Publications by authors named "Jeremy Caldwell"

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NHE3 inhibitor tenapanor maintains intestinal barrier function, decreases visceral hypersensitivity, and attenuates TRPV1 signaling in colonic sensory neurons.
Andrew J King, Lin Chang, Qian Li, Liansheng Liu, Yaohui Zhu, Jeremy S Caldwell

Am J Physiol Gastrointest Liver Physiol· May 2024

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Modeling the Kinetics of Lipid-Nanoparticle- Mediated Delivery of Multiple siRNAs to Evaluate the Effect on Competition for Ago2.
Radu Mihaila, Dipali Ruhela, Beverly Galinski, Ananda Card, Mark Cancilla, Jeremy Caldwell

Mol Ther Nucleic Acids· June 2019

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Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice.
Patricia D Finn, David Rodriguez, Jill Kohler, Zhengfeng Jiang, Sindy Wan, Jeremy S Caldwell

Am J Physiol Gastrointest Liver Physiol· March 2019

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Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5).
Tao Chen, Nicholas William Reich, Noah Bell, Patricia D Finn, David Rodriguez, Jeremy S Caldwell

J Med Chem· September 2018

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Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability.
Andrew J King, Matthew Siegel, Ying He, Baoming Nie, Ji Wang, Jeremy S Caldwell

Sci Transl Med· August 2018

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Evaluation of the Pharmacodynamic Effects of the Potassium Binder RDX7675 in Mice.
James P Davidson, Andrew J King, Padmapriya Kumaraswamy, Jeremy S Caldwell, Paul Korner

J Cardiovasc Pharmacol Ther· May 2018

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Development and Characterization of a Human and Mouse Intestinal Epithelial Cell Monolayer Platform.
Kenji Kozuka, Ying He, Samantha Koo-McCoy, Padmapriya Kumaraswamy, Baoming Nie, Jeremy S Caldwell

Stem Cell Reports· December 2017

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Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing.
Samnang Tep, Radu Mihaila, Alexander Freeman, Victoria Pickering, Felicia Huynh, Jeremy Caldwell

J Lipid Res· May 2012

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Parsimonious discovery of synergistic drug combinations.
Bryan Severyn, Robert A Liehr, Alex Wolicki, Kevin H Nguyen, Edward M Hudak, Jeremy S Caldwell

ACS Chem Biol· December 2011

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HTS-Compatible Patient-Derived Cell-Based Assay to Identify Small Molecule Modulators of Aberrant Splicing in Myotonic Dystrophy Type 1.
Debra A O'Leary, Leonardo Vargas, Orzala Sharif, Michael E Garcia, Yury J Sigal, Jeremy S Caldwell

Curr Chem Genomics· March 2010

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Identification and characterization of a small molecule antagonist of human VPAC(2) receptor.
Alan Chu, Jeremy S Caldwell, Yu Alice Chen

Mol Pharmacol· January 2010

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Identification of small molecule and genetic modulators of AON-induced dystrophin exon skipping by high-throughput screening.
Debra A O'Leary, Orzala Sharif, Paul Anderson, Buu Tu, Genevieve Welch, Jeremy S Caldwell

PLoS One· December 2009

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Time-resolved fluorescence resonance energy transfer and surface plasmon resonance-based assays for retinoid and transthyretin binding to retinol-binding protein 4.
Orzala Sharif, Huiyong Hu, Heath Klock, Eric N Hampton, Edward Nigoghossian, Jeremy S Caldwell

Anal Biochem· September 2009

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Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients.
Kan V Lu, Shaojun Zhu, Anna Cvrljevic, Tiffany T Huang, Shawn Sarkaria, Jeremy S Caldwell

Cancer Res· September 2009

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A time-resolved fluorescence resonance energy transfer-based assay for DEN1 peptidase activity.
Ingo H Engels, Catherine Daguia, Truc Huynh, Hugo Urbina, Jörg Buddenkotte, Jeremy S Caldwell

Anal Biochem· July 2009

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Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay.
Hong Yin, Alan Chu, Wei Li, Bin Wang, Fabiola Shelton, Jeremy S Caldwell

J Biol Chem· May 2009

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An intracellular conformational sensor assay for Abl T315I.
Vicki Zhou, Xiaoqi Gao, Shulin Han, Achim Brinker, Jeremy S Caldwell

Anal Biochem· February 2009

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Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.
Renate König, Yingyao Zhou, Daniel Elleder, Tracy L Diamond, Ghislain M C Bonamy, Jeremy S Caldwell

Cell· October 2008

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In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy.
Susan E Cellitti, David H Jones, Leanna Lagpacan, Xueshi Hao, Qiong Zhang, Jeremy Caldwell

J Am Chem Soc· July 2008

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In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.
David Plouffe, Achim Brinker, Case McNamara, Kerstin Henson, Nobutaka Kato, Jeremy S Caldwell

Proc Natl Acad Sci U S A· July 2008

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An interview with Jeremy S. Caldwell.
Jeremy S Caldwell

Assay Drug Dev Technol· June 2008

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Cellular Ser/Thr-kinase assays using generic peptide substrates.
Deanna G Adams, Yu Wang, Puiying A Mak, Jason Chyba, Orzala Shalizi, Jeremy S Caldwell

Curr Chem Genomics· May 2008

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Whole genome functional analysis identifies novel components required for mitotic spindle integrity in human cells.
Daniel R Rines, Maria Ana Gomez-Ferreria, Yingyao Zhou, Paul DeJesus, Seanna Grob, Jeremy S Caldwell

Genome Biol· May 2008

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Human Cep192 is required for mitotic centrosome and spindle assembly.
Maria Ana Gomez-Ferreria, Uttama Rath, Daniel W Buster, Sumit K Chanda, Jeremy S Caldwell

Curr Biol· November 2007

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Cellular homeoproteins, SATB1 and CDP, bind to the unique region between the human cytomegalovirus UL127 and major immediate-early genes.
Jialing Lee, Zachary Klase, Xiaoqi Gao, Jeremy S Caldwell, Mark F Stinski

Virology· September 2007

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