Publications by authors named "Gary Karp"

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Ribonucleotide reductase, a novel drug target for gonorrhea.
Jana Narasimhan, Suzanne Letinski, Stephen P Jung, Aleksey Gerasyuto, Jiashi Wang, Gary Karp

Elife· February 2022

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Small molecule splicing modifiers with systemic HTT-lowering activity.
Anuradha Bhattacharyya, Christopher R Trotta, Jana Narasimhan, Kari J Wiedinger, Wencheng Li, Gary M Karp

Nat Commun· December 2021

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A deep learning approach to identify gene targets of a therapeutic for human splicing disorders.
Dadi Gao, Elisabetta Morini, Monica Salani, Aram J Krauson, Anil Chekuri, Gary Karp

Nat Commun· June 2021

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Corrigendum to: Pharmacologically-induced mouse model of adult spinal muscular atrophy to evaluate effectiveness of therapeutics after disease onset.
Zhihua Feng, Karen K Y Ling, Xin Zhao, Chunyi Zhou, Gary Karp

Hum Mol Genet· May 2021

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Correction to Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-Negative Bacteria.
Aleksey I Gerasyuto, Michael A Arnold, Jiashi Wang, Guangming Chen, Xiaoyan Zhang, Gary M Karp

J Med Chem· October 2018

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Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-Pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-negative Bacteria.
Aleksey I Gerasyuto, Michael A Arnold, Jiashi Wang, Guangming Chen, Xiaoyan Zhang, Gary M Karp

J Med Chem· May 2018

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4-Hydroxy-2-pyridones: Discovery and evaluation of a novel class of antibacterial agents targeting DNA synthesis.
Michael A Arnold, Aleksey I Gerasyuto, Jiashi Wang, Wu Du, Yi Jin Kim Gorske, Gary M Karp

Bioorg Med Chem Lett· November 2017

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Identification of benzazole compounds that induce HIV-1 transcription.
Jason D Graci, Daniel Michaels, Guangming Chen, Gillian M Schiralli Lester, Sarah Nodder, Gary M Karp

PLoS One· September 2017

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Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy.
Hasane Ratni, Gary M Karp, Marla Weetall, Nikolai A Naryshkin, Sergey V Paushkin

J Med Chem· July 2016

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Discovery and Optimization of Small Molecule Splicing Modifiers of Survival Motor Neuron 2 as a Treatment for Spinal Muscular Atrophy.
Matthew G Woll, Hongyan Qi, Anthony Turpoff, Nanjing Zhang, Xiaoyan Zhang, Gary M Karp

J Med Chem· July 2016

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Pharmacokinetics, pharmacodynamics, and efficacy of a small-molecule SMN2 splicing modifier in mouse models of spinal muscular atrophy.
Xin Zhao, Zhihua Feng, Karen K Y Ling, Anna Mollin, Josephine Sheedy, Gary Karp

Hum Mol Genet· May 2016

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Pharmacologically induced mouse model of adult spinal muscular atrophy to evaluate effectiveness of therapeutics after disease onset.
Zhihua Feng, Karen K Y Ling, Xin Zhao, Chunyi Zhou, Gary Karp

Hum Mol Genet· March 2016

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Discovery of 2-(4-sulfonamidophenyl)-indole 3-carboxamides as potent and selective inhibitors with broad hepatitis C virus genotype activity targeting HCV NS4B.
Nanjing Zhang, Anthony Turpoff, Xiaoyan Zhang, Song Huang, Yalei Liu, Gary M Karp

Bioorg Med Chem Lett· January 2016

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6-(Azaindol-2-yl)pyridine-3-sulfonamides as potent and selective inhibitors targeting hepatitis C virus NS4B.
Guangming Chen, Hongyu Ren, Nanjing Zhang, William Lennox, Anthony Turpoff, Gary M Karp

Bioorg Med Chem Lett· February 2015

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Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy.
Nikolai A Naryshkin, Marla Weetall, Amal Dakka, Jana Narasimhan, Xin Zhao, Gary M Karp

Science· August 2014

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Structure-activity relationship (SAR) optimization of 6-(indol-2-yl)pyridine-3-sulfonamides: identification of potent, selective, and orally bioavailable small molecules targeting hepatitis C (HCV) NS4B.
Nanjing Zhang, Xiaoyan Zhang, Jin Zhu, Anthony Turpoff, Guangming Chen, Gary M Karp

J Med Chem· March 2014

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Identification of PTC725, an orally bioavailable small molecule that selectively targets the hepatitis C Virus NS4B protein.
Zhengxian Gu, Jason D Graci, Frederick C Lahser, Jamie J Breslin, Stephen P Jung, Gary Karp

Antimicrob Agents Chemother· July 2013

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Discovery of N-(4'-(indol-2-yl)phenyl)sulfonamides as novel inhibitors of HCV replication.
Guangming Chen, Hongyu Ren, Anthony Turpoff, Alexander Arefolov, Richard Wilde, Gary M Karp

Bioorg Med Chem Lett· July 2013

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Discovery of novel HCV inhibitors: synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B.
Xiaoyan Zhang, Nanjing Zhang, Guangming Chen, Anthony Turpoff, Hongyu Ren, Gary M Karp

Bioorg Med Chem Lett· July 2013

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PTC124 targets genetic disorders caused by nonsense mutations.
Ellen M Welch, Elisabeth R Barton, Jin Zhuo, Yuki Tomizawa, Westley J Friesen, Gary Karp

Nature· May 2007

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An Expeditious Route to Novel 1,4,2-Benzodiazaphosphepin-5-one 2-Oxide Analogues.
Gary M. Karp

J Org Chem· October 1999

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