Publications by authors named "Graham Packham"

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Exploring 2-Sulfonylpyrimidine Warheads as Acrylamide Surrogates for Targeted Covalent Inhibition: A BTK Story.
Ruxandra Moraru, Beatriz Valle-Argos, Annabel Minton, Lara Buermann, Suyin Pan, Graham Packham

J Med Chem· August 2024

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Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL.
Dean Bryant, Lindsay Smith, Karly Rai Rogers-Broadway, Laura Karydis, Jeongmin Woo, Graham Packham

Leukemia· July 2023

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Characterization of metabolic alterations of chronic lymphocytic leukemia in the lymph node microenvironment.
Zhenghao Chen, Helga Simon-Molas, Gaspard Cretenet, Beatriz Valle-Argos, Lindsay D Smith, Graham Packham

Blood· August 2022

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BTK-independent regulation of calcium signalling downstream of the B-cell receptor in malignant B-cells.
Rachael Arthur, Alexander Wathen, Elizabeth A Lemm, Freda K Stevenson, Francesco Forconi, Graham Packham

Cell Signal· August 2022

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B-cell receptor signaling induces proteasomal degradation of PDCD4 via MEK1/2 and mTORC1 in malignant B cells.
Joe Taylor, Sarah Wilmore, Sophie Marriot, Karly-Rai Rogers-Broadway, Rachel Fell, Graham Packham

Cell Signal· June 2022

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Editor's Note: miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance.
Lei Zhang, Karen Pickard, Veronika Jenei, Marc D Bullock, Amanda Bruce, Graham Packham

Cancer Res· April 2022

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B-cell receptor dependent phagocytosis and presentation of particulate antigen by chronic lymphocytic leukemia cells.
Annabel R Minton, Lindsay D Smith, Dean J Bryant, Jonathan C Strefford, Francesco Forconi, Graham Packham

Explor Target Antitumor Ther· February 2022

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Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy within Primary CLL Cells.
Adam J Linley, Laura I Karydis, Anil K Mondru, Annalisa D'Avola, Humood Al Shmrany, Graham Packham

Clin Cancer Res· October 2021

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Insertion of atypical glycans into the tumor antigen-binding site identifies DLBCLs with distinct origin and behavior.
Giorgia Chiodin, Joel D Allen, Dean J Bryant, Philip Rock, Enrica A Martino, Graham Packham

Blood· October 2021

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Targeted inhibition of eIF4A suppresses B-cell receptor-induced translation and expression of MYC and MCL1 in chronic lymphocytic leukemia cells.
Sarah Wilmore, Karly-Rai Rogers-Broadway, Joe Taylor, Elizabeth Lemm, Rachel Fell, Graham Packham

Cell Mol Life Sci· September 2021

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KDM5 inhibition offers a novel therapeutic strategy for the treatment of KMT2D mutant lymphomas.
James Heward, Lola Konali, Annalisa D'Avola, Karina Close, Alison Yeomans, Graham Packham

Blood· August 2021

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DC-SIGN binding to mannosylated B-cell receptors in follicular lymphoma down-modulates receptor signaling capacity.
Beatriz Valle-Argos, Giorgia Chiodin, Dean J Bryant, Joe Taylor, Elizabeth Lemm, Graham Packham

Sci Rep· June 2021

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Synthesis of Carboxamide-Containing Tranylcypromine Analogues as LSD1 (KDM1A) Inhibitors Targeting Acute Myeloid Leukemia.
Maria Teresa Borrello, Hanae Benelkebir, Adam Lee, Chak Hin Tam, Manar Shafat, Graham Packham

ChemMedChem· April 2021

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V-ATPase Inhibition Decreases Mutant Androgen Receptor Activity in Castrate-resistant Prostate Cancer.
Bradleigh Whitton, Haruko Okamoto, Matthew Rose-Zerilli, Graham Packham, Simon J Crabb

Mol Cancer Ther· April 2021

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Upregulation of epithelial metallothioneins by metal-rich ultrafine particulate matter from an underground railway.
Matthew Loxham, Jeongmin Woo, Akul Singhania, Natalie P Smithers, Alison Yeomans, Graham Packham

Metallomics· July 2020

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BET inhibitors synergize with venetoclax to induce apoptosis in MYC-driven lymphomas with high BCL-2 expression.
Thomas E C Cummin, Kerry L Cox, Tom D Murray, Anna H Turaj, Lisa Dunning, Graham Packham

Blood Adv· July 2020

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Correction: Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter's syndrome: therapeutic implications.
Francesca Arruga, Valeria Bracciamà, Nicoletta Vitale, Tiziana Vaisitti, Katiuscia Gizzi, Graham Packham

Leukemia· June 2020

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Development of PROTACs to address clinical limitations associated with BTK-targeted kinase inhibitors.
Rachael Arthur, Beatriz Valle-Argos, Andrew J Steele, Graham Packham

Explor Target Antitumor Ther· June 2020

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Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells.
Elizabeth A Lemm, Beatriz Valle-Argos, Lindsay D Smith, Johanna Richter, Yohannes Gebreselassie, Graham Packham

Clin Cancer Res· April 2020

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BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia.
Lindsay D Smith, Annabel R Minton, Matthew D Blunt, Laura I Karydis, David A Dutton, Graham Packham

Leukemia· February 2020

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Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter's syndrome: therapeutic implications.
Francesca Arruga, Valeria Bracciamà, Nicoletta Vitale, Tiziana Vaisitti, Katiuscia Gizzi, Graham Packham

Leukemia· February 2020

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Exploration of Targeted Anti-tumor Therapy: a contribution to the development of targeted therapies.
Nicola Normanno, Graham Packham

Explor Target Antitumor Ther· February 2020

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Targeted inhibition of mRNA translation initiation factors as a novel therapeutic strategy for mature B-cell neoplasms.
Joe Taylor, Alison M Yeomans, Graham Packham

Explor Target Antitumor Ther· February 2020

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Ibrutinib Therapy Releases Leukemic Surface IgM from Antigen Drive in Chronic Lymphocytic Leukemia Patients.
Samantha Drennan, Giorgia Chiodin, Annalisa D'Avola, Ian Tracy, Peter W Johnson, Graham Packham

Clin Cancer Res· April 2019

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CD40L/IL-4-stimulated CLL demonstrates variation in translational regulation of DNA damage response genes including ATM.
Larissa Lezina, Ruth V Spriggs, Daniel Beck, Carolyn Jones, Kate M Dudek, Graham Packham

Blood Adv· August 2018

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