Publications by authors named "Heidi Welch"

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P-Rex1 limits glucose clearance and suppresses hepatocyte glucose uptake and mitochondrial metabolism independently of its Rac-GEF activity.
Julia Y Chu, Elpida Tsonou, Polly A Machin, Kirsty MacLellan-Gibson, Anna G Roberts, Heidi C E Welch

Cell Rep· October 2025

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P-Rex1 controls phagocytosis and the killing of bacteria by murine neutrophils independently of its catalytic activity.
Priota Islam, Julia Y Chu, Stephen A Chetwynd, Rachael Walker, Phillip T Hawkins, Heidi C E Welch

Front Immunol· October 2025

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P-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activity.
Martin J Baker, Elizabeth Hampson, Priota Islam, Ruben Pelaez Moral, Eve A Maunders, Heidi C E Welch

Cell Rep· October 2025

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P-Rex2 suppresses glucose uptake into liver and skeletal muscle through different adaptor functions.
Elpida Tsonou, Julia Y Chu, Polly A Machin, Anna G Roberts, Anne Segonds-Pichon, Heidi C E Welch

Sci Rep· August 2025

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Aspirin prevents metastasis by limiting platelet TXA suppression of T cell immunity.
Jie Yang, Yumi Yamashita-Kanemaru, Benjamin I Morris, Annalisa Contursi, Daniel Trajkovski, Heidi C E Welch

Nature· April 2025

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Targeting the PREX2/RAC1/PI3Kβ Signaling Axis Confers Sensitivity to Clinically Relevant Therapeutic Approaches in Melanoma.
Catriona A Ford, Dana Koludrovic, Patricia P Centeno, Mona Foth, Elpida Tsonou, Heidi C E Welch

Cancer Res· February 2025

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The GPCR adaptor protein Norbin controls the trafficking of C5aR1 and CXCR4 in mouse neutrophils.
Stephen A Chetwynd, Richard J Ward, Graeme Milligan, Heidi C E Welch

J Biol Chem· December 2024

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The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses.
Kirsti Hornigold, Martin J Baker, Polly A Machin, Stephen A Chetwynd, Anna-Karin Johnsson, Heidi C E Welch

Front Immunol· December 2023

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Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis.
Polly A Machin, Anna-Karin E Johnsson, Ellie J Massey, Chiara Pantarelli, Stephen A Chetwynd, Heidi C E Welch

Front Immunol· October 2023

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The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells.
Valdemar B I Johansen, Elizabeth Hampson, Elpida Tsonou, Chiara Pantarelli, Julia Y Chu, Heidi C E Welch

Sci Rep· October 2023

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Functions and mechanisms of the GPCR adaptor protein Norbin.
Stephen A Chetwynd, Simon Andrews, Sarah Inglesfield, Christine Delon, Nicholas T Ktistakis, Heidi C E Welch

Biochem Soc Trans· August 2023

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Characterization of BNT162b2 mRNA to Evaluate Risk of Off-Target Antigen Translation.
Himakshi K Patel, Kun Zhang, Rachael Utegg, Elaine Stephens, Shauna Salem, Heidi Welch

J Pharm Sci· May 2023

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Age-related decline in the resistance of mice to bacterial infection and in LPS/TLR4 pathway-dependent neutrophil responses.
Kirsti Hornigold, Julia Y Chu, Stephen A Chetwynd, Polly A Machin, Laraine Crossland, Heidi C E Welch

Front Immunol· September 2022

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Behavioural immune landscapes of inflammation.
Georgiana Crainiciuc, Miguel Palomino-Segura, Miguel Molina-Moreno, Jon Sicilia, David G Aragones, Heidi C E Welch

Nature· January 2022

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Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging.
Alessia Floerchinger, Kendelle J Murphy, Sharissa L Latham, Sean C Warren, Andrew T McCulloch, Heidi C E Welch

Cell Rep· September 2021

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P-Rex1 Controls Sphingosine 1-Phosphate Receptor Signalling, Morphology, and Cell-Cycle Progression in Neuronal Cells.
Elizabeth Hampson, Elpida Tsonou, Martin J Baker, David C Hornigold, Roderick E Hubbard, Heidi C E Welch

Cells· September 2021

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The GPCR adaptor protein norbin suppresses the neutrophil-mediated immunity of mice to pneumococcal infection.
Chiara Pantarelli, Dingxin Pan, Stephen Chetwynd, Anne-Katrien Stark, Kirsti Hornigold, Heidi C E Welch

Blood Adv· August 2021

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Rho Family GTPases and Rho GEFs in Glucose Homeostasis.
Polly A Machin, Elpida Tsonou, David C Hornigold, Heidi C E Welch

Cells· April 2021

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PtdIns(3,4,5)P-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis.
Nuthasuda Srijakotre, Heng-Jia Liu, Max Nobis, Joey Man, Hon Yan Kelvin Yip, Heidi C E Welch

Proc Natl Acad Sci U S A· November 2020

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Rac-GTPases and Rac-GEFs in neutrophil adhesion, migration and recruitment.
Chiara Pantarelli, Heidi C E Welch

Eur J Clin Invest· November 2018

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Removing physiological motion from intravital and clinical functional imaging data.
Sean C Warren, Max Nobis, Astrid Magenau, Yousuf H Mohammed, David Herrmann, Heidi Ce Welch

Elife· July 2018

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A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.
Max Nobis, David Herrmann, Sean C Warren, Shereen Kadir, Wilfred Leung, Heidi C E Welch

Cell Rep· October 2017

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Platelets in neutrophil recruitment to sites of inflammation.
Simon Pitchford, Dingxin Pan, Heidi C E Welch

Curr Opin Hematol· January 2017

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Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1.
Dingxin Pan, Mark A Barber, Kirsti Hornigold, Martin J Baker, Judit M Toth, Heidi C E Welch

J Biol Chem· March 2016

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Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma.
Yonathan Lissanu Deribe, Yanxia Shi, Kunal Rai, Luigi Nezi, Samir B Amin, Heidi C E Welch

Proc Natl Acad Sci U S A· March 2016

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