Publications by authors named "Henry Scott"

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Redox regulation of neuroinflammatory pathways contributes to damage in Alzheimer's disease brain.
Lauren N Carnevale, Piu Banerjee, Xu Zhang, Jazmin Navarro, Charlene K Raspur, Henry Scott

bioRxiv· September 2025

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The Coach's Eye: A Randomized Repeated-Measure Observational Study Assessing Coaches' Perception of Velocity Loss During Resistance Training Exercises.
Antonio Dello Iacono, Scott Henry, Asaf Ben-Ari, Israel Halperin, Laura Carey

Sports Med Open· July 2025

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Antisense oligonucleotide jacifusen for FUS-ALS: an investigator-initiated, multicentre, open-label case series.
Neil A Shneider, Matthew B Harms, Vlad A Korobeynikov, Olivia M Rifai, Benjamin N Hoover, Scott Henry

Lancet· June 2025

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Cellular immune changes during severe antisense oligonucleotide-associated thrombocytopenia in a nonhuman primate model.
Sheena Gupta, Lijiang Shen, Scott P Henry, Nima Aghaeepour, Padmakumar Narayanan

J Immunol· April 2025

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Inhibiting the alternative pathway of complement by reducing systemic complement factor B: Randomized, double-blind, placebo-controlled phase 1 studies with Sefaxersen.
Michael L McCaleb, Steven G Hughes, Tamar R Grossman, Ashley Frazer-Abel, Bill Jung, Scott P Henry

Immunobiology· March 2025

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S-Nitrosylation of CRTC1 in Alzheimer's disease impairs CREB-dependent gene expression induced by neuronal activity.
Xu Zhang, Roman Vlkolinsky, Chongyang Wu, Nima Dolatabadi, Henry Scott

Proc Natl Acad Sci U S A· March 2025

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Assessing Hybridization-Dependent Off-Target Risk for Therapeutic Oligonucleotides: Updated Industry Recommendations.
Patrik Andersson, Sebastien A Burel, Heather Estrella, Jeffrey Foy, Peter H Hagedorn, Scott P Henry

Nucleic Acid Ther· February 2025

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Carcinogenicity assessment of inotersen in Tg.rasH2 mice and Sprague-Dawley rats: Implications for 2'-MOE antisense oligonucleotides.
Tae-Won Kim, Chris N Papagiannis, Laura S Zwick, Paul Snyder, Jeffery A Engelhardt, Scott P Henry

Regul Toxicol Pharmacol· January 2025

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A Combined Fertility and Developmental Toxicity Study with an Antisense Oligonucleotide Targeting Murine Apolipoprotein C-III mRNA in Mice.
Ji-Seong Jeong, Archit Rastogi, Tae-Won Kim, Scott Henry, Christine M Hoffmaster

Nucleic Acid Ther· December 2024

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CpG oligonucleotides induce acute murine thrombocytopenia dependent on toll-like receptor 9 and spleen tyrosine kinase pathways.
Karl Johansson, Amal Maouia, Johan Rebetz, Geneviève Marcoux, Oonagh Shannon, Scott Henry

J Thromb Haemost· November 2024

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Single-Cell Patch-Clamp/Proteomics of Human Alzheimer's Disease iPSC-Derived Excitatory Neurons Versus Isogenic Wild-Type Controls Suggests Novel Causation and Therapeutic Targets.
Swagata Ghatak, Jolene K Diedrich, Maria Talantova, Nivedita Bhadra, Henry Scott

Adv Sci (Weinh)· August 2024

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S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons.
Paschalis-Thomas Doulias, Hongmei Yang, Alexander Y Andreyev, Nima Dolatabadi, Henry Scott

Cell Chem Biol· August 2023

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Complement C3d/C4d Deposition on Platelets Correlates with 2'-O-Methoxyethyl Antisense Oligonucleotide-Induced Thrombocytopenia in Monkeys.
Lijiang Shen, Andrea Wong, Satoru Oneda, Brian R Curtis, Joe Schroeder, Scott P Henry

Nucleic Acid Ther· June 2023

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Correlations between preclinical BJAB assay ranking of antisense drugs and clinical trial adverse events.
Wesley Partridge, Sebastien A Burel, Annie Ferng, Shuting Xia, T Jesse Kwoh, Scott P Henry

Clin Transl Sci· April 2023

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Assessment of the Effect of Organ Impairment on the Pharmacokinetics of 2'-MOE and Phosphorothioate Modified Antisense Oligonucleotides.
Yanfeng Wang, John K Diep, Rosie Z Yu, Eunju Hurh, Ewa Karwatowska-Prokopczuk, Scott Henry

J Clin Pharmacol· January 2023

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Population pharmacokinetic/pharmacodynamic modelling of eplontersen, an antisense oligonucleotide in development for transthyretin amyloidosis.
John K Diep, Rosie Z Yu, Nicholas J Viney, Eugene Schneider, Shuling Guo, Scott Henry

Br J Clin Pharmacol· December 2022

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Early-Stage Identification and Avoidance of Antisense Oligonucleotides Causing Species-Specific Inflammatory Responses in Human Volunteer Peripheral Blood Mononuclear Cells.
Sebastien A Burel, Todd Machemer, Brenda F Baker, T Jesse Kwoh, Suzanne Paz, Scott P Henry

Nucleic Acid Ther· December 2022

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Inflammatory Non-CpG Antisense Oligonucleotides Are Signaling Through TLR9 in Human Burkitt Lymphoma B Bjab Cells.
Adam J Pollak, Patrick Cauntay, Todd Machemer, Suzanne Paz, Sagar Damle, Scott P Henry

Nucleic Acid Ther· December 2022

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Assessment of the Immunogenicity Potential for Oligonucleotide-Based Drugs.
Scott P Henry, Cecilia Arfvidsson, Josh Arrington, Jasna Canadi, Dave Crowe

Nucleic Acid Ther· October 2022

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Sequence-specific 2'-O-methoxyethyl antisense oligonucleotides activate human platelets through glycoprotein VI, triggering formation of platelet-leukocyte aggregates.
Martina H Lundberg Slingsby, Prakrith Vijey, I-Ting Tsai, Harvey Roweth, Genevieve Couldwell, Scott P Henry

Haematologica· February 2022

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Antisense Oligonucleotide-Related Macrovesicular Vacuolation of Hippocampal Neurons in Nonhuman Primates.
Martin Lamb, Jeffery A Engelhardt, Branka Grubor, William A Meier, Tom F Magee, Scott P Henry

Toxicol Pathol· February 2022

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Interspecies Scaling of Human Clearance and Plasma Trough Exposure for Antisense Oligonucleotides: A Retrospective Analysis of GalNAc3-Conjugated and Unconjugated-Antisense Oligonucleotides.
Charvi Nanavati, Gina McMullen, Rosie Yu, Richard S Geary, Scott P Henry

Nucleic Acid Ther· August 2021

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TCA cycle metabolic compromise due to an aberrant S-nitrosoproteome in HIV-associated neurocognitive disorder with methamphetamine use.
Paschalis-Thomas Doulias, Tomohiro Nakamura, Henry Scott, Scott R McKercher, Abdullah Sultan

J Neurovirol· June 2021

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Correction to: TCA cycle metabolic compromise due to an aberrant S‑nitrosoproteome in HIV‑associated neurocognitive disorder with methamphetamine use.
Paschalis-Thomas Doulias, Tomohiro Nakamura, Henry Scott, Scott R McKercher, Abdullah Sultan

J Neurovirol· June 2021

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S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD.
Elaine Pirie, Chang-Ki Oh, Xu Zhang, Xuemei Han, Piotr Cieplak, Henry R Scott

Proc Natl Acad Sci U S A· March 2021

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