Publications by authors named "Peter Nussbaumer"

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TRPC5 controls the adrenaline-mediated counter regulation of hypoglycemia.
Jenny Bröker-Lai, José Rego Terol, Christin Richter, Ilka Mathar, Angela Wirth, Peter Nussbaumer

EMBO J· December 2024

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Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors.
Jonas Lategahn, Hannah L Tumbrink, Carsten Schultz-Fademrecht, Alena Heimsoeth, Lisa Werr, Peter Nussbaumer

J Med Chem· May 2022

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IMI European Lead Factory - democratizing access to high-throughput screening.
Philip S Jones, Sylviane Boucharens, Stuart P McElroy, Angus Morrison, Saman Honarnejad, Peter Nussbaumer

Nat Rev Drug Discov· April 2022

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Small-molecule inhibitors of human mitochondrial DNA transcription.
Nina A Bonekamp, Bradley Peter, Hauke S Hillen, Andrea Felser, Tim Bergbrede, Peter Nussbaumer

Nature· December 2020

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Chemical Validation of DegS As a Target for the Development of Antibiotics with a Novel Mode of Action.
Jens Bongard, Anna Laura Schmitz, Alex Wolf, Gunther Zischinsky, Michel Pieren, Peter Nussbaumer

ChemMedChem· June 2019

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Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo.
Lydia Reinhardt, Susanne Kordes, Peter Reinhardt, Michael Glatza, Matthias Baumann, Peter Nussbaumer

Stem Cell Reports· March 2019

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Gasdermin D plays a vital role in the generation of neutrophil extracellular traps.
Gabriel Sollberger, Axel Choidas, Garth Lawrence Burn, Peter Habenberger, Raffaella Di Lucrezia, Peter Nussbaumer

Sci Immunol· August 2018

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TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.
Sin Ying Cheung, Matthias Henrot, Mohammad Al-Saad, Matthias Baumann, Heiko Muller, Peter Nussbaumer

Oncotarget· July 2018

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Interaction of KRas4B protein with C6-ceramide containing lipid model membranes.
Lei Li, Mridula Dwivedi, Nelli Erwin, Simone Möbitz, Peter Nussbaumer

Biochim Biophys Acta Biomembr· May 2018

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Identification of Noncatalytic Lysine Residues from Allosteric Circuits via Covalent Probes.
Jens Bongard, Marian Lorenz, Ingrid R Vetter, Patricia Stege, Arthur T Porfetye, Peter Nussbaumer

ACS Chem Biol· May 2018

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Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein.
Susanne Höing, Ting-Yu Yeh, Matthias Baumann, Nancy E Martinez, Peter Habenberger, Peter Nussbaumer

Cell Chem Biol· April 2018

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Identification of an (-)-englerin A analogue, which antagonizes (-)-englerin A at TRPC1/4/5 channels.
Hussein N Rubaiy, Tobias Seitz, Sven Hahn, Axel Choidas, Peter Habenberger, Peter Nussbaumer

Br J Pharmacol· March 2018

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Na entry through heteromeric TRPC4/C1 channels mediates (-)Englerin A-induced cytotoxicity in synovial sarcoma cells.
Katsuhiko Muraki, Kaori Ohnishi, Akiho Takezawa, Hiroka Suzuki, Noriyuki Hatano, Peter Nussbaumer

Sci Rep· December 2017

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Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer.
Ulrich Lücking, Arne Scholz, Philip Lienau, Gerhard Siemeister, Dirk Kosemund, Peter Nussbaumer

ChemMedChem· November 2017

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Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening.
Eline Sijbesma, Lukasz Skora, Seppe Leysen, Luc Brunsveld, Uwe Koch, Peter Nussbaumer

Biochemistry· August 2017

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Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site.
Sandip Murarka, Pablo Martín-Gago, Carsten Schultz-Fademrecht, Alaa Al Saabi, Matthias Baumann, Peter Nussbaumer

Chemistry· May 2017

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Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels.
Hussein N Rubaiy, Melanie J Ludlow, Matthias Henrot, Hannah J Gaunt, Katarina Miteva, Peter Nussbaumer

J Biol Chem· May 2017

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Professional translational research: a new hybrid paradigm in early drug discovery.
Peter Nussbaumer, Bert Klebl

Future Med Chem· July 2016

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The Evolving Role of the Medicinal Chemist.
Geoff Lawton, Peter Nussbaumer

Prog Med Chem· April 2016

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Identification of pyrazolopyridazinones as PDEδ inhibitors.
Björn Papke, Sandip Murarka, Holger A Vogel, Pablo Martín-Gago, Marija Kovacevic, Peter Nussbaumer

Nat Commun· April 2016

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Medicinal Chemists of the 21(st) Century--Who Are We and Where to Go?
Peter Nussbaumer

ChemMedChem· July 2015

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Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents.
Romeo Romagnoli, Pier Giovanni Baraldi, Carlota Lopez-Cara, Maria Kimatrai Salvador, Delia Preti, Peter Nussbaumer

Bioorg Med Chem· September 2014

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Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site.
Gunther Zimmermann, Carsten Schultz-Fademrecht, Philipp Küchler, Sandip Murarka, Shehab Ismail, Peter Nussbaumer

J Med Chem· June 2014

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Cheminformatics at the interface of medicinal chemistry and proteomics.
Uwe Koch, Michael Hamacher, Peter Nussbaumer

Biochim Biophys Acta· January 2014

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S1P receptor mediated activity of FTY720 phosphate mimics.
Klemens Högenauer, Klaus Hinterding, Peter Nussbaumer

Bioorg Med Chem Lett· March 2010

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