Publications by authors named "George Scheffer"

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PD-L1 directed bispecific Vδ2-T cell engager combines lysis of PD-L1 expressing tumor cells with PD-1 immune checkpoint inhibition and modulation of the tumor immune microenvironment.
Lisa A King, Myrthe Veth, Marieke Roos, George L Scheffer, Marko A Popovic

J Immunother Cancer· October 2025

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A Bispecific Antibody Antagonizes Prosurvival CD40 Signaling and Promotes Vγ9Vδ2 T cell-Mediated Antitumor Responses in Human B-cell Malignancies.
Iris de Weerdt, Roeland Lameris, George L Scheffer, Jana Vree, Renate de Boer

Cancer Immunol Res· January 2021

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Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide.
Ruud Oerlemans, Celia R Berkers, Yehuda G Assaraf, George L Scheffer, Godefridus J Peters

Invest New Drugs· October 2018

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Novel Stool-Based Protein Biomarkers for Improved Colorectal Cancer Screening: A Case-Control Study.
Linda J W Bosch, Meike de Wit, Thang V Pham, Veerle M H Coupé, Annemieke C Hiemstra, George L Scheffer

Ann Intern Med· December 2017

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Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR.
Sue Ellen Verbrugge, Marjon Al, Yehuda G Assaraf, Sarah Kammerer, Durga M S H Chandrupatla, George L Scheffer

Oncotarget· February 2016

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Sensing of latent EBV infection through exosomal transfer of 5'pppRNA.
S Rubina Baglio, Monique A J van Eijndhoven, Danijela Koppers-Lalic, Jordi Berenguer, Sinéad M Lougheed, George L Scheffer

Proc Natl Acad Sci U S A· February 2016

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The EGFR pathway regulates BCRP expression in NSCLC cells: role of erlotinib.
Letizia Porcelli, Elisa Giovannetti, Yehuda G Assaraf, Gerrit Jansen, George L Scheffer

Curr Drug Targets· August 2015

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Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine.
Auke D Adema, Karijn Floor, Kees Smid, Richard J Honeywell, George L Scheffer

Springerplus· February 2015

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Control of metazoan heme homeostasis by a conserved multidrug resistance protein.
Tamara Korolnek, Jianbing Zhang, Simon Beardsley, George L Scheffer, Iqbal Hamza

Cell Metab· June 2014

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Expression levels of the ABCG2 multidrug transporter in human erythrocytes correspond to pharmacologically relevant genetic variations.
Ildikó Kasza, György Várady, Hajnalka Andrikovics, Magdalena Koszarska, Attila Tordai, George L Scheffer

PLoS One· May 2013

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Overcoming bortezomib resistance in human B cells by anti-CD20/rituximab-mediated complement-dependent cytotoxicity and epoxyketone-based irreversible proteasome inhibitors.
Sue Ellen Verbrugge, Marjon Al, Yehuda G Assaraf, Denise Niewerth, Johan van Meerloo, George L Scheffer

Exp Hematol Oncol· January 2013

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ABCC5 supports osteoclast formation and promotes breast cancer metastasis to bone.
Anna A Mourskaia, Eitan Amir, Zhifeng Dong, Kerstin Tiedemann, Sean Cory, George L Scheffer

Breast Cancer Res· November 2012

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Altered arsenic disposition in experimental nonalcoholic fatty liver disease.
Mark J Canet, Rhiannon N Hardwick, April D Lake, Michael J Kopplin, George L Scheffer

Drug Metab Dispos· September 2012

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Inactivating PSMB5 mutations and P-glycoprotein (multidrug resistance-associated protein/ATP-binding cassette B1) mediate resistance to proteasome inhibitors: ex vivo efficacy of (immuno)proteasome inhibitors in mononuclear blood cells from patients with rheumatoid arthritis.
Sue Ellen Verbrugge, Yehuda G Assaraf, Ben A C Dijkmans, George L Scheffer, Marjon Al

J Pharmacol Exp Ther· April 2012

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Preferential Langerhans cell differentiation from CD34(+) precursors upon introduction of ABCG2 (BCRP).
Rieneke van de Ven, Jelle J Lindenberg, Anneke W Reurs, Rik J Scheper, George L Scheffer

Immunol Cell Biol· February 2012

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Exposure of CD34+ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy.
Rieneke van de Ven, Anneke W Reurs, Pepijn G J T B Wijnands, Sandra van Wetering, Ada M Kruisbeek, George L Scheffer

Cancer Immunol Immunother· February 2012

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Variations in ATP-binding cassette transporter regulation during the progression of human nonalcoholic fatty liver disease.
Rhiannon N Hardwick, Craig D Fisher, Mark J Canet, George L Scheffer, Nathan J Cherrington

Drug Metab Dispos· December 2011

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High susceptibility of c-KIT+CD34+ precursors to prolonged doxorubicin exposure interferes with Langerhans cell differentiation in a human cell line model.
Rieneke van de Ven, Sue Ellen Verbrugge, Anneke W Reurs, Hetty J Bontkes, Erik Hooijberg, George L Scheffer

Cancer Immunol Immunother· July 2011

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Adenosine triphosphate-binding cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes: relevance to multiple sclerosis pathogenesis.
Gijs Kooij, Mark R Mizee, Jack van Horssen, Arie Reijerkerk, Maarten E Witte, George Scheffer

Brain· February 2011

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Impact of ABCG2 polymorphisms on the clinical outcome and toxicity of gefitinib in non-small-cell lung cancer patients.
Clara Lemos, Elisa Giovannetti, Paolo A Zucali, Yehuda G Assaraf, George L Scheffer

Pharmacogenomics· February 2011

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Protease inhibitors atazanavir, lopinavir and ritonavir are potent blockers, but poor substrates, of ABC transporters in a broad panel of ABC transporter-overexpressing cell lines.
Wouter F W Bierman, George L Scheffer, Antoinet Schoonderwoerd, Gerrit Jansen, Michiel A van Agtmael

J Antimicrob Chemother· August 2010

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T lymphocytes impair P-glycoprotein function during neuroinflammation.
Gijs Kooij, Jack van Horssen, Elizabeth C M de Lange, Arie Reijerkerk, Susanne M A van der Pol, George Scheffer

J Autoimmun· June 2010

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Selective transduction of mature DC in human skin and lymph nodes by CD80/CD86-targeted fiber-modified adenovirus-5/3.
Rieneke van de Ven, Jelle J Lindenberg, Dinja Oosterhoff, M Petrousjka van den Tol, Rodney A Rosalia, George L Scheffer

J Immunother· January 2010

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ABC drug transporters and immunity: novel therapeutic targets in autoimmunity and cancer.
Rieneke van de Ven, Ruud Oerlemans, Joost W van der Heijden, George L Scheffer, Tanja D de Gruijl

J Leukoc Biol· November 2009

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The ABC of dendritic cell development and function.
Rieneke van de Ven, George L Scheffer, Rik J Scheper, Tanja D de Gruijl

Trends Immunol· September 2009

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