Armann Andaya

Bioorg Med Chem Lett· June 2018

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Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.
Annie N Cowell, Eva S Istvan, Amanda K Lukens, Maria G Gomez-Lorenzo, Manu Vanaerschot

Science· January 2018

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Esterase mutation is a mechanism of resistance to antimalarial compounds.
Eva S Istvan, Jeremy P Mallari, Victoria C Corey, Neekesh V Dharia, Garland R Marshall

Nat Commun· January 2017

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A broad analysis of resistance development in the malaria parasite.
Victoria C Corey, Amanda K Lukens, Eva S Istvan, Marcus C S Lee, Virginia Franco

Nat Commun· June 2016

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Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state.
Shalon E Babbitt, Lindsey Altenhofen, Simon A Cobbold, Eva S Istvan, Clare Fennell

Proc Natl Acad Sci U S A· November 2012

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Validation of isoleucine utilization targets in Plasmodium falciparum.
Eva S Istvan, Neekesh V Dharia, Selina E Bopp, Ilya Gluzman, Elizabeth A Winzeler

Proc Natl Acad Sci U S A· January 2011

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Safety and efficacy of nateglinide/metformin combination therapy in the treatment of type 2 diabetes.
Marc K Israel, Eva Istvan, Michelle A Baron

Vasc Health Risk Manag· April 2009

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Hemoglobin-degrading plasmepsin II is active as a monomer.
Jun Liu, Eva S Istvan, Daniel E Goldberg

J Biol Chem· December 2006

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