Publications by authors named "Gerald Brosch"

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A toolbox for class I HDACs reveals isoform specific roles in gene regulation and protein acetylation.
Lena Hess, Verena Moos, Arnel A Lauber, Wolfgang Reiter, Michael Schuster, Gerald Brosch

PLoS Genet· August 2022

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Novel Pyridine-Based Hydroxamates and 2'-Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activity.
Clemens Zwergel, Elisabetta Di Bello, Rossella Fioravanti, Mariarosaria Conte, Angela Nebbioso, Gerald Brosch

ChemMedChem· March 2021

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RcLS2F - A Novel Fungal Class 1 KDAC Co-repressor Complex in .
Ingo Bauer, Silke Gross, Petra Merschak, Leopold Kremser, Betim Karahoda, Gerald Brosch

Front Microbiol· February 2020

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Type I and II PRMTs regulate catabolic as well as detoxifying processes in Aspergillus nidulans.
Ingo Bauer, Lukas Lechner, Angelo Pidroni, Anna-Maria Petrone, Petra Merschak, Gerald Brosch

Fungal Genet Biol· August 2019

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Single-Step Enrichment of a TAP-Tagged Histone Deacetylase of the Filamentous Fungus Aspergillus nidulans for Enzymatic Activity Assay.
Ingo Bauer, Angelo Pidroni, Özgür Bayram, Gerald Brosch, Stefan Graessle

J Vis Exp· May 2019

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A Class 1 Histone Deacetylase as Major Regulator of Secondary Metabolite Production in .
Angelo Pidroni, Birgit Faber, Gerald Brosch, Ingo Bauer, Stefan Graessle

Front Microbiol· September 2018

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A Class 1 Histone Deacetylase with Potential as an Antifungal Target.
Ingo Bauer, Divyavaradhi Varadarajan, Angelo Pidroni, Silke Gross, Stefan Vergeiner, Gerald Brosch

mBio· November 2016

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2-Benzazolyl-4-Piperazin-1-Ylsulfonylbenzenecarbohydroxamic Acids as Novel Selective Histone Deacetylase-6 Inhibitors with Antiproliferative Activity.
Lei Wang, Marina Kofler, Gerald Brosch, Jelena Melesina, Wolfgang Sippl

PLoS One· July 2016

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AmcA-a putative mitochondrial ornithine transporter supporting fungal siderophore biosynthesis.
Lukas Schafferer, Nicola Beckmann, Ulrike Binder, Gerald Brosch, Hubertus Haas

Front Microbiol· April 2015

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1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells.
Sergio Valente, Daniela Trisciuoglio, Teresa De Luca, Angela Nebbioso, Donatella Labella, Gerald Brosch

J Med Chem· July 2014

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A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog.
Astrid Hagelkruys, Sabine Lagger, Julia Krahmer, Alexandra Leopoldi, Matthias Artaker, Gerald Brosch

Development· February 2014

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Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis.
Mircea Winter, Mirjam A Moser, Dominique Meunier, Carina Fischer, Georg Machat, Gerald Brosch

EMBO J· December 2013

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Novel cinnamyl hydroxyamides and 2-aminoanilides as histone deacetylase inhibitors: apoptotic induction and cytodifferentiation activity.
Sergio Valente, Maria Tardugno, Mariarosaria Conte, Roberto Cirilli, Andrea Perrone, Gerald Brosch

ChemMedChem· April 2011

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Novel insights into the functional role of three protein arginine methyltransferases in Aspergillus nidulans.
Ingo Bauer, Stefan Graessle, Peter Loidl, Kurt Hohenstein, Gerald Brosch

Fungal Genet Biol· June 2010

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Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1).
Sabrina Castellano, Ciro Milite, Rino Ragno, Silvia Simeoni, Antonello Mai, Gerald Brosch

ChemMedChem· March 2010

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A novel motif in fungal class 1 histone deacetylases is essential for growth and development of Aspergillus.
Martin Tribus, Ingo Bauer, Johannes Galehr, Gudrun Rieser, Patrick Trojer, Gerald Brosch

Mol Biol Cell· January 2010

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New pyrrole-based histone deacetylase inhibitors: binding mode, enzyme- and cell-based investigations.
Antonello Mai, Sergio Valente, Angela Nebbioso, Silvia Simeoni, Rino Ragno, Gerald Brosch

Int J Biochem Cell Biol· January 2009

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Histone modifications and chromatin dynamics: a focus on filamentous fungi.
Gerald Brosch, Peter Loidl, Stefan Graessle

FEMS Microbiol Rev· May 2008

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epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors.
Antonello Mai, Donghang Cheng, Mark T Bedford, Sergio Valente, Angela Nebbioso, Gerald Brosch

J Med Chem· April 2008

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Class II-selective histone deacetylase inhibitors. Part 2: alignment-independent GRIND 3-D QSAR, homology and docking studies.
Rino Ragno, Silvia Simeoni, Dante Rotili, Antonella Caroli, Giorgia Botta, Gerald Brosch

Eur J Med Chem· March 2008

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Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia.
Antonello Mai, Katija Jelicic, Dante Rotili, Antonella Di Noia, Elena Alfani, Gerald Brosch

Mol Pharmacol· November 2007

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Novel pyrrole-containing histone deacetylase inhibitors endowed with cytodifferentiation activity.
Antonello Mai, Sergio Valente, Dante Rotili, Silvio Massa, Giorgia Botta, Gerald Brosch

Int J Biochem Cell Biol· October 2007

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A novel arginine methyltransferase inhibitor with cellular activity.
Astrid Spannhoff, Rospita Machmur, Ralf Heinke, Patrick Trojer, Ingo Bauer, Gerald Brosch

Bioorg Med Chem Lett· August 2007

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Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors.
Antonello Mai, Sergio Valente, Donghang Cheng, Andrea Perrone, Rino Ragno, Gerald Brosch

ChemMedChem· July 2007

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Target-based approach to inhibitors of histone arginine methyltransferases.
Astrid Spannhoff, Ralf Heinke, Ingo Bauer, Patrick Trojer, Eric Metzger, Gerald Brosch

J Med Chem· May 2007

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