Publications by authors named "Graham A Heap"

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Pharmacological Characterization of Zasocitinib (TAK-279): An Oral, Highly Selective, and Potent Allosteric TYK2 Inhibitor.
Shailly Mehrotra, Yasuyo Sano, Petro Halkowycz, Elizabeth Wilson, Chandra Durairaj, Graham A Heap

J Invest Dermatol· January 2026

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A stacking ensemble machine learning model to predict alpha-1 antitrypsin deficiency-associated liver disease clinical outcomes based on UK Biobank data.
Linxi Meng, Will Treem, Graham A Heap, Jingjing Chen

Sci Rep· October 2022

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Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility.
Aleksejs Sazonovs, Christine R Stevens, Guhan R Venkataraman, Kai Yuan, Brandon Avila, Graham A Heap

Nat Genet· September 2022

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Clinical Features and Genetic Risk of Demyelination Following Anti-TNF Treatment.
Simeng Lin, Harry D Green, Peter Hendy, Neel M Heerasing, Neil Chanchlani, Graham A Heap

J Crohns Colitis· December 2020

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HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease.
Aleksejs Sazonovs, Nicholas A Kennedy, Loukas Moutsianas, Graham A Heap, Daniel L Rice

Gastroenterology· January 2020

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Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study.
Nicholas A Kennedy, Graham A Heap, Harry D Green, Benjamin Hamilton, Claire Bewshea

Lancet Gastroenterol Hepatol· May 2019

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Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease.
Gareth J Walker, James W Harrison, Graham A Heap, Michiel D Voskuil, Vibeke Andersen

JAMA· February 2019

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Corrigendum: Clinical Features and HLA Association of 5-Aminosalicylate (5-ASA)-induced Nephrotoxicity in Inflammatory Bowel Disease.
Graham A Heap, Kenji So, Mike Weedon, Naomi Edney, Claire Bewshea

J Crohns Colitis· December 2017

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Erratum: A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.
Manuel A Rivas, Daniel Graham, Patrick Sulem, Christine Stevens, A Nicole Desch, Graham A Heap

Nat Commun· September 2016

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A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.
Manuel A Rivas, Daniel Graham, Patrick Sulem, Christine Stevens, A Nicole Desch, Graham A Heap

Nat Commun· August 2016

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The immunogenicity of biosimilar infliximab: can we extrapolate the data across indications?
Shomron Ben-Horin, Graham A Heap, Tariq Ahmad, HoUng Kim, TaekSang Kwon

Expert Rev Gastroenterol Hepatol· July 2016

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Clinical Features and HLA Association of 5-Aminosalicylate (5-ASA)-induced Nephrotoxicity in Inflammatory Bowel Disease.
Graham A Heap, Kenji So, Mike Weedon, Naomi Edney, Claire Bewshea

J Crohns Colitis· February 2016

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HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants.
Graham A Heap, Michael N Weedon, Claire M Bewshea, Abhey Singh, Mian Chen

Nat Genet· October 2014

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Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry.
Karen A Hunt, Deborah J Smyth, Tobias Balschun, Maria Ban, Vanisha Mistry, Graham A R Heap

Nat Genet· December 2011

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Comparative methylomics reveals gene-body H3K36me3 in Drosophila predicts DNA methylation and CpG landscapes in other invertebrates.
Lisa Nanty, Guillermo Carbajosa, Graham A Heap, Francis Ratnieks, David A van Heel

Genome Res· November 2011

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Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease.
Gosia Trynka, Karen A Hunt, Nicholas A Bockett, Jihane Romanos, Vanisha Mistry, Graham A R Heap

Nat Genet· November 2011

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Multiple common variants for celiac disease influencing immune gene expression.
Patrick C A Dubois, Gosia Trynka, Lude Franke, Karen A Hunt, Jihane Romanos, Graham A R Heap

Nat Genet· April 2010

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Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing.
Graham A Heap, Jennie H M Yang, Kate Downes, Barry C Healy, Karen A Hunt

Hum Mol Genet· January 2010

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Genetics and pathogenesis of coeliac disease.
Graham A Heap, David A van Heel

Semin Immunol· December 2009

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The genetics of chronic inflammatory diseases.
Graham A Heap, David A van Heel

Hum Mol Genet· April 2009

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Association study of the IL18RAP locus in three European populations with coeliac disease.
Lotta L E Koskinen, Elisabet Einarsdottir, Emma Dukes, Graham A R Heap, Patrick Dubois

Hum Mol Genet· March 2009

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Complex nature of SNP genotype effects on gene expression in primary human leucocytes.
Graham A Heap, Gosia Trynka, Ritsert C Jansen, Marcel Bruinenberg, Morris A Swertz

BMC Med Genomics· January 2009

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Shared and distinct genetic variants in type 1 diabetes and celiac disease.
Deborah J Smyth, Vincent Plagnol, Neil M Walker, Jason D Cooper, Kate Downes, Graham A Heap

N Engl J Med· December 2008

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Newly identified genetic risk variants for celiac disease related to the immune response.
Karen A Hunt, Alexandra Zhernakova, Graham Turner, Graham A R Heap, Lude Franke

Nat Genet· April 2008

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