Publications by authors named "Paul Scola"

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Cu-Catalyzed Amination of Base-Sensitive Aryl Bromides and the Chemoselective N- and O-Arylation of Amino Alcohols.
Michael J Strauss, Kaylee X Liu, Megan E Greaves, Jakob C Dahl, Seoung-Tae Kim, Paul M Scola

J Am Chem Soc· July 2024

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Room-Temperature Copper-Catalyzed Etherification of Aryl Bromides.
Michael J Strauss, Megan E Greaves, Seoung-Tae Kim, Christiana N Teijaro, Michael A Schmidt, Paul M Scola

Angew Chem Int Ed Engl· May 2024

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Challenges with the Synthesis of a Macrocyclic Thioether Peptide: From Milligram to Multigram Using Solid Phase Peptide Synthesis (SPPS).
James Kempson, Rulin Zhao, Joseph Pawluczyk, Bei Wang, Huiping Zhang, Paul M Scola

J Org Chem· May 2024

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Development, Characterization, and Radiation Dosimetry Studies of F-BMS-986229, a F-Labeled PD-L1 Macrocyclic Peptide PET Tracer.
Joonyoung Kim, David J Donnelly, Tritin Tran, Adrienne Pena, Andrea Olga Shorts, Paul M Scola

Mol Imaging Biol· April 2024

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The discovery and evaluation of [F]BMS-986229, a novel macrocyclic peptide PET radioligand for the measurement of PD-L1 expression and in-vivo PD-L1 target engagement.
David J Donnelly, Joonyoung Kim, Tritin Tran, Paul M Scola, Daniel Tenney

Eur J Nucl Med Mol Imaging· March 2024

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Deoxyfluorination of 1°, 2°, and 3° Alcohols by Nonbasic O-H Activation and Lewis Acid-Catalyzed Fluoride Shuttling.
Hye Won Moon, Marissa N Lavagnino, Soohyun Lim, Maximilian D Palkowitz, Michael D Mandler, Paul M Scola

J Am Chem Soc· October 2023

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Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection.
Li-Qiang Sun, Eric Mull, Stanley D'Andrea, Barbara Zheng, Sheldon Hiebert, Paul M Scola

J Med Chem· December 2020

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A General Amino Acid Synthesis Enabled by Innate Radical Cross-Coupling.
Shengyang Ni, Alberto F Garrido-Castro, Rohan R Merchant, Justine N de Gruyter, Daniel C Schmitt, Paul M Scola

Angew Chem Int Ed Engl· October 2018

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P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor.
Brian L Venables, Ny Sin, Alan Xiangdong Wang, Li-Qiang Sun, Yong Tu, Paul M Scola

Bioorg Med Chem Lett· June 2018

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Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor.
Barbara Zheng, Stanley V D'Andrea, Li-Qiang Sun, Alan Xiangdong Wang, Yan Chen, Paul M Scola

ACS Med Chem Lett· February 2018

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The discovery and optimization of naphthalene-linked P2-P4 Macrocycles as inhibitors of HCV NS3 protease.
Michael Bowsher, Sheldon Hiebert, Rongti Li, Alan X Wang, Jacques Friborg, Paul M Scola

Bioorg Med Chem Lett· January 2018

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Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products.
Lara R Malins, Justine N deGruyter, Kevin J Robbins, Paul M Scola, Martin D Eastgate

J Am Chem Soc· April 2017

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Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus.
Alan Xiangdong Wang, Jie Chen, Qian Zhao, Li-Qiang Sun, Jacques Friborg, Paul M Scola

Bioorg Med Chem Lett· February 2017

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Functionalized triazines as potent HCV entry inhibitors.
Eric S Mull, Li-Qiang Sun, Qian Zhao, Betsy Eggers, Kevin Pokornowski, Paul M Scola

Bioorg Med Chem Lett· February 2017

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Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing.
Li-Qiang Sun, Eric Mull, Barbara Zheng, Stanley D'Andrea, Qian Zhao, Paul M Scola

J Med Chem· September 2016

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Preclinical Pharmacokinetics and In Vitro Metabolism of Asunaprevir (BMS-650032), a Potent Hepatitis C Virus NS3 Protease Inhibitor.
Kathleen W Mosure, Jay O Knipe, Marc Browning, Vinod Arora, Yue-Zhong Shu, Paul Scola

J Pharm Sci· September 2015

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Ligand-enabled β-C-H arylation of α-amino acids using a simple and practical auxiliary.
Gang Chen, Toshihiko Shigenari, Pankaj Jain, Zhipeng Zhang, Zhong Jin, Paul M Scola

J Am Chem Soc· March 2015

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Preclinical pharmacokinetics and in vitro metabolism of BMS-605339: a novel HCV NS3 protease inhibitor.
Susan Jenkins, Paul Scola, Fiona McPhee, Jay Knipe, Christoph Gesenberg

J Pharm Sci· June 2014

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Structure activity relationship studies of 3-arylsulfonyl-pyrido[1,2-a]pyrimidin-4-imines as potent 5-HT₆ antagonists.
Shuanghua Hu, Yazhong Huang, Yong-Jin Wu, Huan He, Katherine A Grant-Young, Paul M Scola

Bioorg Med Chem· March 2014

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Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.
Paul M Scola, Alan Xiangdong Wang, Andrew C Good, Li-Qiang Sun, Keith D Combrink

J Med Chem· March 2014

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The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection.
Paul M Scola, Li-Qiang Sun, Alan Xiangdong Wang, Jie Chen, Ny Sin

J Med Chem· March 2014

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Establishment of a robust hepatitis C virus replicon cell line over-expressing P-glycoprotein that facilitates analysis of P-gp drug transporter effects on inhibitor antiviral activity.
Dennis Hernandez, Paul Falk, Fei Yu, Guangzhi Zhai, Yong Quan, Paul Scola

Biochem Pharmacol· January 2013

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Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032).
Fiona McPhee, Amy K Sheaffer, Jacques Friborg, Dennis Hernandez, Paul Falk, Paul Scola

Antimicrob Agents Chemother· October 2012

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Single- and multiple-ascending-dose studies of the NS3 protease inhibitor asunaprevir in subjects with or without chronic hepatitis C.
Claudio Pasquinelli, Fiona McPhee, Timothy Eley, Criselda Villegas, Katrina Sandy, Paul Scola

Antimicrob Agents Chemother· April 2012

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Developments in antiviral drug design, discovery and development in 2004.
Nicholas A Meanwell, Makonen Belema, David J Carini, Stanley V D'Andrea, John F Kadow, Paul M Scola

Curr Drug Targets Infect Disord· December 2005

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