Publications by authors named "Jessica Orf"

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Discovery of Bis-Acyl Hydrazides as Potent and Bioavailable MTA-Cooperative PRMT5 Inhibitors: A Case Study of Leveraging the Deuterium Kinetic Isotope Effect.
Laurent Debien, Megan K Armstrong, Joshua D Farr, Ryan D Ferrao, Pancham Lal Gupta, Jessica Orf

J Med Chem· December 2025

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Brief report: STING expressed in tumor and non-tumor compartments has distinct roles in regulating anti-tumor immunity.
Jennie C Kim, Xian Liu, Karen Fitzgerald, Jason S Eng, Jessica Orf

Cancer Immunol Immunother· May 2023

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Activity of tumor-associated macrophage depletion by CSF1R blockade is highly dependent on the tumor model and timing of treatment.
Sarah A O'Brien, Jessica Orf, Katarzyna M Skrzypczynska, Hong Tan, Jennie Kim

Cancer Immunol Immunother· August 2021

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Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer.
Lei Zhang, Ziyi Li, Katarzyna M Skrzypczynska, Qiao Fang, Wei Zhang, Jessica Orf

Cell· April 2020

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Generation of bone marrow chimeras using X-ray irradiation: comparison to cesium irradiation and use in immunotherapy.
Jason Eng, Jessica Orf, Kristy Perez, Deepali Sawant, Jason DeVoss

J Biol Methods· February 2020

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Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia.
Kathleen Keegan, Cong Li, Zhihong Li, Ji Ma, Mark Ragains, Jessica Orf

Mol Cancer Ther· April 2014

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The optimization of aminooxadiazoles as orally active inhibitors of Cdc7.
Paul E Harrington, Matthew P Bourbeau, Christopher Fotsch, Michael Frohn, Alexander J Pickrell, Jessica N Orf

Bioorg Med Chem Lett· December 2013

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Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth.
F Michael Yakes, Jason Chen, Jenny Tan, Kyoko Yamaguchi, Yongchang Shi, Jessica Orf

Mol Cancer Ther· December 2011

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Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hit.
Matthew L Brown, Wade Aaron, Richard J Austin, Angela Chong, Tom Huang, Jessica Orf

Bioorg Med Chem Lett· September 2011

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Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines.
Jacob A Kaizerman, Wade Aaron, Songzhu An, Richard Austin, Matt Brown, Jessica Orf

Bioorg Med Chem Lett· August 2010

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Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists.
Brian S Lucas, Wade Aaron, Songzhu An, Richard J Austin, Matthew Brown, Jessica Orf

Bioorg Med Chem Lett· June 2010

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Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1.
Edward Htun van der Horst, Yan Y Degenhardt, Astrid Strelow, Anthony Slavin, Lawrence Chinn, Jessica Orf

Proc Natl Acad Sci U S A· November 2005

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