Publications by authors named "Nigel Cooke"

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Structure-Based and Property-Driven Optimization of -Aryl Imidazoles toward Potent and Selective Oral RORγt Inhibitors.
Klemens Hoegenauer, Joerg Kallen, Eloísa Jiménez-Núñez, Ross Strang, Peter Ertl, Nigel G Cooke

J Med Chem· December 2019

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Optimizing a Weakly Binding Fragment into a Potent RORγt Inverse Agonist with Efficacy in an in Vivo Inflammation Model.
David A Carcache, Anna Vulpetti, Joerg Kallen, Henri Mattes, David Orain, Nigel G Cooke

J Med Chem· August 2018

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Investigating the Structure-Activity Relationship of the Insecticidal Natural Product Rocaglamide.
Roger G Hall, Ian Bruce, Nigel G Cooke, Louis J Diorazio, Fredrik Cederbaum

Chimia (Aarau)· December 2017

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Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors.
Klemens Hoegenauer, Nicolas Soldermann, Frédéric Zécri, Ross S Strang, Nadege Graveleau, Nigel G Cooke

ACS Med Chem Lett· September 2017

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Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator.
Shifeng Pan, Nathanael S Gray, Wenqi Gao, Yuan Mi, Yi Fan, Nigel G Cooke

ACS Med Chem Lett· March 2013

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Structure-activity relationship and pharmacokinetic studies of sotrastaurin (AEB071), a promising novel medicine for prevention of graft rejection and treatment of psoriasis.
Jürgen Wagner, Peter von Matt, Bernard Faller, Nigel G Cooke, Rainer Albert

J Med Chem· September 2011

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Pyrazole derived from (+)-3-carene; a novel potent, selective scaffold for sphingosine-1-phosphate (S1P(1)) receptor agonists.
Frédéric J Zécri, Rainer Albert, Gregory Landrum, Klaus Hinterding, Nigel G Cooke

Bioorg Med Chem Lett· January 2010

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Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.
Jürgen Wagner, Peter von Matt, Richard Sedrani, Rainer Albert, Nigel Cooke

J Med Chem· October 2009

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Reduced cardiac side-effect potential by introduction of polar groups: discovery of NIBR-1282, an orally bioavailable CCR5 antagonist which is active in vivo.
Gebhard Thoma, Christian Beerli, Marc Bigaud, Christian Bruns, Nigel G Cooke

Bioorg Med Chem Lett· March 2008

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A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model.
Shifeng Pan, Yuan Mi, Charles Pally, Christian Beerli, Alice Chen, Nigel Cooke

Chem Biol· November 2006

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Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer.
Rainer Albert, Klaus Hinterding, Volker Brinkmann, Danilo Guerini, Constanze Müller-Hartwieg, Nigel Cooke

J Med Chem· August 2005

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A rapidly increasing pleural effusion.
Timothy B L Ho, Philip Alexander, Nigel T Cooke

J R Soc Med· January 2004

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