Publications by authors named "Rainer Albert"

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Structure-activity relationship and pharmacokinetic studies of sotrastaurin (AEB071), a promising novel medicine for prevention of graft rejection and treatment of psoriasis.
Jürgen Wagner, Peter von Matt, Bernard Faller, Nigel G Cooke, Rainer Albert

J Med Chem· September 2011

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Pyrazole derived from (+)-3-carene; a novel potent, selective scaffold for sphingosine-1-phosphate (S1P(1)) receptor agonists.
Frédéric J Zécri, Rainer Albert, Gregory Landrum, Klaus Hinterding, Nigel G Cooke

Bioorg Med Chem Lett· January 2010

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Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.
Jürgen Wagner, Peter von Matt, Richard Sedrani, Rainer Albert, Nigel Cooke

J Med Chem· October 2009

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The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity.
Elzbieta Sawicka, Gerald Dubois, Gabor Jarai, Matthew Edwards, Matthew Thomas, Rainer Albert

J Immunol· December 2005

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Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer.
Rainer Albert, Klaus Hinterding, Volker Brinkmann, Danilo Guerini, Constanze Müller-Hartwieg

J Med Chem· August 2005

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FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance.
Hiroshi Yasui, Teru Hideshima, Noopur Raje, Aldo M Roccaro, Norihiko Shiraishi, Rainer Albert

Cancer Res· August 2005

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1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1.
Sompong Wattanasin, Joerg Kallen, Stewart Myers, Qin Guo, Michael Sabio, Rainer Albert

Bioorg Med Chem Lett· February 2005

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Orally bioavailable competitive CCR5 antagonists.
Gebhard Thoma, François Nuninger, Marc Schaefer, Kayhan G Akyel, Rainer Albert

J Med Chem· April 2004

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Opportunities in somatostatin research: biological, chemical and therapeutic aspects.
Gisbert Weckbecker, Ian Lewis, Rainer Albert, Herbert A Schmid, Daniel Hoyer

Nat Rev Drug Discov· December 2003

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A novel somatostatin mimic with broad somatotropin release inhibitory factor receptor binding and superior therapeutic potential.
Ian Lewis, Wilfried Bauer, Rainer Albert, Nagarajan Chandramouli, Janos Pless

J Med Chem· June 2003

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1,4-Diazepane-2-ones as novel inhibitors of LFA-1.
Sompong Wattanasin, Rainer Albert, Claus Ehrhardt, Didier Roche, Michael Sabio

Bioorg Med Chem Lett· February 2003

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The immune modulator FTY720 targets sphingosine 1-phosphate receptors.
Volker Brinkmann, Michael D Davis, Christopher E Heise, Rainer Albert, Sylvain Cottens

J Biol Chem· June 2002

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