Publications by authors named "Jay Knipe"

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P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor.
Brian L Venables, Ny Sin, Alan Xiangdong Wang, Li-Qiang Sun, Yong Tu, Jay Knipe

Bioorg Med Chem Lett· June 2018

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Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor.
Barbara Zheng, Stanley V D'Andrea, Li-Qiang Sun, Alan Xiangdong Wang, Yan Chen, Jay O Knipe

ACS Med Chem Lett· February 2018

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The discovery and optimization of naphthalene-linked P2-P4 Macrocycles as inhibitors of HCV NS3 protease.
Michael Bowsher, Sheldon Hiebert, Rongti Li, Alan X Wang, Jacques Friborg, Jay O Knipe

Bioorg Med Chem Lett· January 2018

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Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase.
Barbara Zhizhen Zheng, Stanley V D'Andrea, Umesh Hanumegowda, Jay O Knipe, Kathy Mosure

Bioorg Med Chem Lett· August 2017

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Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies.
Kap-Sun Yeung, Brett R Beno, Kyle Parcella, John A Bender, Katherine A Grant-Young, Jay O Knipe

J Med Chem· May 2017

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Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus.
Alan Xiangdong Wang, Jie Chen, Qian Zhao, Li-Qiang Sun, Jacques Friborg, Jay O Knipe

Bioorg Med Chem Lett· February 2017

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Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing.
Li-Qiang Sun, Eric Mull, Barbara Zheng, Stanley D'Andrea, Qian Zhao, Jay O Knipe

J Med Chem· September 2016

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Discovery and preclinical evaluation of potent, orally bioavailable, metabolically stable cyclopropylindolobenzazepine acylsulfonamides as thumb site 1 inhibitors of the hepatitis c virus NS5B RNA-dependent, RNA polymerase.
Piyasena Hewawasam, Yong Tu, Min Gao, Umesh Hanumegowda, Jay Knipe

Bioorg Med Chem Lett· February 2016

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Preclinical Pharmacokinetics and In Vitro Metabolism of Asunaprevir (BMS-650032), a Potent Hepatitis C Virus NS3 Protease Inhibitor.
Kathleen W Mosure, Jay O Knipe, Marc Browning, Vinod Arora, Yue-Zhong Shu

J Pharm Sci· September 2015

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Preclinical pharmacokinetics and in vitro metabolism of BMS-605339: a novel HCV NS3 protease inhibitor.
Susan Jenkins, Paul Scola, Fiona McPhee, Jay Knipe, Christoph Gesenberg

J Pharm Sci· June 2014

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Preclinical characterization of BMS-791325, an allosteric inhibitor of hepatitis C Virus NS5B polymerase.
Julie A Lemm, Mengping Liu, Robert G Gentles, Min Ding, Stacey Voss, Jay O Knipe

Antimicrob Agents Chemother· June 2014

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Identification of a novel series of potent HCV NS5B Site I inhibitors.
Kyle J Eastman, Zhong Yang, John A Bender, Kathy Mosure, Julie A Lemm, Jay Knipe

Bioorg Med Chem Lett· April 2014

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Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase.
Robert G Gentles, Min Ding, John A Bender, Carl P Bergstrom, Katharine Grant-Young, Jay Knipe

J Med Chem· March 2014

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Hepatitis C virus NS5A replication complex inhibitors. Part 6: Discovery of a novel and highly potent biarylimidazole chemotype with inhibitory activity toward genotypes 1a and 1b replicons.
Makonen Belema, Van N Nguyen, Jeffrey L Romine, Denis R St Laurent, Omar D Lopez, Jay O Knipe

J Med Chem· March 2014

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Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir.
Makonen Belema, Van N Nguyen, Carol Bachand, Dan H Deon, Jason T Goodrich, Jay O Knipe

J Med Chem· March 2014

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Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.
Paul M Scola, Alan Xiangdong Wang, Andrew C Good, Li-Qiang Sun, Keith D Combrink, Jay O Knipe

J Med Chem· March 2014

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The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection.
Paul M Scola, Li-Qiang Sun, Alan Xiangdong Wang, Jie Chen, Ny Sin, Jay O Knipe

J Med Chem· March 2014

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HCV NS5A replication complex inhibitors. Part 5: discovery of potent and pan-genotypic glycinamide cap derivatives.
Makonen Belema, Van N Nguyen, Denis R St Laurent, Omar D Lopez, Yuping Qiu, Jay O Knipe

Bioorg Med Chem Lett· August 2013

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Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032).
Fiona McPhee, Amy K Sheaffer, Jacques Friborg, Dennis Hernandez, Paul Falk, Jay Knipe

Antimicrob Agents Chemother· October 2012

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HCV NS5A replication complex inhibitors. Part 2: investigation of stilbene prolinamides.
Denis R St Laurent, Makonen Belema, Min Gao, Jason Goodrich, Ramesh Kakarla, Jay O Knipe

Bioorg Med Chem Lett· October 2012

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Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: potent allosteric inhibitors of the hepatitis C virus NS5B polymerase.
Min Ding, Feng He, Thomas W Hudyma, Xiaofan Zheng, Michael A Poss, Jay Knipe

Bioorg Med Chem Lett· April 2012

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Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.
Xiaofan Zheng, Thomas W Hudyma, Scott W Martin, Carl Bergstrom, Min Ding, Jay Knipe

Bioorg Med Chem Lett· May 2011

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Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect.
Min Gao, Richard E Nettles, Makonen Belema, Lawrence B Snyder, Van N Nguyen, Jay O Knipe

Nature· May 2010

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Nonclinical pharmacokinetics of BMS-292655, a water-soluble prodrug of the antifungal ravuconazole.
Jay O Knipe, Kathleen W Mosure

Biopharm Drug Dispos· July 2008

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An automated liquid chromatography-mass spectrometry process to determine metabolic stability half-life and intrinsic clearance of drug candidates by substrate depletion.
Colleen A McNaney, Dieter M Drexler, Serhiy Y Hnatyshyn, Tatyana A Zvyaga, Jay O Knipe

Assay Drug Dev Technol· February 2008

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