Publications by authors named "Martin Geiser"

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Seamless Insert-Plasmid Assembly at High Efficiency and Low Cost.
Roger M Benoit, Christian Ostermeier, Martin Geiser, Julia Su Zhou Li, Hans Widmer

PLoS One· August 2016

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NMR-Based Strategies to Elucidate Bioactive Conformations of Weakly Binding Ligands.
Marcel J J Blommers, Andre Strauss, Martin Geiser, Paul Ramage, Helmut Sparrer

Top Curr Chem· April 2013

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Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery.
Wolfgang Jahnke, Jean-Michel Rondeau, Simona Cotesta, Andreas Marzinzik, Xavier Pellé, Martin Geiser

Nat Chem Biol· September 2010

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Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.
Jürgen Wagner, Peter von Matt, Richard Sedrani, Rainer Albert, Nigel Cooke, Martin Geiser

J Med Chem· October 2009

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Chaperone over-expression in Escherichia coli: apparent increased yields of soluble recombinant protein kinases are due mainly to soluble aggregates.
Annette Haacke, Gabriele Fendrich, Paul Ramage, Martin Geiser

Protein Expr Purif· April 2009

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Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes.
Joerg Kallen, Arnaud Goepfert, Anke Blechschmidt, Aude Izaac, Martin Geiser

J Biol Chem· March 2009

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Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism.
Joerg Kallen, Rene Lattmann, Rene Beerli, Anke Blechschmidt, Marcel J J Blommers, Martin Geiser

J Biol Chem· August 2007

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Rapid and easy thermodynamic optimization of the 5'-end of mRNA dramatically increases the level of wild type protein expression in Escherichia coli.
Régis Cèbe, Martin Geiser

Protein Expr Purif· February 2006

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Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs.
Jean-Michel Rondeau, Francis Bitsch, Emmanuelle Bourgier, Martin Geiser, Rene Hemmig

ChemMedChem· February 2006

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Selective estrogen receptor modulators with conformationally restricted side chains. Synthesis and structure-activity relationship of ERalpha-selective tetrahydroisoquinoline ligands.
Johanne Renaud, Serge François Bischoff, Thomas Buhl, Philipp Floersheim, Brigitte Fournier, Martin Geiser

J Med Chem· January 2005

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Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha.
Joerg Kallen, Jean-Marc Schlaeppi, Francis Bitsch, Ireos Filipuzzi, Alain Schilb, Martin Geiser

J Biol Chem· November 2004

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X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha.
Joerg A Kallen, Jean-Marc Schlaeppi, Francis Bitsch, Sabine Geisse, Martin Geiser

Structure· December 2002

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