Publications by authors named "Jean-Pascal Herault"

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Molecular Mechanism of SSR128129E, an Extracellularly Acting, Small-Molecule, Allosteric Inhibitor of FGF Receptor Signaling.
Corentin Herbert, Ulrich Schieborr, Krishna Saxena, Jarek Juraszek, Frederik De Smet, Jean-Pascal Herault

Cancer Cell· July 2016

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Investigation of the selectivity of thrombin-binding aptamers for thrombin titration in murine plasma.
Ana Trapaidze, Jean-Pascal Hérault, Jean-Marc Herbert, Aurélien Bancaud, Anne-Marie Gué

Biosens Bioelectron· April 2016

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Targeted identification of sialoglycoproteins in hypoxic endothelial cells and validation in zebrafish reveal roles for proteins in angiogenesis.
Nicolas Delcourt, Celia Quevedo, Christelle Nonne, Pierre Fons, Donogh O'Brien

J Biol Chem· February 2015

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Tumor vasculature is regulated by FGF/FGFR signaling-mediated angiogenesis and bone marrow-derived cell recruitment: this mechanism is inhibited by SSR128129E, the first allosteric antagonist of FGFRs.
Pierre Fons, Geneviève Gueguen-Dorbes, Jean-Pascal Herault, Fabien Geronimi, Joël Tuyaret

J Cell Physiol· January 2015

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N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist.
Christophe Boldron, Angélina Besse, Marie-Françoise Bordes, Stéphanie Tissandié, Xavier Yvon

J Med Chem· September 2014

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Specific Inhibition of the VEGFR-3 Tyrosine Kinase by SAR131675 Reduces Peripheral and Tumor Associated Immunosuppressive Myeloid Cells.
Nicolas Espagnolle, Pauline Barron, Marie Mandron, Isabelle Blanc, Jacques Bonnin, Jean Pascal Herault

Cancers (Basel)· February 2014

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5-Chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide (SAR107375), a selective and potent orally active dual thrombin and factor Xa inhibitor.
Jerome Meneyrol, Markus Follmann, Gilbert Lassalle, Volkmar Wehner, Guillaume Barre, Jean-Pascal Herault

J Med Chem· December 2013

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Automated image analysis of in vitro angiogenesis assay.
Marie-Laure Boizeau, Pierre Fons, Lionel Cousseins, Josette Desjobert, David Sibrac

J Lab Autom· October 2013

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Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties.
Françoise Bono, Frederik De Smet, Corentin Herbert, Katrien De Bock, Maria Georgiadou, Jean-Pascal Herault

Cancer Cell· April 2013

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Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling.
Corentin Herbert, Ulrich Schieborr, Krishna Saxena, Jarek Juraszek, Frederik De Smet, Jean-Pascal Herault

Cancer Cell· April 2013

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SAR131675, a potent and selective VEGFR-3-TK inhibitor with antilymphangiogenic, antitumoral, and antimetastatic activities.
Antoine Alam, Isabelle Blanc, Geneviève Gueguen-Dorbes, Olivier Duclos, Jacques Bonnin

Mol Cancer Ther· August 2012

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Soluble HLA-G and control of angiogenesis.
Philippe Le Bouteiller, Pierre Fons, Jean-Pascal Herault, Françoise Bono, Sophie Chabot

J Reprod Immunol· December 2007

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Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells.
Pierre Fons, Sophie Chabot, Judith E Cartwright, Francoise Lenfant, Fatima L'Faqihi, Jean-Pascal Herault

Blood· October 2006

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Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration.
Benoit Favier, Antoine Alam, Pauline Barron, Jacques Bonnin, Patricia Laboudie, Jean-Pascal Herault

Blood· August 2006

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Effect of fondaparinux on platelet activation in the presence of heparin-dependent antibodies: a blinded comparative multicenter study with unfractionated heparin.
Pierre Savi, Beng H Chong, Andreas Greinacher, Yves Gruel, John G Kelton, Jean-Pascal Herault

Blood· January 2005

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Heterodimerization with vascular endothelial growth factor receptor-2 (VEGFR-2) is necessary for VEGFR-3 activity.
Antoine Alam, Jean-Pascal Herault, Pauline Barron, Benoit Favier, Pierre Fons

Biochem Biophys Res Commun· November 2004

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Accelerating ability of synthetic oligosaccharides on antithrombin inhibition of proteinases of the clotting and fibrinolytic systems. Comparison with heparin and low-molecular-weight heparin.
Steven T Olson, Richard Swanson, Elke Raub-Segall, Tina Bedsted, Morvardi Sadri

Thromb Haemost· November 2004

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VEGF-R2 and neuropilin-1 are involved in VEGF-A-induced differentiation of human bone marrow progenitor cells.
Pierre Fons, Jean-Pascal Herault, Nathalie Delesque, Joēl Tuyaret, Françoise Bono

J Cell Physiol· September 2004

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Effects of SanOrg123781A, a synthetic hexadecasaccharide, in a mouse model of electrically induced carotid artery injury: synergism with the antiplatelet agent clopidogrel.
Janine Lorrain, Irène Lechaire, Christiane Gauffeny, Régis Masson, Nigel Roome, Jean-Pascal Herault

J Pharmacol Exp Ther· April 2004

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SSR182289A, a selective and potent orally active thrombin inhibitor.
Jean-Michel Altenburger, Gilbert Y Lassalle, Mostapha Matrougui, Daniel Galtier, Jean-Claude Jetha, Jean-Pascal Herault

Bioorg Med Chem· April 2004

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Life-threatening thrombosis in mice with targeted Arg48-to-Cys mutation of the heparin-binding domain of antithrombin.
Mieke Dewerchin, Jean-Pascal Hérault, Goedele Wallays, Maurice Petitou, Paul Schaeffer

Circ Res· November 2003

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SSR182289A, a novel, orally active thrombin inhibitor: in vitro profile and ex vivo anticoagulant activity.
Christopher N Berry, Gilbert Lassalle, Catherine Lunven, Jean-Michel Altenburger, Frédérique Guilbert

J Pharmacol Exp Ther· December 2002

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Synthesis of Conformationally Locked Carbohydrates: A Skew-Boat Conformation of L-Iduronic Acid Governs the Antithrombotic Activity of Heparin.
Sanjoy K. Das, Jean-Maurice Mallet, Jacques Esnault, Pierre-Alexandre Driguez, Philippe Duchaussoy

Angew Chem Int Ed Engl· May 2001

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