Publications by authors named "Danilo Guerini"

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ADA2 is a lysosomal deoxyadenosine deaminase acting on DNA involved in regulating TLR9-mediated immune sensing of DNA.
Ole Kristian Greiner-Tollersrud, Máté Krausz, Vincent Boehler, Aikaterini Polyzou, Maximilian Seidl, Danilo Guerini

Cell Rep· November 2024

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Small molecule induced STING degradation facilitated by the HECT ligase HERC4.
Merve Mutlu, Isabel Schmidt, Andrew I Morrison, Benedikt Goretzki, Felix Freuler, Danilo Guerini

Nat Commun· May 2024

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STING Agonists/Antagonists: Their Potential as Therapeutics and Future Developments.
Danilo Guerini

Cells· March 2022

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STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia.
Giulio Morozzi, Julian Rothen, Gauthier Toussaint, Katrina De Lange, Katrin Westritschnig, Danilo Guerini

iScience· December 2021

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TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis.
Joschka Willemsen, Marie-Therese Neuhoff, Thomas Hoyler, Emma Noir, Clemence Tessier, Danilo Guerini

Cell Rep· November 2021

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Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors.
Juraj Velcicky, Casey J N Mathison, Victor Nikulin, Daniel Pflieger, Robert Epple, Danilo Guerini

ACS Med Chem Lett· June 2019

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Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo.
Juraj Velcicky, Ursula Bodendorf, Pascal Rigollier, Robert Epple, Daniel R Beisner, Danilo Guerini

J Med Chem· February 2018

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Effective "activated PI3Kδ syndrome"-targeted therapy with the PI3Kδ inhibitor leniolisib.
V Koneti Rao, Sharon Webster, Virgil A S H Dalm, Anna Šedivá, P Martin van Hagen, Danilo Guerini

Blood· November 2017

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Identification of SPPL2a Inhibitors by Multiparametric Analysis of a High-Content Ultra-High-Throughput Screen.
Xian Zhang, Marjo Götte, Yvonne Ibig-Rehm, Ansgar Schuffenhauer, Marion Kamke, Danilo Guerini

SLAS Discov· October 2017

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Investigating the molecular mechanisms through which FTY720-P causes persistent S1P1 receptor internalization.
David A Sykes, Darren M Riddy, Craig Stamp, Michelle E Bradley, Neil McGuiness, Danilo Guerini

Br J Pharmacol· November 2014

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Second generation S1P pathway modulators: research strategies and clinical developments.
Marc Bigaud, Danilo Guerini, Andreas Billich, Frederic Bassilana, Volker Brinkmann

Biochim Biophys Acta· May 2014

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A potent and selective S1P(1) antagonist with efficacy in experimental autoimmune encephalomyelitis.
Jean Quancard, Birgit Bollbuck, Philipp Janser, Daniela Angst, Frédéric Berst, Danilo Guerini

Chem Biol· September 2012

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Oxysterols direct immune cell migration via EBI2.
Sébastien Hannedouche, Juan Zhang, Tangsheng Yi, Weijun Shen, Deborah Nguyen, Danilo Guerini

Nature· July 2011

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Design and synthesis of selective and potent orally active S1P5 agonists.
Henri Mattes, Kumlesh Kumar Dev, Rochdi Bouhelal, Carmen Barske, Fabrizio Gasparini, Danilo Guerini

ChemMedChem· October 2010

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Pyrazole derived from (+)-3-carene; a novel potent, selective scaffold for sphingosine-1-phosphate (S1P(1)) receptor agonists.
Frédéric J Zécri, Rainer Albert, Gregory Landrum, Klaus Hinterding, Nigel G Cooke, Danilo Guerini

Bioorg Med Chem Lett· January 2010

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Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors.
Florian Mullershausen, Frédéric Zecri, Cihan Cetin, Andreas Billich, Danilo Guerini

Nat Chem Biol· June 2009

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Reversible translocation of p115-RhoGEF by G(12/13)-coupled receptors.
Bruno H Meyer, Felix Freuler, Danilo Guerini, Sandra Siehler

J Cell Biochem· August 2008

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The O-linked N-acetylglucosamine modification in cellular signalling and the immune system. 'Protein modifications: beyond the usual suspects' review series.
Alexander Golks, Danilo Guerini

EMBO Rep· August 2008

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Synthesis and immobilization of erythro-C14-omega-aminosphingosine-1-phosphate as a potential tool for affinity chromatography.
Thomas Ullrich, Michael Ghobrial, Carsten Peters, Andreas Billich, Danilo Guerini

ChemMedChem· February 2008

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Requirement for O-linked N-acetylglucosaminyltransferase in lymphocytes activation.
Alexander Golks, Thi-Thanh Thao Tran, Jean Francois Goetschy, Danilo Guerini

EMBO J· October 2007

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Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors.
Florian Mullershausen, Luis M Craveiro, Youngah Shin, Marta Cortes-Cros, Frederic Bassilana, Danilo Guerini

J Neurochem· August 2007

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Novel GPCR screening approach: indirect identification of S1P receptor agonists in antagonist screening using a calcium assay.
Sandra Siehler, Danilo Guerini

J Recept Signal Transduct Res· March 2007

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Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors.
Stephen Hanessian, Guillaume Charron, Andreas Billich, Danilo Guerini

Bioorg Med Chem Lett· January 2007

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A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model.
Shifeng Pan, Yuan Mi, Charles Pally, Christian Beerli, Alice Chen, Danilo Guerini

Chem Biol· November 2006

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NBD-labeled derivatives of the immunomodulatory drug FTY720 as tools for metabolism and mode of action studies.
Peter Ettmayer, Thomas Baumruker, Danilo Guerini, Diana Mechtcheriakova, Peter Nussbaumer

Bioorg Med Chem Lett· January 2006

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