Publications by authors named "Helmut Sparrer"

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Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors.
Ralf Glatthar, Aleksandar Stojanovic, Thomas Troxler, Henri Mattes, Henrik Möbitz, Helmut Sparrer

J Med Chem· August 2016

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The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold.
Sascha Gutmann, Alexandra Hinniger, Gabriele Fendrich, Peter Drückes, Sylvie Antz, Helmut Sparrer

J Biol Chem· June 2015

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MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice.
Dov B Ballak, Peter van Essen, Janna A van Diepen, Henry Jansen, Anneke Hijmans, Helmut Sparrer

PLoS One· March 2015

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NMR-Based Strategies to Elucidate Bioactive Conformations of Weakly Binding Ligands.
Marcel J J Blommers, Andre Strauss, Martin Geiser, Paul Ramage, Helmut Sparrer

Top Curr Chem· April 2013

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Bleomycin-induced lung injury in mice investigated by MRI: model assessment for target analysis.
Anna L Babin, Catherine Cannet, Christelle Gérard, Pierre Saint-Mezard, Clive P Page, Helmut Sparrer

Magn Reson Med· February 2012

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Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta.
Leo A B Joosten, Mihai G Netea, Giamila Fantuzzi, Marije I Koenders, Monique M A Helsen, Helmut Sparrer

Arthritis Rheum· December 2009

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Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis.
Laszlo Revesz, Birgit Bollbuck, Thomas Buhl, Joerg Eder, Ronald Esser, Helmut Sparrer

Bioorg Med Chem Lett· December 2005

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